A Role for the V0 Sector of the V-ATPase in Neuroexocytosis: Exogenous V0d Blocks Complexin and SNARE Interactions with V0c

Autor: Christian Lévêque, Yves Maulet, Qili Wang, Marion Rame, Léa Rodriguez, Sumiko Mochida, Marion Sangiardi, Fahamoe Youssouf, Cécile Iborra, Michael Seagar, Nicolas Vitale, Oussama El Far

Publikováno v: Cells, Vol 12, Iss 5, p 750 (2023)

V-ATPase is an important factor in synaptic vesicle acidification and is implicated in synaptic transmission. Rotation in the extra-membranous V1 sector drives proton transfer through the membrane-embedded multi-subunit V0 sector of the V-ATPase. Int

Externí odkaz: https://doaj.org/article/59f893d975e14efca870c5732bb32957

The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions

Autor: Fabienne Mauxion, Jérôme Basquin, Sevim Ozgur, Marion Rame, Jana Albrecht, Ingmar Schäfer, Bertrand Séraphin, Elena Conti

Publikováno v: Cell Reports

The evolutionary conserved CCR4-NOT complex functions in the cytoplasm as the main mRNA deadenylase in both constitutive mRNA turnover and regulated mRNA decay pathways. The versatility of this complex is underpinned by its modular multi-subunit orga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b9b449b729a4d93de7480157dd5fe4
https://pubmed.ncbi.nlm.nih.gov/36586408

Dysfunction of calcium-regulated exocytosis at a single-cell level causes catecholamine hypersecretion in patients with pheochromocytoma

Autor: Sébastien Houy, Laura Streit, Inès Drissa, Marion Rame, Charles Decraene, Sophie Moog, Laurent Brunaud, Joël Lanoix, Rabie Chelbi, Florence Bihain, Stéphanie Lacomme, Sandra Lomazzi, Philippe Campoli, Michel Vix, Didier Mutter, Eustache Paramithiotis, Christophe Dubessy, Nicolas Vitale, Stéphane Ory, Stéphane Gasman

Publikováno v: Cancer letters. 543

Neuroendocrine tumors constitute a heterogeneous group of tumors arising from hormone-secreting cells and are generally associated with a dysfunction of secretion. Pheochromocytoma (Pheo) is a neuroendocrine tumor that develops from chromaffin cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af15117b0cb61f101a1e21487e7d4f91
https://pubmed.ncbi.nlm.nih.gov/35680072

Somatostatin analogue pasireotide (SOM230) inhibits catecholamine secretion in human pheochromocytoma cells

Autor: Laura Streit, Didier Mutter, Sylvain Hugel, Sophie Moog, Stéphanie Lacomme, Virginie Andry, Claire Nomine-Criqui, Nicolas Vitale, Marion Rame, Michel Vix, Herbert A. Schmid, Stéphane Ory, Stéphane Gasman, Emeline Tanguy, Yannick Goumon, Laurent Brunaud, Florence Bihain, Sandra Lomazzi

Publikováno v: Cancer Letters
Cancer Letters, Elsevier, 2021, ⟨10.1016/j.canlet.2021.10.009⟩

International audience; Increasingly common, neuroendocrine tumors (NETs) are regarded nowadays as neoplasms potentially causing debilitating symptoms and life-threatening medical conditions. Pheochromocytoma is a NET that develops from chromaffin ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c27f013e0d2933b61bbbc888282398d
https://hal.archives-ouvertes.fr/hal-03389020/file/1-s2.0-S030438352100519X-main.pdf

18F-FDOPA PET/CT Uptake Parameters Correlate with Catecholamine Secretion in Human Pheochromocytomas

Autor: Sophie Moog, Georges Weryha, Stéphane Ory, Stéphane Gasman, Elodie Chevalier, Laurent Brunaud, Marc Klein, Sébastien Houy, Marion Rame, Thomas Cuny

Publikováno v: Neuroendocrinology
Neuroendocrinology, Karger, 2018, 107 (3), pp.228-236. ⟨10.1159/000491578⟩
Neuroendocrinology, 2018, 107 (3), pp.228-236. ⟨10.1159/000491578⟩

Background: 18F-FDOPA positron emission tomography/computed tomography (PET/CT) is a sensitive nuclear imaging technology for the diagnosis of pheochromocytomas (PHEO). However, its utility in determining predictive factors for the secretion of catec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e343d1b1c3359e4f05262fce96c61f29
https://hal.archives-ouvertes.fr/hal-02323272