Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Marion C. James"'
1
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence
Autor: Susana Llanos, Nelleke A. Gruis, Karen H. Vousden, Paula A. Clark, Stewart Bates, Gordon Peters, Margarida Ruas, Marion C. James, Janice Rowe, Radost Vatcheva, Sharon Brookes, Martine Lomax, Nico P.M. Smit, David A.D. Parry, Wilma Bergman
Publikováno v: The EMBO Journal. 21:2936-2945
The CDKN2A tumour suppressor locus encodes two distinct proteins, p16(INK4a) and p14(ARF), both of which have been implicated in replicative senescence, the state of permanent growth arrest provoked in somatic cells by aberrant proliferative signals
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf85f4a2b400511fc45a3b48b416a754
https://doi.org/10.1093/emboj/cdf289
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2
Regulation of the interferon-inducible eIF-2α protein kinase by small RNAs
Autor: Vivienne J. Tilleray, Marion C. James, Volker Matys, Ian W. Jeffrey, Tyson V. Sharp, Androulla Elia, Andrea Schofield, Michael J. Clemens, Ken Laing
Publikováno v: Biochimie. 76:770-778
This review describes the structure and function of the double-stranded RNA-dependent protein kinase (PKR) and its interaction with RNA activators and inhibitors. The abilities of small virally-encoded RNAs such as VAI RNA of adenovirus, the Epstein-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d3a07d0dd25f9e28da12c724bac5b0
https://doi.org/10.1016/0300-9084(94)90081-7
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3
E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells
Autor: Paula A. Clark, Francesca J. Stott, Ana Gutierrez del Arroyo, Selma El Messaoudi, Marion C. James, Adrian P. Bracken, Gordon Peters, Kristian Helin
Publikováno v: Europe PubMed Central
University of Copenhagen
Scopus-Elsevier
The ARF protein, encoded by alternate exon usage within the CDKN2A locus, provides a link between the retinoblastoma (pRb) and p53 tumor suppressor pathways. Agents that disable pRb or otherwise impinge on the E2F family of transcription factors indu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a27bb1f96dd3fba5b2cce0f6d0cfe94
https://pubmed.ncbi.nlm.nih.gov/17912037
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4
Alternative product of the p16/CKDN2A locus connects the Rb and p53 tumor suppressors
Autor: Gordon Peters, Marion C. James
Publikováno v: Progress in Cell Cycle Research ISBN: 9781461369097
Two distinct products are specified by the CDKN2A locus, the p16INK4a cyclin dependent kinase inhibitor and a protein termed ARF. ARF has been shown to bind to the Mdm2-p53 complex, resulting in stabilisation of both proteins, and a feedback loop exi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::feecf32c890b3db27f7af9df56956e62
https://doi.org/10.1007/978-1-4615-4253-7_7
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5
Translational control by the La antigen. Structure requirements for rescue of the double-stranded RNA-mediated inhibition of protein synthesis
Autor: Ian W. Jeffrey, Michael J. Clemens, José Thijssen, Ger J. M. Pruijn, Marion C. James
Publikováno v: European Journal of Biochemistry, 266, 1, pp. 151-62
European Journal of Biochemistry, 266, 151-62
Contains fulltext : 184894.pdf (Publisher’s version ) (Closed access) The La antigen is a protein which can bind both single-stranded and double-stranded forms of RNA and has regulatory effects on gene expression at the levels of transcription and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56eb6039931c78f12d94031957a0147d
https://hdl.handle.net/2066/184894
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6
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
Autor: Francesca J. Stott, Eiji Hara, Marion C. James, Beth B. McConnell, Ignacio Palmero, Maria Starborg, Sharon Brookes, Stewart Bates, Gordon Peters, Kevin M. Ryan, Karen H. Vousden
The two distinct proteins encoded by the CDKN2A locus are specified by translating the common second exon in alternative reading frames. The product of the alpha transcript, p16(INK4a), is a recognized tumour suppressor that induces a G1 cell cycle a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2ae33cc3c94fd1b411c744ee91a70a
https://europepmc.org/articles/PMC1170828/
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7
The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA
Autor: Ian W. Jeffrey, Ger J. M. Pruijn, Michael J. Clemens, Qiurong Xao, Marion C. James, Walther J. van Venrooij, Tyson V. Sharp
Publikováno v: Nucleic acids research. 22(13)
The La (SS-B) autoimmune antigen is an RNA-binding protein that is present in both nucleus and cytoplasm of eukaryotic cells. The spectrum of RNAs that interact with the La antigen includes species which also bind to the interferon-inducible protein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf5aa79c2f57e44547bae05352689b0
https://pubmed.ncbi.nlm.nih.gov/7518914
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