Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Marion Espéli"'
Autor:
David Fandrei, Tony Huynh, Marie Sébert, Lorea Aguinaga, Valeria Bisio, Rathana Kim, Emmanuelle Clappier, Marion Espéli, Karl Balabanian, Hélène Moins-Teisserenc, Antoine Toubert, Nicolas Dulphy, Pierre Fenaux, Lionel Adès, Lin-Pierre Zhao
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-5 (2023)
Externí odkaz:
https://doaj.org/article/88c7fccd841544b4a98e51be7f98109a
Autor:
Adrienne Anginot, Julie Nguyen, Zeina Abou Nader, Vincent Rondeau, Amélie Bonaud, Maria Kalogeraki, Antoine Boutin, Julia P. Lemos, Valeria Bisio, Joyce Koenen, Lea Hanna Doumit Sakr, Amandine Picart, Amélie Coudert, Sylvain Provot, Nicolas Dulphy, Michel Aurrand-Lions, Stéphane J. C. Mancini, Gwendal Lazennec, David H. McDermott, Fabien Guidez, Claudine Blin-Wakkach, Philip M. Murphy, Martine Cohen-Solal, Marion Espéli, Matthieu Rouleau, Karl Balabanian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mouse model. Imbalanced bone ti
Externí odkaz:
https://doaj.org/article/71e743108c284ff4a7d508b10f487735
Autor:
Pierre-Edouard Debureaux, Nathalie Forgeard, Dikelele Elessa, Stéphanie Harel, Laurent Frenzel, Bruno Royer, Alexis Talbot, Sylvain Choquet, Frederic Davi, Florence Nguyen-Khac, Wendy Cuccuini, Morgane Cheminant, Clotilde Bravetti, Gregory Lazarian, Sophie Kaltenbach, Olivier Hermine, Damien Roos-Weil, Marion Espéli, Karl Balabanian, Bertrand Arnulf
Publikováno v:
Haematologica, Vol 109, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/ab84babbb7c54bb5a1d146187514f7eb
Autor:
Laurent Beuret, Simon-Pierre Fortier-Beaulieu, Vincent Rondeau, Sophie Roy, Nicolas Houde, Karl Balabanian, Marion Espéli, Jean Charron
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Several studies have established the crucial role of the extracellular signal–regulated kinase (ERK)/mitogen-activated protein kinase pathway in hematopoietic cell proliferation and differentiation. MEK1 and MEK2 phosphorylate and activate ERK1 and
Externí odkaz:
https://doaj.org/article/551a2b37afce409691d6b39eaab6cea2
Autor:
Catherine Ouk, Lilian Roland, Nathalie Gachard, Stéphanie Poulain, Christelle Oblet, David Rizzo, Alexis Saintamand, Quentin Lemasson, Claire Carrion, Morgane Thomas, Karl Balabanian, Marion Espéli, Marie Parrens, Isabelle Soubeyran, Mélanie Boulin, Nathalie Faumont, Jean Feuillard, Christelle Vincent-Fabert
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Activating mutations of MYD88 (MYD88L265P being the far most frequent) are found in most cases of Waldenström macroglobulinemia (WM) as well as in various aggressive B-cell lymphoma entities with features of plasma cell (PC) differentiation, such as
Externí odkaz:
https://doaj.org/article/6ae2c3b7bfc345f6b7a93a374d068805
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The bone marrow is a complex ecosystem in which hematopoietic and non-hematopoietic cells reside. In this review, we discuss the bone marrow niches in mice that facilitate the survival, maintenance, and differentiation of cells of hematopoietic origi
Externí odkaz:
https://doaj.org/article/497b4584edb04054b84eca4961e85ff2
Autor:
Marion Espéli, Rachael Bashford-Rogers, John M. Sowerby, Nagham Alouche, Limy Wong, Alice E. Denton, Michelle A. Linterman, Kenneth G. C. Smith
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The inhibitory receptor, FcγRIIb, is reported to limit autoimmune B cell response. Here the authors show that FcγRIIb has a dual role in both human and mouse, with reduced FcγRIIb expression or function associated with enhanced pre-immune B cell t
Externí odkaz:
https://doaj.org/article/79eaab1ad06c4833bed4609c3c0f95a6
Autor:
Amélie Bonaud, Simon Clare, Valeria Bisio, John M. Sowerby, Shugang Yao, Hanne Ostergaard, Karl Balabanian, Kenneth G. C. Smith, Marion Espéli
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The generation of a potent humoral immune response by B cells relies on the integration of signals induced by the B cell receptor, toll-like receptors and both negative and positive co-receptors. Several reports also suggest that integrin signaling p
Externí odkaz:
https://doaj.org/article/f2a5a03a38854997b6ab77d7411f784f
Autor:
Vincent Biajoux, Jessica Natt, Christelle Freitas, Nagham Alouche, Antoine Sacquin, Patrice Hemon, Françoise Gaudin, Nicolas Fazilleau, Marion Espéli, Karl Balabanian
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 193-205 (2016)
CXCR4 plays a central role in B cell immune response, notably by promoting plasma cell (PC) migration and maintenance in the bone marrow (BM). Gain-of-function mutations in CXCR4 affecting receptor desensitization have been reported in the rare immun
Externí odkaz:
https://doaj.org/article/e0aee90f1516444891091500fdd34ed5
Autor:
Dorian Obino, Luc Fetler, Andrea Soza, Odile Malbec, Juan José Saez, Mariana Labarca, Claudia Oyanadel, Felipe Del Valle Batalla, Nicolas Goles, Aleksandra Chikina, Danielle Lankar, Fabián Segovia-Miranda, Camille Garcia, Thibaut Léger, Alfonso Gonzalez, Marion Espéli, Ana-Maria Lennon-Duménil, Maria-Isabel Yuseff
Publikováno v:
Cell Reports, Vol 25, Iss 11, Pp 3110-3122.e6 (2018)
Summary: Complete activation of B cells relies on their capacity to extract tethered antigens from immune synapses by either exerting mechanical forces or promoting their proteolytic degradation through lysosome secretion. Whether antigen extraction
Externí odkaz:
https://doaj.org/article/cad33fed519b4f1fb48c44bd48bb7a3b