Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Marion Helsmoortel"'
Autor:
Xavier Contreras, David Depierre, Charbel Akkawi, Marina Srbic, Marion Helsmoortel, Maguelone Nogaret, Matthieu LeHars, Kader Salifou, Alexandre Heurteau, Olivier Cuvier, Rosemary Kiernan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Pervasive transcription of the human genome generates an abundance of RNAs that must be processed and degraded. The nuclear RNA exosome is the main RNA degradation machinery in the nucleus. However, nuclear exosome must be recruited to its s
Externí odkaz:
https://doaj.org/article/dead10e00ef946ad9aa32b08b538a230
Autor:
Xavier Contreras, Kader Salifou, Gabriel Sanchez, Marion Helsmoortel, Emmanuelle Beyne, Lisa Bluy, Stéphane Pelletier, Emilie Rousset, Sylvie Rouquier, Rosemary Kiernan
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006950 (2018)
Expression from the HIV-1 LTR can be repressed in a small population of cells, which contributes to the latent reservoir. The factors mediating this repression have not been clearly elucidated. We have identified a network of nuclear RNA surveillance
Externí odkaz:
https://doaj.org/article/408ec278d3734468aa37e065087d9fc1
Autor:
Shuji Sakamoto, Victor Mac, Claudio Lorenzi, Rosemary Kiernan, Jérôme Barbier, William Ritchie, Takuma Higuchi, Giuseppa Grasso, Maxime Bello, Marion Helsmoortel, Gabriel Sanchez
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (12), pp.6874-6888. ⟨10.1093/nar/gkaa386⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (12), pp.6874-6888. ⟨10.1093/nar/gkaa386⟩
MicroRNAs (miRNAs) are predicted to regulate the expression of >60% of mammalian genes and play fundamental roles in most biological processes. Deregulation of miRNA expression is a hallmark of most cancers and further investigation of mechanisms con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9d1c120636569ae4c1aae0101b17fe
http://europepmc.org/articles/PMC7337520
http://europepmc.org/articles/PMC7337520
Autor:
Kalina Timcheva, Solenne Dufour, Leila Touat-Todeschini, Callum Burnard, Marie-Christine Carpentier, Florent Chuffart, Rémy Merret, Marion Helsmoortel, Sabrina Ferré, Aude Grézy, Yohann Couté, Sophie Rousseaux, Saadi Khochbin, Claire Vourc’h, Cécile Bousquet-Antonelli, Rosemary Kiernan, Daphné Seigneurin-Berny, André Verdel
Publikováno v:
Cell Reports
Cell Reports, 2022, 41 (11), pp.111784. ⟨10.1016/j.celrep.2022.111784⟩
Cell Reports, 2022, 41 (11), pp.111784. ⟨10.1016/j.celrep.2022.111784⟩
Heat stress (HS) induces a cellular response leading to profound changes in gene expression. Here, we show that human YTHDC1, a reader of N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990d0e2b6e7ebd27fcb4e035791d8ad4
https://doi.org/10.1016/j.celrep.2022.111784
https://doi.org/10.1016/j.celrep.2022.111784
Autor:
Celine Franckhauser, Poornima Basavarajaiah, Olivier Cuvier, Rosemary Kiernan, Victor Mac, Emmanuelle Beyne, Marion Helsmoortel, David Depierre, Jérôme Déjardin, Callum Burnard, Giuseppa Grasso, Sylvie Rouquier, Xavier Contreras, Kader Salifou
Publikováno v:
Science Advances
Chromatin-associated MRN protects highly transcribing genes from genomic instability.
MRN-MDC1 plays a central role in the DNA damage response (DDR) and repair. Using proteomics of isolated chromatin fragments, we identified DDR factors, such as
MRN-MDC1 plays a central role in the DNA damage response (DDR) and repair. Using proteomics of isolated chromatin fragments, we identified DDR factors, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155859723d2783f5349c8c2acb3d001f
https://doi.org/10.1101/2020.05.27.118638
https://doi.org/10.1101/2020.05.27.118638
Autor:
Claudio Lorenzi, Gabriel Sanchez, Shuji Sakamoto, William Ritchie, Jérôme Barbier, Giuseppa Grasso, Marion Helsmoortel, Rosemary Kiernan, Maxime Bello, Takuma Higuchi
MicroRNAs are predicted to regulate the expression of more than 60% of mammalian genes and play fundamental roles in most biological processes. Deregulation of miRNA expression is a hallmark of most cancers and further investigation of mechanisms con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f24dd8287d763b4a6e40c6ae1d4d74
Autor:
Stéphane Pelletier, Lisa Bluy, Gabriel Sanchez, Xavier Contreras, Emmanuelle Beyne, Marion Helsmoortel, Emilie Rousset, Kader Salifou, Sylvie Rouquier, Rosemary Kiernan
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2018, 14 (3), pp.e1006950. ⟨10.1371/journal.ppat.1006950⟩
PLoS Pathogens, Vol 14, Iss 3, p e1006950 (2018)
PLoS Pathogens, Public Library of Science, 2018, 14 (3), pp.e1006950. ⟨10.1371/journal.ppat.1006950⟩
PLoS Pathogens, Vol 14, Iss 3, p e1006950 (2018)
Expression from the HIV-1 LTR can be repressed in a small population of cells, which contributes to the latent reservoir. The factors mediating this repression have not been clearly elucidated. We have identified a network of nuclear RNA surveillance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ef6f6f239bdf78d55b9379ca66c3af
https://hal.archives-ouvertes.fr/hal-01741841
https://hal.archives-ouvertes.fr/hal-01741841
Autor:
Sylvie Rouquier, Muyan Cai, Pierre Giraud, Rosemary Kiernan, Lisa Bluy, Olivier Deas, Gabriel Sanchez, Shuji Sakamoto, Jean Gabriel Judde, William Ritchie, Xavier Contreras, Dan Xie, Jérôme Barbier, Xin Chen, Gangjun Yuan, Rima Nait-Saidi, Takuma Higuchi, Zi-Hao Feng, Marion Helsmoortel
Publikováno v:
Cell Research
Cell Research, Nature Publishing Group, 2018, 28 (5), pp.556-571. ⟨10.1038/s41422-018-0016-8⟩
Cell Research, Nature Publishing Group, 2018, 28 (5), pp.556-571. ⟨10.1038/s41422-018-0016-8⟩
International audience; Reduced expression of DICER, a key enzyme in the miRNA pathway, is frequently associated with aggressive, invasive disease, and poor survival in various malignancies. Regulation of DICER expression is, however, poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5902423a58e325295508aa180b60835
https://pubmed.ncbi.nlm.nih.gov/29563539
https://pubmed.ncbi.nlm.nih.gov/29563539