Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Marion B. Sewer"'
Autor:
Kai Cai, Marion B. Sewer
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 8, Pp 2121-2132 (2013)
Diacylglycerol kinase (DGK)θ is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid (PA). We have previously shown that PA is a ligand for the nuclear receptor steroidogenic factor 1 (SF1) and that cAMP-stimulated expression
Externí odkaz:
https://doaj.org/article/08c31bb8824d45038f7ccf04d4a18b12
Autor:
Donghui Li, Marion B. Sewer
Publikováno v:
Molecular and Cellular Endocrinology. 371:79-86
The production of glucocorticoids and aldosterone in the adrenal cortex is regulated at multiple levels. Biosynthesis of these hormones is initiated when cholesterol, the substrate, enters the inner mitochondrial membrane for conversion to pregnenolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3084281d37672415e661823ec9ae390
https://doi.org/10.1016/j.mce.2012.11.014
https://doi.org/10.1016/j.mce.2012.11.014
Publikováno v:
Molecular Biology of the Cell
DIAPH1, the RhoA effector protein, forms a complex in adrenocortical cells and is phosphorylated by a cAMP/PKA-dependent pathway. Phosphorylation differentially modulates protein–protein interactions, regulates the stability of the protein, and fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8b7b7c14f0c3e4e98b67ac01867a4a
https://doi.org/10.1091/mbc.e12-08-0597
https://doi.org/10.1091/mbc.e12-08-0597
Autor:
Natasha C. Lucki, Marion B. Sewer
Publikováno v:
Annual Review of Physiology. 74:131-151
Nuclear lipid metabolism is implicated in various processes, including transcription, splicing, and DNA repair. Sphingolipids play roles in numerous cellular functions, and an emerging body of literature has identified roles for these lipid mediators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a141a3535f800c50a3ca012ba5d668f6
https://doi.org/10.1146/annurev-physiol-020911-153321
https://doi.org/10.1146/annurev-physiol-020911-153321
Autor:
Natasha C. Lucki, Marion B. Sewer
Publikováno v:
Steroids. 75:390-399
Steroid hormones regulate various physiological processes including development, reproduction, and metabolism. These regulatory molecules are synthesized from cholesterol in endocrine organs - such as the adrenal glands and gonads - via a multi-step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c294c0949315a8f4b4496b3d12a8cf7c
https://doi.org/10.1016/j.steroids.2010.01.020
https://doi.org/10.1016/j.steroids.2010.01.020
Autor:
Marion B. Sewer, Natasha C. Lucki
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1791:706-713
Acid ceramidase (encoded by ASAH1) is a lipid hydrolase that catalyzes the conversion of ceramide (cer) into sphingosine (SPH) and a free fatty acid. Adrenocortical steroidogenesis is regulated by the trophic peptide hormone adrenocorticotropin (ACTH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5eda66fdc23e5e11ff391b6ccbdcf40
https://doi.org/10.1016/j.bbalip.2009.03.005
https://doi.org/10.1016/j.bbalip.2009.03.005
Publikováno v:
Molecular and Cellular Endocrinology. 283:104-113
In this study, we examined the role of sphingosine-1-phosphate (S1P) in regulating the transcription of the liver receptor homologue-1 (LRH-1) in breast cancer cells. We show that S1P induces LRH-1 mRNA expression in MCF-7 cells in a prostaglandin E2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aea4881ca23c65ec01b9ffb7ba08e6c
https://doi.org/10.1016/j.mce.2007.11.030
https://doi.org/10.1016/j.mce.2007.11.030
Publikováno v:
Molecular Endocrinology. 21:415-438
Transcription of the cytochrome P450 17 (CYP17) gene is regulated by cAMP-dependent binding of steroidogenic factor-1 (SF-1) to its promoter in the adrenal cortex. Using temporal chromatin immunoprecipitation and mammalian two-hybrid experiments, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43dbd77e60ac16b0fcdd31319994deb
https://doi.org/10.1210/me.2006-0361
https://doi.org/10.1210/me.2006-0361
Publikováno v:
Drug Metabolism Reviews. 39:371-388
By serving as ligands for nuclear and plasma membrane receptors, steroid hormones are key regulators of a diverse array of physiological processes. These hormones are synthesized from cholesterol in tissues such as the adrenal cortex, ovaries, testes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7872401b1337a5f072710dcfe65e4d
https://doi.org/10.1080/03602530701498828
https://doi.org/10.1080/03602530701498828
Publikováno v:
Molecular and cellular endocrinology. 427
Oxysterol binding protein-related protein 2 (ORP2) is a lipid binding protein that has been implicated in various cellular processes, including lipid sensing, cholesterol efflux, and endocytosis. We recently identified ORP2 as a member of a protein c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a777f0333c298cee0a23aaffdf862d4f
https://pubmed.ncbi.nlm.nih.gov/26992564
https://pubmed.ncbi.nlm.nih.gov/26992564