Expression of Alternatively Spliced Human T-Cell Leukemia Virus Type 1 mRNAs Is Influenced by Mitosis and by a Novel cis -Acting Regulatory Sequence

Autor: Vincenzo Ciminale, Joanna Sztuba-Solinska, Ilaria Cavallari, Genoveffa Franchini, Stuart F. J. LeGrice, Micol Silic-Benussi, Martina Tognon, Donna M. D'Agostino, Francesca Rende, Marion K. Bona

Publikováno v: Journal of Virology. 90:1486-1498

Human T-cell leukemia virus type 1 (HTLV-1) expression depends on the concerted action of Tax, which drives transcription of the viral genome, and Rex, which favors expression of incompletely spliced mRNAs and determines a 2-phase temporal pattern of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bba59290d31be084103d4bdc206fa00
https://doi.org/10.1128/jvi.02298-15

Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid

Autor: Marion K. Bona, Dmitri I. Svergun, Wojciech Potrzebowski, Stuart F.J. Le Grice, Marcin Nowotny, Elzbieta Nowak, Jason W. Rausch, Janusz M. Bujnicki, Petr V. Konarev

Publikováno v: 'Nucleic Acids Research ', vol: 41, pages: 3874-3887 (2013)
Nucleic Acids Research
Nucleic acids symposium series 41(6), 3874-3887 (2013). doi:10.1093/nar/gkt053
ICT FP7 Publications Database
ILL-ESRF publications
DESY Publication Database
OpenAIRE
Europe PubMed Central

A key step in proliferation of retroviruses is the conversion of their RNA genome to double-stranded DNA, a process catalysed by multifunctional reverse transcriptases (RTs). Dimeric and monomeric RTs have been described, the latter exemplified by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa57591dff05779f76df422204c6d0a
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:36290

Correlating SHAPE signatures with three-dimensional RNA structures

Autor: Yi Wang, Michaela Wendeler, Stuart F.J. Le Grice, Eckart Bindewald, Bruce A. Shapiro, Mark J. Pritt, Marion K. Bona, Michal Legiewicz

Publikováno v: RNA. 17:1688-1696

Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) is a facile technique for quantitative analysis of RNA secondary structure. In general, low SHAPE signal values indicate Watson-Crick base-pairing, and high values indicate positi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4bad7cdcdbe780a52cf4f059f06931
https://doi.org/10.1261/rna.2640111

Novel insights from structural analysis of lentiviral and gammaretroviral reverse transcriptases in complex with RNA/DNA hybrids

Autor: Wojciech Marek Potrzebowski, Jason W. Rausch, Janusz M. Bujnicki, Mikalai Lapkouski, Dmitri I. Svergun, Wei Yang, Marcin Nowotny, Lan Tian, Elzbieta Nowak, Stuart F.J. Le Grice, Jennifer T. Miller, Marion K. Bona, Peter V. Konarev

Publikováno v: Retrovirology

Structures of HIV-1 reverse transcriptase (RT) have been reported in several forms, but only one contains an RNA/DNA hybrid, the conformation of which has been controversial. We have been successful in obtaining three structures of HIV-1 RT complexed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7244ddeebe8ab44593475f4c59f4cd
https://doi.org/10.1186/1742-4690-10-s1-p46

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

Autor: Oleg Chertov, Hsiu-Fang Lee, Maryam Ehteshami, Mamuka Kvaratskhelia, John A. Beutler, Matthias Götte, Alun Bermingham, Jennifer T. Miller, Barry R. O'Keefe, Michaela Wendeler, Noel S. Baichoo, Stuart F. J. Le Grice, Marion K. Bona

Publikováno v: ACS chemical biology. 3(10)

High-throughput screening of National Cancer Institute libraries of synthetic and natural compounds identified the vinylogous ureas 2-amino-5,6,7,8-tetrahydro-4 H-cyclohepta[ b]thiophene-3-carboxamide (NSC727447) and N-[3-(aminocarbonyl)-4,5-dimethyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9d167256872482f6db3376be48dbc2
https://pubmed.ncbi.nlm.nih.gov/18831589