Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Marion Delenclos"'
Autor:
Jeremy D. Burgess, Danilyn Amerna, Emily S. Norton, Tammee M. Parsons, Ralph B. Perkerson, Ayman H. Faroqi, Zbigniew K. Wszolek, Hugo Guerrero Cazares, Takahisa Kanekiyo, Marion Delenclos, Pamela J. McLean
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Mesenchymal stromal cells (MSCs) have a dynamic secretome that plays a critical role in tissue repair and regeneration. However, studying the MSC secretome in mixed-culture disease models remains challenging. This study aimed to d
Externí odkaz:
https://doaj.org/article/26b95de1f2774f8b9a09c407294b15bf
Autor:
Sara J. Fagen, Jeremy D. Burgess, Melina J. Lim, Danilyn Amerna, Zeynep B. Kaya, Ayman H. Faroqi, Priyanka Perisetla, Natasha N. DeMeo, Iva Stojkovska, Drew J. Quiriconi, Joseph R. Mazzulli, Marion Delenclos, Suelen L. Boschen, Pamela J. McLean
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundIntracytoplasmic inclusions comprised of aggregated alpha-synuclein (αsyn) represent a key histopathological feature of neurological disorders collectively termed “synucleinopathies,” which includes Parkinson’s disease (PD). Mutation
Externí odkaz:
https://doaj.org/article/2969623c54014de0ac6153319e52265f
Autor:
Melina J. Lim, Suelen L. Boschen, Aishe Kurti, Monica Castanedes Casey, Virginia R. Phillips, John D. Fryer, Dennis Dickson, Karen R. Jansen-West, Leonard Petrucelli, Marion Delenclos, Pamela J. McLean
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2863 (2023)
Lewy body dementia (LBD) is an often misdiagnosed and mistreated neurodegenerative disorder clinically characterized by the emergence of neuropsychiatric symptoms followed by motor impairment. LBD falls within an undefined range between Alzheimer’s
Externí odkaz:
https://doaj.org/article/3baa64b6498643d1a8787bb092b331cf
Autor:
Jae-Hyeon Park, Jeremy D. Burgess, Ayman H. Faroqi, Natasha N. DeMeo, Fabienne C. Fiesel, Wolfdieter Springer, Marion Delenclos, Pamela J. McLean
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background Misfolding and aggregation of the presynaptic protein alpha-synuclein (αsyn) is a hallmark of Parkinson’s disease (PD) and related synucleinopathies. Although predominantly localized in the cytosol, a body of evidence has shown
Externí odkaz:
https://doaj.org/article/60b1e65ccc0c4003b48d0247a385a231
Autor:
Jichao Sun, Jared Carlson-Stevermer, Utpal Das, Minjie Shen, Marion Delenclos, Amanda M. Snead, So Yeon Koo, Lina Wang, Dianhua Qiao, Jonathan Loi, Andrew J. Petersen, Michael Stockton, Anita Bhattacharyya, Mathew V. Jones, Xinyu Zhao, Pamela J. McLean, Andrew A. Sproul, Krishanu Saha, Subhojit Roy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Gene editing strategies are typically designed to correct mutant genes, but most neurodegenerative diseases are sporadic. Here the authors describe a strategy to selectively edit the C-terminus of APP and attenuate amyloid-β production, while upregu
Externí odkaz:
https://doaj.org/article/9b7514e64c5f429f8af27f9559663d3c
Autor:
Marion Delenclos, Ayman H. Faroqi, Mei Yue, Aishe Kurti, Monica Castanedes-Casey, Linda Rousseau, Virginia Phillips, Dennis W. Dickson, John D. Fryer, Pamela J. McLean
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-14 (2017)
Abstract Abnormal accumulation of alpha-synuclein (αsyn) is a pathological hallmark of Lewy body related disorders such as Parkinson’s disease and Dementia with Lewy body disease. During the past two decades, a myriad of animal models have been de
Externí odkaz:
https://doaj.org/article/bf8ea4c6aa7c4d3c9dbbb57c8bb22772
Autor:
Axel D. Meneses, Shunsuke Koga, Zonghua Li, Justin O'Leary, Fuyao Li, Kai Chen, Aya Murakami, Wenhui Qiao, Aishe Kurti, Michael G. Heckman, Launia White, Manling Xie, Yixing Chen, Nicole A. Finch, Melina J. Lim, Marion Delenclos, Michael A. DeTure, Cynthia Linares, Nicholas B. Martin, Tadafumi C. Ikezu, Marka M. van Blitterswijk, Long‐Jun Wu, Pamela J. McLean, Rosa Rademakers, Owen A. Ross, Dennis W. Dickson, Guojun Bu, Na Zhao
Publikováno v:
Annals of Neurology. 93:830-843
Recent evidence supports a link between increased TDP-43 burden and the presence of an APOE4 gene allele in Alzheimer's disease (AD); however, it is difficult to conclude the direct effect of APOE on TDP-43 pathology due to the presence of mixed AD p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abc16fcf71fc09db1e54ab7638e76af
https://doi.org/10.1002/ana.26580
https://doi.org/10.1002/ana.26580
In Vivo Detection of Extracellular Adenosine Triphosphate in a Mouse Model of Traumatic Brain Injury
Autor:
Francesco Di Virgilio, Melina J. Lim, Pamela J. McLean, Emma C. Kee, Ridong Chen, Jeremy D. Burgess, Jannifer H. Lee, Ayman H. Faroqi, Marion Delenclos
Publikováno v:
Journal of Neurotrauma
Traumatic brain injury (TBI) is traditionally characterized by primary and secondary injury phases, both contributing to pathological and morphological changes. The mechanisms of damage and chronic consequences of TBI remain to be fully elucidated, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fb17de9b191dfbd4088f253a7dadd1
https://doi.org/10.1089/neu.2020.7226
https://doi.org/10.1089/neu.2020.7226
Autor:
Pamela J. McLean, Agaristi Lamprokostopoulou, Jeremy D. Burgess, Kostas Vekrellis, Marion Delenclos, Tiago F. Outeiro
Publikováno v:
J Neurochem
Misfolding and aggregation of alpha-synuclein (α-synuclein) with concomitant cytotoxicity is a hallmark of Lewy body related disorders such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Although it plays a pivotal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec04a6d72de6a8f082f52a9564cbb0ac
https://pubmed.ncbi.nlm.nih.gov/31265132
https://pubmed.ncbi.nlm.nih.gov/31265132
Autor:
Mary D. Davis, Chia Chen Liu, Joshua Knight, Aishe Kurti, Fuyao Li, Guojun Bu, Cynthia Linares, Wenhui Qiao, John D. Fryer, Olivia N. Attrebi, Yingxue Ren, Marion Delenclos, Jiaying Zheng, Yan W. Asmann, Dennis W. Dickson, Pamela J. McLean, Owen A. Ross, Na Zhao, Francis Shue, Axel D. Meneses, Berkiye Sonustun, Yuka A. Martens, Yixing Chen, Alexandra J. Van Ingelgom
Publikováno v:
Sci Transl Med
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease mainly by driving amyloid-β pathology. Recently, APOE4 has also been found to be a genetic risk factor for Lewy body dementia (LBD), whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62676212be5002c8a8702f5c6ae0bc0
https://pubmed.ncbi.nlm.nih.gov/32107475
https://pubmed.ncbi.nlm.nih.gov/32107475