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Autor:
Marion Pepper
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 41(10)
Autor:
Samuel D. Klebanoff, Lauren B. Rodda, Chihiro Morishima, Mark H. Wener, Yevgeniy Yuzefpolskiy, Estelle Bettelli, Jane H. Buckner, Cate Speake, Marion Pepper, Daniel J. Campbell
Publikováno v:
JCI Insight, Vol 8, Iss 15 (2023)
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that causes debilitating swelling and destruction of the joints. People with RA are treated with drugs that actively suppress one or more parts of their immune system, and these
Externí odkaz:
https://doaj.org/article/13459b7a9d15424893fed20f19913b0c
Publikováno v:
eLife, Vol 12 (2023)
Naturally acquired immunity to malaria develops only after many years and repeated exposures, raising the question of whether Plasmodium parasites, the etiological agents of malaria, suppress the ability of dendritic cells (DCs) to activate optimal T
Externí odkaz:
https://doaj.org/article/a92d2ce29a0542af95f9cbcbe2c352b6
Autor:
Linhui Hao, Tien-Ying Hsiang, Ronit R. Dalmat, Renee Ireton, Jennifer F. Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M. Franko, Kristen Huden, Helen Y. Chu, Alex Sigal, Alex L. Greninger, Sasha Tilles, Lynn K. Barrett, Wesley C. Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S. Baric, David J. Rawlings, Marion Pepper, Paul K. Drain, Michael Gale
Publikováno v:
Viruses, Vol 15, Iss 2, p 530 (2023)
New variants of SARS-CoV-2 continue to emerge and evade immunity. We isolated SARS-CoV-2 temporally across the pandemic starting with the first emergence of the virus in the western hemisphere and evaluated the immune escape among variants. A clinic-
Externí odkaz:
https://doaj.org/article/fdaa1f3636174da08d27e757b88a435b
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 594-606 (2020)
Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear. Interferon lambda (IFNλ), a type III interferon, is a cytokin
Externí odkaz:
https://doaj.org/article/e84b43c0af7148f3803c226d2380e90a
Autor:
Jolie M. Phan, Erik D. Layton, Krystle K. Q. Yu, Melissa S. Aguilar, Inah Golez, Nicholas M. Franko, Jennifer K. Logue, Lauren B. Rodda, Christian A. Howard, Marion Pepper, Michael Gale, Helen Y. Chu, Chetan Seshadri
Publikováno v:
The Journal of Immunology. 210:1236-1246
mRNA vaccination of individuals with prior SARS-CoV-2 infection provides superior protection against breakthrough infections with variants of concern compared with vaccination in the absence of prior infection. However, the immune mechanisms by which
Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein
Autor:
Gladys J. Keitany, Karen S. Kim, Akshay T. Krishnamurty, Brian D. Hondowicz, William O. Hahn, Nicholas Dambrauskas, D. Noah Sather, Ashley M. Vaughan, Stefan H.I. Kappe, Marion Pepper
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3193-3205 (2016)
Many current malaria vaccines target the pre-erythrocytic stage of infection in the liver. However, in malaria-endemic regions, increased blood stage exposure is associated with decreased vaccine efficacy, thereby challenging current vaccine efforts.
Externí odkaz:
https://doaj.org/article/c696799bd66349bbb1b8efcefd3d4b73
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1446-1460.e4 (2019)
Summary: FCRL5+ atypical memory B cells (atMBCs) expand in many chronic human infections, including recurrent malaria, but studies have drawn opposing conclusions about their function. Here, in mice infected with Plasmodium chabaudi, we demonstrate e
Externí odkaz:
https://doaj.org/article/6a990d71b05c440b8b9653dc6d636b3f