Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Marion, Flipo"'
Autor:
Coline Plé, Heng-Keat Tam, Anais Vieira Da Cruz, Nina Compagne, Juan-Carlos Jiménez-Castellanos, Reinke T. Müller, Elizabeth Pradel, Wuen Ee Foong, Giuliano Malloci, Alexia Ballée, Moritz A. Kirchner, Parisa Moshfegh, Adrien Herledan, Andrea Herrmann, Benoit Deprez, Nicolas Willand, Attilio Vittorio Vargiu, Klaas M. Pos, Marion Flipo, Ruben C. Hartkoorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, the authors identify pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through allosteric inhibition of it
Externí odkaz:
https://doaj.org/article/2d5e83c99b5c4265bf969d47fed84ba5
Autor:
Salia Tangara, Léo Faïon, Catherine Piveteau, Frédéric Capet, Romain Godelier, Marion Michel, Marion Flipo, Benoit Deprez, Nicolas Willand, Baptiste Villemagne
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 413 (2023)
The concept of privileged structure has been used as a fruitful approach for the discovery of novel biologically active molecules. A privileged structure is defined as a semi-rigid scaffold able to display substituents in multiple spatial directions
Externí odkaz:
https://doaj.org/article/457540ee79dc4ef9b38bd6f202d0cd9c
Autor:
Léo Faïon, Kamel Djaout, Catalin Pintiala, Catherine Piveteau, Florence Leroux, Alexandre Biela, Stéphanie Slupek, Rudy Antoine, Monika Záhorszká, Francois-Xavier Cantrelle, Xavier Hanoulle, Jana Korduláková, Benoit Deprez, Nicolas Willand, Alain R. Baulard, Marion Flipo
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 335 (2023)
Mycobacterium tuberculosis, the pathogen that causes tuberculosis, is responsible for the death of 1.5 million people each year and the number of bacteria resistant to the standard regimen is constantly increasing. This highlights the need to discove
Externí odkaz:
https://doaj.org/article/8f8af7ff2c8049dca93bfab59dd0da06
Autor:
Nina Compagne, Anais Vieira Da Cruz, Reinke T. Müller, Ruben C. Hartkoorn, Marion Flipo, Klaas M. Pos
Publikováno v:
Antibiotics, Vol 12, Iss 1, p 180 (2023)
Antimicrobial resistance (AMR) has become a major problem in public health leading to an estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and repeated use of antibiotics has led to bacterial strains that are partial
Externí odkaz:
https://doaj.org/article/c36548178e0f4e1bb0879082e17f1a6c
Autor:
Kevin Antraygues, Nina Compagne, Francesca Ruggieri, Kamel Djaout, Zainab Edoo, Maxime Eveque, Léo Faïon, Bruna Gioia, Salia Tangara, Anais Vieira Da Cruz, Baptiste Villemagne, Marion Flipo, Alain Baulard, Nicolas Willand
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 388 (2022)
The restrictions posed by the COVID-19 pandemic obliged the French Society for Medicinal Chemistry (Société de chimie thérapeutique) and the French Microbiology Society (Société Française de Microbiologie) to organize their joint autumn symposi
Externí odkaz:
https://doaj.org/article/f47136f0cbd64212844c0704ce3808b7
Autor:
Sushovan Dam, Salia Tangara, Claire Hamela, Theo Hattabi, Léo Faïon, Paul Carre, Rudy Antoine, Adrien Herledan, Florence Leroux, Catherine Piveteau, Maxime Eveque, Marion Flipo, Benoit Deprez, Laurent Kremer, Nicolas Willand, Baptiste Villemagne, Ruben C. Hartkoorn
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16651-16664. ⟨10.1021/acs.jmedchem.2c01493⟩
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16651-16664. ⟨10.1021/acs.jmedchem.2c01493⟩
