Dynamic shift from CD85j/ILT-2 to NKG2D NK receptor expression pattern on human decidual NK during the first trimester of pregnancy.

Autor: Romain Marlin, Marion Duriez, Nadia Berkane, Claire de Truchis, Yoann Madec, Marie-Anne Rey-Cuille, Jean-Saville Cummings, Claude Cannou, Heloise Quillay, Françoise Barré-Sinoussi, Marie-Thérèse Nugeyre, Elisabeth Menu

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30017 (2012)

During the first trimester of human pregnancy, Natural Killer (NK) cells of the maternal uterine mucosa (e.g. decidua) have a unique phenotype and are involved in crucial physiological processes during pregnancy. We investigated whether modifications

Externí odkaz: https://doaj.org/article/dafd0e5cdbb4458fb7179cd85b36cff7

A 3D Human Liver Model of Nonalcoholic Steatohepatitis

Autor: Sandrine Roche, Zsolt Bocskei, Michel Didier, Anne-Céline Le Fèvre, Cécile Orsini, Lucile Hoet, Jean-Claude Guillemot, Tamara Slavnic, Corinne Rocher, Aimo Kannt, Xavier Vigé, Vincent Mikol, Marie-Dominique Bock, Agnès Jacquet, Gilles Haussy, Valérie Martin, Marion Duriez

Publikováno v: Journal of Clinical and Translational Hepatology

Background and Aims: To better understand nonalcoholic steatohepatitis (NASH) disease progression and to evaluate drug targets and compound activity, we undertook the development of an in vitro 3D model to mimic liver architecture and the NASH enviro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28dbda09c771b8862ebc2d67273f4e6
http://europepmc.org/articles/PMC7782122

NK cells limit therapeutic vaccine–induced CD8+T cell immunity in a PD-L1–dependent manner

Autor: Mariana O. Diniz, Anna Schurich, Senthil K. Chinnakannan, Marion Duriez, Kerstin A. Stegmann, Jessica Davies, Stephanie Kucykowicz, Kornelija Suveizdyte, Oliver E. Amin, Frances Alcock, Tamsin Cargill, Eleanor Barnes, Mala K. Maini

Publikováno v: Diniz, M O, Schurich, A, Chinnakannan, S K, Duriez, M, Stegmann, K A, Davies, J, Kucykowicz, S, Suveizdyte, K, Amin, O E, Alcock, F, Cargill, T, Barnes, E & Maini, M K 2022, ' NK cells limit therapeutic vaccine–induced CD8 + T cell immunity in a PD-L1–dependent manner ', Science Translational Medicine, vol. 14, no. 640, eabi4670 . https://doi.org/10.1126/scitranslmed.abi4670

A better understanding of mechanisms that regulate CD8 + T cell responses to therapeutic vaccines is needed to develop approaches to enhance vaccine efficacy for chronic viral infections and cancers. We show here that NK cell depletion enhanced antig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8b8a4db370a666b93d46c902bd6ad2
https://kclpure.kcl.ac.uk/ws/files/175375334/NK_cells_limit_therapeutic_DINIZ_Publishedonline13April2022_GREEN_AAM.pdf

Hepatitis B virus HBx protein impairs liver regeneration through enhanced expression of IL-6 in transgenic mice

Autor: Dina Kremsdorf, Céline Lamant, Patrick Soussan, Marion Duriez, James Ahodantin, Hélène Massinet, Ivan Quetier, Eric Giang, Marie-Noëlle Brunelle, Nicolas Brezillon

Publikováno v: Journal of Hepatology. 59:285-291

Background & Aims Conflicting results have been reported regarding the impact of hepatitis B virus X protein (HBx) expression on liver regeneration triggered by partial hepatectomy (PH). In the present report we investigated the mechanisms by which H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8841cd2de23409d091308207979bda2c
https://doi.org/10.1016/j.jhep.2013.03.021

The local environment orchestrates mucosal decidual macrophage differentiation and substantially inhibits HIV-1 replication

Autor: Héloïse Quillay, H. El Costa, Marion Duriez, J Ighil, Romain Marlin, Françoise Barré-Sinoussi, Fahd Benjelloun, C. de Truchis, Elisabeth Menu, Claude Cannou, M. Rahmati, Marie-Thérèse Nugeyre

Publikováno v: Mucosal Immunology
Mucosal Immunology, Nature Pub. Group, 2016, 9 (3), pp.634-46. ⟨10.1038/mi.2015.87⟩
Mucosal Immunology, 2016, 9 (3), pp.634-46. ⟨10.1038/mi.2015.87⟩

International audience; Macrophages from the decidua basalis (dM), the main uterine mucosa during pregnancy, are weakly permissive to HIV-1 infection. Here, we investigated the mechanisms underlying this natural control. We show, by using freshly pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764efd7d7f7fb011bb2f2f76d831e437
https://hal-pasteur.archives-ouvertes.fr/pasteur-01453433