Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Marion L. Drozd"'
Autor:
Suzanne C. Aldous, Frank J. Dutko, Dorff Peter H, Marion L. Drozd, Mark P. Wentland, Robert B. Perni, Maureen G. Woods, John A. Carlson, Susan D. Kingsley, Kathryn A. Ryan, Dorothy C. Young, David Rosi
Publikováno v:
Journal of Medicinal Chemistry. 38:2541-2545
Supported by the antiherpetic properties of 3-quinolinecarboxamides and the importance of the planar intramolecular H-bonded beta-keto amide pharmacophore, a series of novel conformationally rigid analogues that contain a heterocyclic bridge between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ae71c9d3bc3761d3549fb9fcd8a7ed
https://doi.org/10.1021/jm00014a006
https://doi.org/10.1021/jm00014a006
Autor:
Robert J. Gordan, Chakrapani Subramanyam, W. Mark Eickhoff, Marion L. Drozd, David T. Robinson, Edward D. Pagani, Judith A. Johnson, Dennis J. Hlasta, Catherine A. Franke, Ranjit Ch Desai, Paul J. Silver, Alan L. Maycock, John F. Newton, Edward W. Ferguson, Dunlap Richard Paul, Eugene R. Baizman
Publikováno v:
Drug Development Research. 34:306-316
The proteolytic activity of human neutrophil elastase (HNE) has been implicated in a number of pulmonary diseases. We report on the activity of an orally bioavailable, selective HNE inhibitor, WIN 63759 [6-methoxy-4-(1-methylethy)-3-oxo-1,2-benzisoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b219826e23c3c6d5355f8c72f702212f
https://doi.org/10.1002/ddr.430340308
https://doi.org/10.1002/ddr.430340308
Autor:
Marion L. Drozd, Denise M. Reilly, D DeMaria, Martin A. Graham, Joseph D. Purvis, James P. Stevenson, Graham F. Lockwood, Peter J. O'Dwyer
Publikováno v:
Cancer chemotherapy and pharmacology. 44(3)
Purpose: SR233377 (WIN33377) is a novel 4-aminomethyl thioxanthone derivative with promising preclinical activity against solid tumors at doses substantially below the MTD. We performed a phase I trial to determine a suitable phase II dose of SR23337
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20c9bbd0c31f045db2d391a747e7611
https://pubmed.ncbi.nlm.nih.gov/10453724
https://pubmed.ncbi.nlm.nih.gov/10453724
Publikováno v:
Journal of chromatography. B, Biomedical applications. 670(1)
WIN 33377 (I) is a member of a novel class of cytotoxic antitumor agents, 4-aminomethyl thioxanthone derivatives. A simple, rapid and reproducible method has been developed for the assay of I in mouse plasma using a high-performance liquid chromatogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8265ecb7026e7437a8a5a3881f3e7bbb
https://pubmed.ncbi.nlm.nih.gov/7493072
https://pubmed.ncbi.nlm.nih.gov/7493072
Autor:
Sandhya Subramanian, Virendra Kumar, Catherine A. Franke, Dunlap Richard Paul, Dennis J. Hlasta, Malcolm R. Bell, Edward Ferguson, Anne G. Rowlands, Judith A. Johnson, John J. Court, David Robinson, Manohar Saindane, Marion L. Drozd, Chakrapani Subramanyam, Alan L. Maycock, Karl R. Mueller, W. Mark Eickhoff, Paul J. Silver, Albert J. Mura, Edward D. Pagani, Robert J. Gordon, Ranjit C. Desai, Philip M. Carabateas
Publikováno v:
Journal of medicinal chemistry. 38(5)
Human leukocyte elastase (HLE) has been proposed as a primary mediator of pulmonary emphysema and other inflammatory airway diseases. HLE is capable of cleaving many proteins, including elastin, other components of connective tissue, certain compleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd72bd054d626ee601414321d310026
https://pubmed.ncbi.nlm.nih.gov/7877139
https://pubmed.ncbi.nlm.nih.gov/7877139
Publikováno v:
The Journal of antibiotics. 34(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033b2a72e8715e8941a4780567f1dea5
https://pubmed.ncbi.nlm.nih.gov/7275813
https://pubmed.ncbi.nlm.nih.gov/7275813