Výsledky vyhledávání - "Marion Blomenröhr"

Kisspeptin Signaling Is Indispensable for Neurokinin B, but not Glutamate, Stimulation of Gonadotropin Secretion in Mice

Autor: Antonio Romero-Ruiz, Maria Manfredi-Lozano, Manuel Tena-Sempere, David Garcia-Galiano, Magda A. M. Krajnc-Franken, Leonor Pinilla, Paula I. van Noort, Dorette van Ingen Schenau, Víctor M. Navarro, Francisco Gaytan, Silvia Leon, Marion Blomenröhr

Publikováno v: Endocrinology

Kisspeptins (Kp), products of the Kiss1 gene that act via Gpr54 to potently stimulate GnRH secretion, operate as mediators of other regulatory signals of the gonadotropic axis. Mouse models of Gpr54 and/or Kiss1 inactivation have been used to address

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9d6866618cfbfdb29c101f1eb3277f
https://doi.org/10.1210/en.2011-1260

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Cryopreserved cells facilitate cell-based drug discovery

Autor: Jeroen A.D.M. de Roos, Chris J. van Koppen, Marion Blomenröhr, Guido J.R. Zaman, Julia Oosterom

Publikováno v: Drug Discovery Today. 12:521-526

Advances in detection technologies have enabled an increased use of cell-based functional assays in early drug discovery, in particular for G protein-coupled receptors. Screening assays that use live cells are less prone to generate false positives t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c2cd6527d942f35377ad85143d08b8
https://doi.org/10.1016/j.drudis.2007.05.008

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Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse

Autor: Juan Carlos Roa, Marcel van Duin, Marion Blomenröhr, Francisco Ruiz-Pino, Francisco Gaytan, Alexia Barroso, Manuel Tena-Sempere, Silvia Leon, María J. Vázquez, Maria Manfredi-Lozano, Leonor Pinilla, David Garcia-Galiano, Antonio Romero-Ruiz

Publikováno v: Endocrinology. 155(8)

RF-amide-related peptide-3 (RFRP-3), the mammalian ortholog of the avian gonadotropin-inhibiting hormone (GnIH), operates via the NPFF1 receptor (NPFF1R) to repress the reproductive axis, therefore acting as counterpart of the excitatory RF-amide pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035fcad2d28cc884200c87fe3fbb456c
https://pubmed.ncbi.nlm.nih.gov/24823392

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Discrepancy Between Molecular Structure and Ligand Selectivity of a Testicular Follicle-Stimulating Hormone Receptor of the African Catfish (Clarias gariepinus)1

Autor: H. H. A. G. M. Van Der Putten, Cornelis P. Tensen, Jan Bogerd, Henry F. Vischer, Marion Blomenröhr, Joke C.M. Granneman, H.J.Th. Goos, Rüdiger W. Schulz, Coby Janssen-Dommerholt, Eva Andersson

Publikováno v: Biology of Reproduction. 64:1633-1643

A putative FSH receptor (FSH-R) cDNA was cloned from African catfish testis. Alignment of the deduced amino acid sequence with other (putative) glycoprotein hormone receptors and analysis of the African catfish gene indicated that the cloned receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cafd86ccbd50e904ef68aca51ff3b1e
https://doi.org/10.1095/biolreprod64.6.1633

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Lack of a C-terminal Tail in the Mammalian Gonadotropin-releasing Hormone Receptor Confers Resistance to Agonist-dependent Phosphorylation and Rapid Desensitization

Autor: Karin A. Eidne, Stefan R. Nahorski, Anders Heding, Milka Vrecl, Gary B. Willars, Marion Blomenröhr, Robin Sellar

Publikováno v: Journal of Biological Chemistry. 274:30146-30153

The mammalian gonadotropin-releasing hormone receptor (GnRH-R) is, at present, the only G-protein-coupled receptor that activates phospholipase C and lacks a C-terminal tail. We have previously demonstrated that this unique structural feature is asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bcb1a2d622d68478e524b8d08d518d
https://doi.org/10.1074/jbc.274.42.30146

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Pivotal role for the Cytoplasmic Carboxyl-Terminal Tail of a Nonmammalian Gonadotropin-Releasing Hormone Receptor in Cell Surface Expression, Ligand Binding, and Receptor Phosphorylation and Internalization

Autor: Karin A. Eidne, Robin Sellar, Rob Leurs, Anders Heding, Gary B. Willars, Jan Bogerd, Marion Blomenröhr

Publikováno v: Blomenröhr, M, Heding, A, Sellar, R, Leurs, R, Bogerd, J, Eidne, K A & Willars, G B 1999, ' Pivotal role for the Cytoplasmic Carboxyl-Terminal Tail of a Nonmammalian Gonadotropin-Releasing Hormone Receptor in Cell Surface Expression, Ligand Binding, and Receptor Phosphorylation and Internalization. ', Molecular Pharmacology, vol. 56, pp. 1229-1237 .
Molecular Pharmacology, 56, 1229-1237. American Society for Pharmacology and Experimental Therapeutics

The gonadotropin-releasing hormone receptor (GnRH-R) of the African catfish couples to phospholipase C and belongs to the large family of G protein-coupled receptors. We recently demonstrated that removal of the carboxyl-terminal tail (S331-Q379) fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42db57768fc2a5e1f940fea7b92bed0
https://hdl.handle.net/1871.1/c5cb44f1-6964-4da4-b132-cce4ad08d636

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