Interferon α kinoid induces neutralizing anti-interferon α antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon α kinoid phase I/II study

Autor: Bernard Lauwerys, Géraldine Grouard-Vogel, Fabien Colaone, François Spertini, Christian Jorgensen, Thérèse Croughs, Estibaliz Lazaro, Julie Ducreux, Camille Roucairol, Frédéric Houssiau, Pierre Vandepapelière, Marion Laborie

Publikováno v: Rheumatology
Rheumatology, Oxford University Press (OUP), 2016, 55 (10), pp.1901-1905. ⟨10.1093/rheumatology/kew262⟩
Rheumatology (Oxford, England)
Rheumatology (Oxford, England), vol. 55, no. 10, pp. 1901-1905

Objective. IFN α Kinoid (IFN-K) is a therapeutic vaccine composed of IFNα2b coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the IFN gene signature in whole blood RNA samples fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f43119e18d0192b98d39fa25d2543d7
https://hal.archives-ouvertes.fr/hal-01864876

Modulation of anti-tumor necrosis factor alpha (TNF-α) antibody secretion in mice immunized with TNF-α kinoid

Autor: Géraldine Grouard-Vogel, Natacha Bessis, Marion Laborie, Laure Delavallée, Eric Assier, Emilie Bernier, Marie-Christophe Boissier, Emilie Duvallet, Patrick Larcier, Luca Semerano

Publikováno v: Clinical and vaccine immunology : CVI. 19(5)

Tumor necrosis factor alpha (TNF-α) blockade is an effective treatment for patients with TNF-α-dependent chronic inflammatory diseases, such as rheumatoid arthritis, Crohn's disease, and psoriasis. TNF-α kinoid, a heterocomplex of human TNF-α and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db30c03b08b228f13be68be96d1c92c6
https://pubmed.ncbi.nlm.nih.gov/22441388