Zobrazeno 1 - 10 of 107 pro vyhledávání: '"Marion Dorsch"'
1
Akademický článek
Evaluation of STK17B as a cancer immunotherapy target utilizing highly potent and selective small molecule inhibitors
Autor: Felix Scheuplein, Florian Renner, John E. Campbell, Robert Campbell, Chris De Savi, Jan Eckmann, Holger Fischer, Jie Ge, Luke Green, Peter Jakob, Joseph L. Kim, Caitlin Kinkema, Katie McGinn, Ricardo Medina, Annemarie Müller, Nisha Perez, Emanuele Perola, Yoav Timsit, Tary Traore, Ulrike Hopfer, Stefka Tyanova, Manuel Tzouros, Ruduan Wang, Richard Woessner, Marion Dorsch, James R. Bischoff
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
IntroductionThe serine/threonine kinase 17B (STK17B) is involved in setting the threshold for T cell activation and its absence sensitizes T cells to suboptimal stimuli. Consequently, STK17B represents an attractive potential target for cancer immuno
Externí odkaz: https://doaj.org/article/301b248df8e548fc8ca6b2a6315e5115
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2
Akademický článek
Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma
Autor: Stefanie S. Schalm, Erin O’Hearn, Kevin Wilson, Timothy P. LaBranche, Grace Silva, Zhuo Zhang, Lucian DiPietro, Neil Bifulco, Richard Woessner, Nicolas Stransky, Darshan Sappal, Robert Campbell, Riadh Lobbardi, Michael Palmer, Joseph Kim, Chaoyang Ye, Marion Dorsch, Christoph Lengauer, Timothy Guzi, Vivek Kadambi, Andrew Garner, Klaus P. Hoeflich
Publikováno v: Gastro Hep Advances, Vol 2, Iss 3, Pp 307-321 (2023)
Background and Aims: Fibrolamellar carcinoma (FLC) is a rare, difficult-to-treat liver cancer primarily affecting pediatric and adolescent patients, and for which precision medicine approaches have historically not been possible. The DNAJB1-PRKACA ge
Externí odkaz: https://doaj.org/article/2154c1b576ce47429fad42ed3d908a8f
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3
Akademický článek
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
Autor: Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol bios
Externí odkaz: https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77
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4
Akademický článek
Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH
Autor: Eric L. Allen, Danielle B. Ulanet, David Pirman, Christopher E. Mahoney, John Coco, Yaguang Si, Ying Chen, Lingling Huang, Jinmin Ren, Sung Choe, Michelle F. Clasquin, Erin Artin, Zi Peng Fan, Giovanni Cianchetta, Joshua Murtie, Marion Dorsch, Shengfang Jin, Gromoslaw A. Smolen
Publikováno v: Cell Reports, Vol 17, Iss 3, Pp 876-890 (2016)
Although aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained challenging. Here, we conducted an siRNA screen focusing on enzymes involved in the tricarboxy
Externí odkaz: https://doaj.org/article/038a8ba083f6473f859242fde11df665
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5
Akademický článek
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
Autor: Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks
Publikováno v: Cell Reports, Vol 15, Iss 3, Pp 574-587 (2016)
Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP). Here, we used shRNA screening and identified the metabolic enzyme, met
Externí odkaz: https://doaj.org/article/bd77de65b22f4da89618bc5269d7f141
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6
Akademický článek
Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.
Autor: Danielle B Ulanet, Kiley Couto, Abhishek Jha, Sung Choe, Amanda Wang, Hin-Koon Woo, Mya Steadman, Byron DeLaBarre, Stefan Gross, Edward Driggers, Marion Dorsch, Jonathan B Hurov
Publikováno v: PLoS ONE, Vol 9, Iss 12, p e115144 (2014)
Recent work has highlighted glutaminase (GLS) as a key player in cancer cell metabolism, providing glutamine-derived carbon and nitrogen to pathways that support proliferation. There is significant interest in targeting GLS for cancer therapy, althou
Externí odkaz: https://doaj.org/article/0bc829c77b264c57a2de6ffb300eab3c
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