A Method to Correlate mRNA Expression Datasets Obtained from Fresh Frozen and Formalin-Fixed, Paraffin-Embedded Tissue Samples: A Matter of Thresholds.

Autor: Dana A M Mustafa, Anieta M Sieuwerts, Marcel Smid, Vania de Weerd, Marcel van der Weiden, Marion E Meijer-van Gelder, John W M Martens, John A Foekens, Johan M Kros

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144097 (2015)

Gene expression profiling of tumors is a successful tool for the discovery of new cancer biomarkers and potential targets for the development of new therapeutic strategies. Reliable profiling is preferably performed on fresh frozen (FF) tissues in wh

Externí odkaz: https://doaj.org/article/0f912b0987de47b283065af2a91fc30f

Supplementary Table S2 from Association of DNA Methylation of Phosphoserine Aminotransferase with Response to Endocrine Therapy in Patients with Recurrent Breast Cancer

Autor: John A. Foekens, Sabine Maier, Manfred Schmitt, Jan G.M. Klijn, Marion Kiechle, Heinz Höfler, Alexander Olek, Christian Piepenbrock, Marion E. Meijer-Van Gelder, Henk Portengen, Anieta M. Sieuwerts, Joan Bolt-de Vries, Antje Kluth, Fabian Model, Nadia Harbeck, Maxime P. Look, Thomas Koenig, Inko Nimmrich, John W.M. Martens

Supplementary Table S2 from Association of DNA Methylation of Phosphoserine Aminotransferase with Response to Endocrine Therapy in Patients with Recurrent Breast Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc72d9c48cd8ac012793249eb69a480
https://doi.org/10.1158/0008-5472.22363227

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

Autor: Marcel Smid, F. Germán Rodríguez-González, Anieta M. Sieuwerts, Roberto Salgado, Wendy J. C. Prager-Van der Smissen, Michelle van der Vlugt-Daane, Anne van Galen, Serena Nik-Zainal, Johan Staaf, Arie B. Brinkman, Marc J. van de Vijver, Andrea L. Richardson, Aquila Fatima, Kim Berentsen, Adam Butler, Sancha Martin, Helen R. Davies, Reno Debets, Marion E. Meijer-Van Gelder, Carolien H. M. van Deurzen, Gaëtan MacGrogan, Gert G. G. M. Van den Eynden, Colin Purdie, Alastair M. Thompson, Carlos Caldas, Paul N. Span, Peter T. Simpson, Sunil R. Lakhani, Steven Van Laere, Christine Desmedt, Markus Ringnér, Stefania Tommasi, Jorunn Eyford, Annegien Broeks, Anne Vincent-Salomon, P. Andrew Futreal, Stian Knappskog, Tari King, Gilles Thomas, Alain Viari, Anita Langerød, Anne-Lise Børresen-Dale, Ewan Birney, Hendrik G. Stunnenberg, Mike Stratton, John A. Foekens, John W. M. Martens

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

Recent studies using in depth DNA sequencing techniques led to the identification of cancer driver genes but mainly focused on the effect on their expression. Here, the authors analyse 266 cases of breast cancer and report gene expression signatures

Externí odkaz: https://doaj.org/article/0b80834b0f74411a8fac98a9ae2db59b

The 29.5 kb APOBEC3B Deletion Polymorphism Is Not Associated with Clinical Outcome of Breast Cancer

Autor: John W.M. Martens, Marion E. Meijer-van Gelder, Antoinette Hollestelle, John A. Foekens, Maxime P. Look, Anieta M. Sieuwerts, Jingjing Liu, Michelle van der Vlugt-Daane

Publikováno v: PLoS One (print), 11(8):e0161731. Public Library of Science
PLoS ONE, Vol 11, Iss 8, p e0161731 (2016)
PLoS ONE

Increased APOBEC3B mRNA levels are associated with a hypermutator phenotype and poor prognosis in ER-positive breast cancer patients. In addition, a 29.5 kb deletion polymorphism of APOBEC3B, resulting in an APOBEC3A-B hybrid transcript, has been ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594459c3e13e1b5819041da06b40e441
https://pure.eur.nl/en/publications/f5777e54-9b72-40b2-9300-b9661f3c6755

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

Autor: John W.M. Martens, Nuri A. Temiz, Paul N. Span, Rachel Isaksson Vogel, Kelly LaPara, Anieta M. Sieuwerts, Reuben S. Harris, Marion E. Meijer-van Gelder, Amy M. Molan, Fred C.G.J. Sweep, Gabriel J. Starrett, Brandon Leonard, Douglas Yee, John A. Foekens, Emily K. Law

Publikováno v: Science Advances, 2, 10, pp. e1601737
ResearcherID
Science Advances, 2, e1601737
Science Advances
Science advances, 2(10):e1601737. American Association for the Advancement of Science

An antiviral enzyme promotes drug resistance in breast cancer.
Breast tumors often display extreme genetic heterogeneity characterized by hundreds of gross chromosomal aberrations and tens of thousands of somatic mutations. Tumor evolution is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4315799ce18fdef4c51312f44e19a275
https://hdl.handle.net/2066/171645