Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Marion Blomenrohr"'
Autor:
Bas P. A. Kokke, C. Marco Timmers, Henri Johannes Spijker, Jan Schouten, Pascal Renart Verkerk, Wim H. A. Dokter, Ruud Coumans, Patrick G. Groothuis, Ruud Ubink, Patrick Henry Beusker, Miranda M. C. van der Lee, Gerry J. A. Ariaans, Marion Blomenrohr
Publikováno v:
Bioconjugate chemistry. 31(9)
Engineering cysteines at specific sites in antibodies to create well-defined ADCs for the treatment of cancer is a promising approach to increase the therapeutic index and helps to streamline the manufacturing process. Here, we report the development
Autor:
Kim Berentsen, Patrick G. Groothuis, Marion Blomenrohr, Ronald Christiaan Elgersma, Wim H. A. Dokter, Danielle Jacobs, Miranda van der Lee, Monique van der Vleuten, Ruud Coumans, Patrick Henry Beusker, Diels van den Dobbelsteen, Ruud Ubink
Publikováno v:
Cancer Research. 81:925-925
5T4 is an oncofetal antigen with low expression in healthy tissues which is frequently overexpressed in different tumor types. Despite its overexpression in various malignancies and its association with poor prognosis, there are currently no marketed
Autor:
Fred Dijcks, Inge Hermens, Desiree Damming, Myrthe Rouwette, Ruud Ubink, Ruud Coumans, Patrick G. Groothuis, Ellen Mattaar, Danielle Jacobs, Marion Blomenrohr, Aloys Sesink, Wim H. A. Dokter, Monique van der Vleuten, Miranda van der Lee
Publikováno v:
Cancer Research. 81:926-926
c-Met, the cell-surface receptor for HGF/SF which is widely overexpressed in various solid cancer types, is an attractive target for the development of antibody-based therapeutics. However, the apparently delicate balance between anti-tumor activity