Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Marion Pepper"'
Autor:
Samuel D. Klebanoff, Lauren B. Rodda, Chihiro Morishima, Mark H. Wener, Yevgeniy Yuzefpolskiy, Estelle Bettelli, Jane H. Buckner, Cate Speake, Marion Pepper, Daniel J. Campbell
Publikováno v:
JCI Insight, Vol 8, Iss 15 (2023)
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that causes debilitating swelling and destruction of the joints. People with RA are treated with drugs that actively suppress one or more parts of their immune system, and these
Externí odkaz:
https://doaj.org/article/13459b7a9d15424893fed20f19913b0c
Publikováno v:
eLife, Vol 12 (2023)
Naturally acquired immunity to malaria develops only after many years and repeated exposures, raising the question of whether Plasmodium parasites, the etiological agents of malaria, suppress the ability of dendritic cells (DCs) to activate optimal T
Externí odkaz:
https://doaj.org/article/a92d2ce29a0542af95f9cbcbe2c352b6
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 594-606 (2020)
Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear. Interferon lambda (IFNλ), a type III interferon, is a cytokin
Externí odkaz:
https://doaj.org/article/e84b43c0af7148f3803c226d2380e90a
Autor:
Linhui Hao, Tien-Ying Hsiang, Ronit R. Dalmat, Renee Ireton, Jennifer F. Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M. Franko, Kristen Huden, Helen Y. Chu, Alex Sigal, Alex L. Greninger, Sasha Tilles, Lynn K. Barrett, Wesley C. Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S. Baric, David J. Rawlings, Marion Pepper, Paul K. Drain, Michael Gale
Publikováno v:
Viruses, Vol 15, Iss 2, p 530 (2023)
New variants of SARS-CoV-2 continue to emerge and evade immunity. We isolated SARS-CoV-2 temporally across the pandemic starting with the first emergence of the virus in the western hemisphere and evaluated the immune escape among variants. A clinic-
Externí odkaz:
https://doaj.org/article/fdaa1f3636174da08d27e757b88a435b
Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein
Autor:
Gladys J. Keitany, Karen S. Kim, Akshay T. Krishnamurty, Brian D. Hondowicz, William O. Hahn, Nicholas Dambrauskas, D. Noah Sather, Ashley M. Vaughan, Stefan H.I. Kappe, Marion Pepper
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3193-3205 (2016)
Many current malaria vaccines target the pre-erythrocytic stage of infection in the liver. However, in malaria-endemic regions, increased blood stage exposure is associated with decreased vaccine efficacy, thereby challenging current vaccine efforts.
Externí odkaz:
https://doaj.org/article/c696799bd66349bbb1b8efcefd3d4b73
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1446-1460.e4 (2019)
Summary: FCRL5+ atypical memory B cells (atMBCs) expand in many chronic human infections, including recurrent malaria, but studies have drawn opposing conclusions about their function. Here, in mice infected with Plasmodium chabaudi, we demonstrate e
Externí odkaz:
https://doaj.org/article/6a990d71b05c440b8b9653dc6d636b3f
Autor:
Julia Merkenschlager, Mickaël J. Ploquin, Urszula Eksmond, Rakieb Andargachew, Georgina Thorborn, Andrew Filby, Marion Pepper, Brian Evavold, George Kassiotis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
During an immune response, CD4+ T cell repertoire is thought to increase in avidity at the expense of diversity. Here the authors show that B cells act as antigen-presenting cells to boost the development of low-avidity T cell clones, diversifying th
Externí odkaz:
https://doaj.org/article/25bffa91449947648b99e2c787621c0f
Autor:
Christopher D Dupont, David A Christian, Elizabeth M Selleck, Marion Pepper, Michael Leney-Greene, Gretchen Harms Pritchard, Anita A Koshy, Sagie Wagage, Morgan A Reuter, L David Sibley, Michael R Betts, Christopher A Hunter
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004047 (2014)
During infection with the intracellular parasite Toxoplasma gondii, the presentation of parasite-derived antigens to CD4+ and CD8+ T cells is essential for long-term resistance to this pathogen. Fundamental questions remain regarding the roles of pha
Externí odkaz:
https://doaj.org/article/2977843c3cf144dca58b9f44dc6e611a
Autor:
Thamotharampillai Dileepan, Jonathan L Linehan, James J Moon, Marion Pepper, Marc K Jenkins, Patrick P Cleary
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002252 (2011)
Group A streptococcus (GAS, Streptococcus pyogenes) is the cause of a variety of clinical conditions, ranging from pharyngitis to autoimmune disease. Peptide-major histocompatibility complex class II (pMHCII) tetramers have recently emerged as a high
Externí odkaz:
https://doaj.org/article/d814d7e28b4942138c32dea9b1a9f51e
Autor:
Jolie M. Phan, Erik D. Layton, Krystle K. Q. Yu, Melissa S. Aguilar, Inah Golez, Nicholas M. Franko, Jennifer K. Logue, Lauren B. Rodda, Christian A. Howard, Marion Pepper, Michael Gale, Helen Y. Chu, Chetan Seshadri
Publikováno v:
The Journal of Immunology. 210:1236-1246
mRNA vaccination of individuals with prior SARS-CoV-2 infection provides superior protection against breakthrough infections with variants of concern compared with vaccination in the absence of prior infection. However, the immune mechanisms by which