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Autor:
Elisabeth A. Bone, Marion Askew, Alison J. Thompson, Alan H. Davidson, Mark Whittaker, Lydia Saroglou, Drummond Alan Hastings, Andrew D. Miller, Rachael E. Coates, Sonja E. van Dijk, Fionna M. Martin, Paul Beckett, Claire L. Bellamy, Philip Huxley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:193-198
Peptidomimetic carboxylate- and hydroxamate-based inhibitors of matrix metalloproteinases containing extended P1′ groups have been prepared. Potent inhibition and good selectivity for MMP-2 has been observed for the compounds produced.