International audience; It is critical that novel classes of antituberculosis drugs are developed to combat the increasing burden of infections by multidrug-resistant strains. To identify such a novel class of antibiotics, a chemical library of uniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a644599ffe66ea073b6bc501b605bcac
https://doi.org/10.1021/acs.jmedchem.2c01493
https://doi.org/10.1021/acs.jmedchem.2c01493
Autor:
Francesca Ruggieri, Nina Compagne, Kevin Antraygues, Maxime Eveque, Marion Flipo, Nicolas Willand
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2023, 256, pp.115413. ⟨10.1016/j.ejmech.2023.115413⟩
European Journal of Medicinal Chemistry, 2023, 256, pp.115413. ⟨10.1016/j.ejmech.2023.115413⟩
International audience; Antimicrobial resistance (AMR) is a major public health issue, causing 5 million deaths per year. Without any action plan, AMR will be in a near future the leading cause of death ahead of cancer. AMR comes from the ability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6701d9007286f34c49758179096ee3b7
https://hal.science/hal-04093378
https://hal.science/hal-04093378
Autor:
Benoit Deprez, Damien Bosc, Julie Charton, Cyril Couturier, Rebecca Deprez-Poulain, Marion Flipo, Florence Leroux, Baptiste Villemagne, Nicolas Willand
Publikováno v:
Molecules, Vol 26, Iss 19, p 6083 (2021)
Chemical biology and drug discovery are two scientific activities that pursue different goals but complement each other. The former is an interventional science that aims at understanding living systems through the modulation of its molecular compone
Externí odkaz:
https://doaj.org/article/3139cdf061794c5db887520979edb00b
Autor:
Joana Costa-Gouveia, Elisabetta Pancani, Samuel Jouny, Arnaud Machelart, Vincent Delorme, Giuseppina Salzano, Raffaella Iantomasi, Catherine Piveteau, Christophe J. Queval, Ok-Ryul Song, Marion Flipo, Benoit Deprez, Jean-Paul Saint-André, José Hureaux, Laleh Majlessi, Nicolas Willand, Alain Baulard, Priscille Brodin, Ruxandra Gref
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Tuberculosis (TB) is a leading infectious cause of death worldwide. The use of ethionamide (ETH), a main second line anti-TB drug, is hampered by its severe side effects. Recently discovered “booster” molecules strongly increase the ETH
Externí odkaz:
https://doaj.org/article/b72ffe20c51947b68f1019be57e2cb02
Autor:
Marion Flipo, Rosangela Frita, Marilyne Bourotte, María S. Martínez-Martínez, Markus Boesche, Gary W. Boyle, Geo Derimanov, Gerard Drewes, Pablo Gamallo, Sonja Ghidelli-Disse, Stephanie Gresham, Elena Jiménez, Jaime de Mercado, Esther Pérez-Herrán, Esther Porras-De Francisco, Joaquín Rullas, Patricia Casado, Florence Leroux, Catherine Piveteau, Mehdi Kiass, Vanessa Mathys, Karine Soetaert, Véronique Megalizzi, Abdalkarim Tanina, René Wintjens, Rudy Antoine, Priscille Brodin, Vincent Delorme, Martin Moune, Kamel Djaout, Stéphanie Slupek, Christian Kemmer, Marc Gitzinger, Lluis Ballell, Alfonso Mendoza-Losana, Sergio Lociuro, Benoit Deprez, David Barros-Aguirre, Modesto J. Remuiñán, Nicolas Willand, Alain R. Baulard
Publikováno v:
Science Translational Medicine. 14
The sensitivity of Mycobacterium tuberculosis , the pathogen that causes tuberculosis (TB), to antibiotic prodrugs is dependent on the efficacy of the activation process that transforms the prodrugs into their active antibacterial moieties. Various o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceee95809e2bca056e0d0c0c3d88cddd
https://doi.org/10.1126/scitranslmed.aaz6280
https://doi.org/10.1126/scitranslmed.aaz6280