Výsledky vyhledávání - "Marion Klaumünzer"

Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series

Autor: Andreas D. Hartkopf, Florian Battke, Eva-Maria Grischke, Sara Y. Brucker, Marion Klaumünzer, André Koch, Saskia Biskup, Martin Schulze, Florin-Andrei Taran, Christina B. Walter

Publikováno v: Oncotarget

Purpose High throughput panel sequencing to tailor therapy in precision oncology promises to improve outcome in patients with metastatic breast cancer. However, data that clearly show any benefit from such an approach is still pending. Materials and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a148cbd927feae3d3cf34b2f1ba908
http://europepmc.org/articles/PMC7476733

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Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy

Publikováno v: Blood. 128:395-404

Genetic instability is a feature of chronic lymphocytic leukemia (CLL) with adverse prognosis. We hypothesized that chromosomal translocations or complex karyotypes and distinct somatic mutations may impact outcome after first-line chemoimmunotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86f2acea2f1ce9ee0d62f9c9aa14fba1
https://doi.org/10.1182/blood-2016-01-691550

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A Novel Protective Function for Cytokinin in the Light Stress Response Is Mediated by the ARABIDOPSIS HISTIDINE KINASE2 and ARABIDOPSIS HISTIDINE KINASE3 Receptors

Autor: Thomas Schmülling, Silvia Nitschke, Marion Klaumünzer, Han Asard, Michael Riefler, Anne Cortleven, Hamada AbdElgawad, Bernhard Grimm

Publikováno v: Plant physiology

Cytokinins are plant hormones that regulate diverse processes in plant development and responses to biotic and abiotic stresses. In this study, we show that Arabidopsis (Arabidopsis thaliana) plants with a reduced cytokinin status (i.e. cytokinin rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d53680d6c9e3158ab9c8159ed002e92
https://doi.org/10.1104/pp.113.224667

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Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance

Autor: Norihiko Kawamata, Maximilian Mossner, Seishi Ogawa, Rachael A. Papa, Motohiro Kato, Nils H. Thoennissen, Masashi Sanada, Daniel Nowak, Ryoko Okamoto, H. Phillip Koeffler, Marion Klaumünzer, Tadayuki Akagi, Richard B. Lock, Johann Christoph Jann, Glenn M. Marshall, Verena Nowak, Natalia L. M. Liem, Wolf-Karsten Hofmann

Publikováno v: Experimental hematology. 43(1)

The use of genome-wide copy-number analysis and massive parallel sequencing has revolutionized the understanding of the clonal architecture of pediatric acute lymphoblastic leukemia (ALL) by demonstrating that this disease is composed of highly varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd736021cb1483384606d0d332ab254
https://pubmed.ncbi.nlm.nih.gov/25450514

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Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assay

Autor: Claudia D. Baldus, Gero Hütter, Uwe Neumann, Julia Obländer, Henning Röhl, Florian Nolte, S. Will, Wolf-Karsten Hofmann, Verena Nowak, Martin Neumann, Jana Reins, Olaf Hopfer, Maximilian Mossner, Katrin Ackermann, Marion Klaumünzer, Daniel Nowak

Publikováno v: Journal of medical genetics. 50(2)

Background Investigation of X-chromosome inactivation patterns (XCIP) by determination of differential CpG-methylation has been widely applied for investigation of female cell clonality. Using this approach the clonal origin of various tumours has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674330fbfa6ccdc461697206b860cfc5
https://pubmed.ncbi.nlm.nih.gov/23339109

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Detection of Highly Clonal CD34+, Mononuclear Bone Marrow and Peripheral Blood Cells From Patients with Myelodysplastic Syndrome and Age Related Increase of Clonal Hematopoiesis In Healthy Subjects Using a Novel Transcriptional Pyrosequencing Based Clonality Assay

Autor: Katrin Ackermann, Olaf Hopfer, Maximilian Mossner, Julia Obländer, Wolf-Karsten Hofmann, Daniel Nowak, Verena Nowak, Claudia D. Baldus, Eckhard Thiel, Marion Klaumünzer, Susanne Brendel

Publikováno v: Blood. 116:977-977

Abstract 977 X-chromosome inactivation occurs in female cells leading to stochastically random silencing of one X-chromosome. Accordingly, investigation of X-chromosome inactivation patterns (XCIP) in healthy female tissues revealed similar ratios of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0b6fdb764e7e48628544f3aabd253dc
https://doi.org/10.1182/blood.v116.21.977.977

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The New CD95 Ligand Inhibitor APG101 Leads To Decreased Apoptosis and Improved Erythroid Differentiation In Primary CD34+Cells From Patients With Low Risk Myelodysplastic Syndrome (MDS)

Autor: Stefanie Uhlig, Wolf-Karsten Hofmann, Claudia Kunz, Florian Nolte, Maximilian Mossner, Susanne Brendel, Harald Fricke, Daniel Nowak, Marion Klaumünzer, Julia Obländer, Stephanie Fey, Johann-Christoph Jann

Publikováno v: ResearcherID

Introduction Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal myeloid malignancies characterized by ineffective hematopoiesis and an increased risk of transformation into acute myeloid leukemia. Particularly early stage MDS are at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed885c7e57bc0ac9c6bdc4c416ed60eb
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000331385003200&KeyUID=WOS:000331385003200

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