Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marion J J Gijbels"'
Autor:
Suzanne A B M Aarts, Myrthe E Reiche, Myrthe den Toom, Linda Beckers, Marion J J Gijbels, Norbert Gerdes, Menno P J de Winther, Esther Lutgens
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202150 (2018)
Obesity is a low-grade inflammatory disease that increases the risk for metabolic disorders. CD40-CD40L signaling plays a central role in obesity-induced inflammation. Genetic deficiency of CD40L in diet-induced obesity (DIO) ameliorates adipose tiss
Externí odkaz:
https://doaj.org/article/d814a689b6b64c32bf5208ea8e8a55b6
Autor:
Jieyi Li, Dipanjan Chanda, Patrick J van Gorp, Mike L J Jeurissen, Tom Houben, Sofie M A Walenbergh, Jacques Debets, Yvonne Oligschlaeger, Marion J J Gijbels, Dietbert Neumann, Ronit Shiri-Sverdlov
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163843 (2016)
Non-alcoholic steatohepatitis (NASH) is a common liver disease characterized by hepatic lipid accumulation (steatosis) and inflammation. Currently, therapeutic options are poor and the long-term burden to society is constantly increasing. Previously,
Externí odkaz:
https://doaj.org/article/13fd0e03ff88464486b21522e7e92df6
Autor:
Mike L J Jeurissen, Sofie M A Walenbergh, Tom Houben, Tim Hendrikx, Jieyi Li, Yvonne Oligschlaeger, Patrick J van Gorp, Marion J J Gijbels, Albert Bitorina, Isabell Nessel, Freddy Radtke, Marc Vooijs, Jan Theys, Ronit Shiri-Sverdlov
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167199 (2016)
Non-alcoholic steatohepatitis (NASH) is characterized by liver steatosis and inflammation. Currently, the underlying mechanisms leading to hepatic inflammation are not fully understood and consequently, therapeutic options are poor. Non-alcoholic ste
Externí odkaz:
https://doaj.org/article/a7d5cf775960487595bf8c82043d2d14
Autor:
Marcella van Leeuwen, Michael J Kemna, Menno P J de Winther, Louis Boon, Adriaan M Duijvestijn, Darius Henatsch, Nico A Bos, Marion J J Gijbels, Jan Willem Cohen Tervaert
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68039 (2013)
AIMS: New strategies to overcome complications of cardiovascular diseases are needed. Since it has been demonstrated that atherosclerosis is an inflammatory disease, modulation of the immune system may be a promising approach. Previously, it was sugg
Externí odkaz:
https://doaj.org/article/7c26904ce5e248e2bb3683821cc298ad
Autor:
Kristiaan Wouters, Céline Cudejko, Marion J J Gijbels, Lucia Fuentes, Kadiombo Bantubungi, Jonathan Vanhoutte, Rebecca Dièvart, Charlotte Paquet, Emmanuel Bouchaert, Sarah Anissa Hannou, Florence Gizard, Anne Tailleux, Menno P J de Winther, Bart Staels, Réjane Paumelle
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32440 (2012)
ObjectiveA genomic region near the CDKN2A locus, encoding p16(INK4a), has been associated to type 2 diabetes and atherosclerotic vascular disease, conditions in which inflammation plays an important role. Recently, we found that deficiency of p16(INK
Externí odkaz:
https://doaj.org/article/f1eb7ebaa8ee485b9bc67339bc01578d
Autor:
Marjo M P C Donners, Ine M J Wolfs, Lauran J Stöger, Emiel P C van der Vorst, Chantal C H Pöttgens, Stephane Heymans, Blanche Schroen, Marion J J Gijbels, Menno P J de Winther
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35877 (2012)
microRNA-155 (miR155) is a central regulator of immune responses that is induced by inflammatory mediators. Although miR155 is considered to be a pro-inflammatory microRNA, in vitro reports show anti-inflammatory effects in lipid-loaded cells. In thi
Externí odkaz:
https://doaj.org/article/d93298f3a1cc40cfb5f1b6dc30024435
Autor:
Veerle Bieghs, Fons Verheyen, Patrick J van Gorp, Tim Hendrikx, Kristiaan Wouters, Dieter Lütjohann, Marion J J Gijbels, Maria Febbraio, Christoph J Binder, Marten H Hofker, Ronit Shiri-Sverdlov
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34378 (2012)
Non-alcoholic steatohepatitis (NASH) is characterized by steatosis and inflammation, which can further progress into fibrosis and cirrhosis. Recently, we demonstrated that combined deletion of the two main scavenger receptors, CD36 and macrophage sca
Externí odkaz:
https://doaj.org/article/fc66fc6496794096b9edf4dc02b0e037
Autor:
Pieter Goossens, Monique N Vergouwe, Marion J J Gijbels, Danielle M J Curfs, Johannes H G van Woezik, Marten A Hoeksema, Sofia Xanthoulea, Pieter J M Leenen, Rudolf A Rupec, Marten H Hofker, Menno P J de Winther
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22327 (2011)
Activation of the transcription factor NF-κB appears to be involved in different stages of atherogenesis. In this paper we investigate the role of NF-κB inhibitor IκBα in atherosclerosis. Myeloid-specific deletion of IκBα results in larger and
Externí odkaz:
https://doaj.org/article/d7f278cd545e4fbe86342fcb62374d4a
Autor:
Saske Hoving, Sylvia Heeneman, Marion J J Gijbels, Johannes A M te Poele, Manlio Bolla, Jeffrey F C Pol, Michelle Y Simons, Nicola S Russell, Mat J Daemen, Fiona A Stewart
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12874 (2010)
BACKGROUND: We previously showed that irradiation to the carotid arteries of ApoE(-/-) mice accelerated the development of macrophage-rich, inflammatory atherosclerotic lesions, prone to intra-plaque hemorrhage. In this study we investigated the pote
Externí odkaz:
https://doaj.org/article/e8822741e0044f10a63b5ad47abd9469
Autor:
Marijn C Meuwese, Lysette N Broekhuizen, Mayella Kuikhoven, Sylvia Heeneman, Esther Lutgens, Marion J J Gijbels, Max Nieuwdorp, Carine J Peutz, Erik S G Stroes, Hans Vink, Bernard M van den Berg
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14262 (2010)
OBJECTIVE: Functional studies show that disruption of endothelial surface layer (ESL) is accompanied by enhanced sensitivity of the vasculature towards atherogenic stimuli. However, relevance of ESL disruption as causal mechanism for vascular dysfunc
Externí odkaz:
https://doaj.org/article/8db4529d025b405e8bb4bec9cca30537