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Publikováno v:
Journal of Neurochemistry.
Autor:
Marion Edmonds Smith
Publikováno v:
Neurochemical Research. 25:1453-1456
Autor:
Marion Edmonds Smith
Publikováno v:
Neurochemical Research. 24:261-268
In the cell-mediated demyelinating diseases such as experimental allergic encephalomyelitis and multiple sclerosis, as well as their peripheral nerve counterparts, the phagocytic cells are the agent of myelin destruction. Both resident microglia and
Autor:
Marion Edmonds Smith
Publikováno v:
Journal of Lipid Research, Vol 14, Iss 5, Pp 541-551 (1973)
A survey of differences in composition and metabolism of myelin from five areas of the central nervous system was made in brain and spinal cord slices of the rat from 20 days to 20 months postnatal age. Purified myelin from the forebrain areas showed
Externí odkaz:
https://doaj.org/article/872e6b9d80eb403fb1d5c1081e8603f3
Publikováno v:
Journal of Neuroscience Research. 54:68-78
Certain cytokines are believed to play a key role in the development of autoimmune demyelinating diseases. Little is known, however, about the effects of these cytokines in the regulation of the key event in myelin destruction, the phagocytosis of my
Publikováno v:
Neurochemical Research. 23:427-434
Peripheral macrophages infiltrating the central nervous system and resident microglia phagocytize myelin in cell-mediated demyelinating diseases, including experimental autoimmune encephalomyelitis and multiple sclerosis. A cascade of cytokines is be
Autor:
Brigit A. DeJong, Marion Edmonds Smith
Publikováno v:
Neurochemical Research. 22:491-498
The mechanisms for phagocytosis of myelin in cell-mediated demyelinating diseases have not been clarified. We have previously shown with cultured phagocytic cells that myelin opsonized with antiserum to myelin constituents is phagocytized in much hig
Publikováno v:
Glia. 14:216-224
Activation of astrocytes and hypertrophy of their processes is a result of a number of pathological conditions in the central nervous system. Astrocytic gliosis is especially prominent in multiple sclerosis (MS), where astrocytic fibers form a dense
Autor:
Marion Edmonds Smith
Publikováno v:
Neurochemical Research. 19:1039-1045
It has been known for some time that P0, the major intrinsic protein in PNS myelin, contains sulfate. The position of sulfate has been described for beef PNS myelin, but rat PNS myelin differs somewhat from that of the beef, therefore an investigatio