Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marion J. Perren"'
Autor:
Andrew D. Medhurst, Jennifer C. Roberts, John B. Davis, David Virley, Marion J. Perren, Sarah Friel, Shilina Roman, Jill C. Richardson, Alex J. Harper
Publikováno v:
Experimental Neurology. 216:459-470
Chronic inflammation is known to occur in the brains of Alzheimer's Disease (AD) patients, including the presence of activated microglia close to amyloid plaques. We utilised real time autoradiography and immunohistochemistry to investigate microglia
Autor:
Peter Jenner, Sarah Rose, Marion J. Perren, K. Stockwell, David Virley, Michael J. Jackson, Mahmoud M. Iravani
Publikováno v:
Experimental Neurology. 211:172-179
L-DOPA treatment of Parkinson's disease induces a high incidence of motor complications, notably dyskinesia. Longer acting dopamine agonists, e.g. ropinirole, are thought to produce more continuous dopaminergic stimulation and less severe dyskinesia.
Autor:
Neil Upton, Peter L. Woodhams, Helen Chapman, Martin P. Vidgeon-Hart, Marion J. Perren, Menelas N. Pangalos, Leann P. Quinn, David Virley, Kim Brackenborough
Publikováno v:
Journal of Neuroscience Methods. 164:43-49
A beam-walking apparatus has been evaluated for its ability to detect motor impairments in mice acutely treated with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg, s.c., single or double administration). Mic
Autor:
Tracey Ashmeade, David Virley, Andrew Billinton, Mark E. P. Hows, Angela A Austin, Ajit J. Shah, Marion J. Perren, Andrew J. Organ
Publikováno v:
Journal of Neuroscience Methods. 137:221-226
A high-throughput liquid chromatography/tandem mass spectrometry method has been developed for the quantitative assessment of 1-methyl-4-phenylpyridinium (MPP+) in brain tissue samples. This separation is based on reversed phase chromatography using
Autor:
Fabrizio Nerozzi, Shalia S Shabbir, Paul G. Wyatt, Mamta Patel, Michael Allen, Josie Chilcott, Christopher J. Gardner, Marion J. Perren, Jackie E. Mordaunt, Livermore David, Gordon G. Weingarten, Ping Zhou, Patrick M. Woollard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1405-1411
The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo
Autor:
Neil Upton, Simon T. Bate, Marion J. Perren, Flora Joyce, Jill C. Richardson, Tracey Ashmeade, Ainsley A. Culbert, David Virley, David Sunter, Zoe Seymour, Martin P. Vidgeon-Hart, Anna Babin, Perdita L. Pugh
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 4, Iss 1, p 8 (2007)
Journal of Neuroinflammation, Vol 4, Iss 1, p 8 (2007)
Background Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the m
Autor:
Marion J. Perren, Michael Allen, Patrick M. Woollard, Alan D. Borthwick, Paul G. Wyatt, Anne M. Exall, Dave E. Davies, Shalia S Shabbir, Steve L. Sollis, Fabrizio Nerozzi, Livermore David
Publikováno v:
Journal of medicinal chemistry. 48(22)
A short stereoselective synthesis of a series of chiral 7-aryl-2,5-diketopiperazines oxytocin antagonists is described. Varying the functionality and substitution pattern of substituents in the 7-aryl ring and varying the chirality of this exocyclic
Publikováno v:
Journal of neurology. 238
Migraine headache is thought to be associated with a dilatation of cranial blood vessels, particularly those in the dura mater, and an accompanying localized sterile inflammatory response. Sumatriptan is a highly selective 5-HT1-like receptor agonist
Publikováno v:
British journal of pharmacology. 102(1)
1. There is controversy about whether 5-HT1A receptors mediate contraction of isolated cerebral blood vessels. We have therefore compared the vascular actions of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propyl-amino)-tetralin (8-OH-DPAT) with t
Publikováno v:
Headache. 30