Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mariola Piestrzeniewicz"'
Publikováno v:
Endocrine Regulations. :23-28
OBJECTIVE: In our earlier study we have demonstrated that MCF-7 cell line expresses all three opioid receptor types, micro, delta and kappa (MOR, DOR and KOR, respectively), but predominantly MOR. Morphine, as well as endogenous MOR-selective agonist
Autor:
Ewa Ciesielska, Elzbieta Pastwa, Leszek Szmigiero, Marek Gniazdowski, Mariola Piestrzeniewicz, William A. Denny
Publikováno v:
Biochemical Pharmacology. 56:351-359
An antitumor drug N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and its three close structural analogs N-[2-(hydroxyethylamino)ethyl]acridine-4-carboxamide (DACAH), N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide (amino-DACA), and
Publikováno v:
Acta Biochimica Polonica. 45:127-132
9-Aminoacridine carboxamide derivatives studied here form with DNA intercalative complexes which differ in the kinetics of dissociation. Inhibition of total RNA synthesis catalyzed by phage T7 and Escherichia coli DNA-dependent RNA polymerases correl
Publikováno v:
FEBS Journal. 273:1-3
Autor:
Katarzyna Gach, Anna Janecka, Mariola Piestrzeniewicz, Janusz Szemraj, Jakub Fichna, Dick Delbro
Publikováno v:
Chemical biologydrug design. 74(4)
Urokinase plasminogen activator plays a key role in tumor-associated processes, increasing cancer cell invasion and metastasis, and is therefore used as a marker in cancer prognosis. In this study, we have determined the effect of mu-opioid receptor
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 32(4)
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH(2)) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH(2)) are two recently isolated mu-opioid selective peptides with a potent antinociceptive activity, involved in a number of physiological processes, including food intake, vas
Autor:
Mariola Piestrzeniewicz, Anna Janecka, Jozef Vanden Broeck, Emmanuel Burgeon, Jakub Fichna, Jeroen Poels, Katarzyna Gach
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 317(3)
A functional assay, based on aequorin-derived luminescence triggered by receptor-mediated changes in intracellular calcium levels, was used to examine relative potency and efficacy of the mu-opioid agonists endomorphin-1, endomorphin-2, morphiceptin,
Autor:
Anna Janecka, Katarzyna Gach, Mariola Piestrzeniewicz, Jozef Vanden Broeck, Emmanuel Burgeon, Jeroen Poels, Jakub Fichna
Publikováno v:
Life sciences. 79(11)
A functional assay, based on aequorin-derived luminescence triggered by receptor-mediated changes in Ca 2+ levels, was used to examine relative potency and efficacy of the μ-opioid receptor antagonists. A series of position 3- and 4-substituted endo
Interactions of novel morpholine and hexamethylene derivatives of anthracycline antibiotics with DNA
Autor:
Janusz Szemraj, Marek Gniazdowski, Mariola Piestrzeniewicz, Dorota Wilmańska, Kazimierz Studzian
Publikováno v:
Zeitschrift fur Naturforschung. C, Journal of biosciences. 59(9-10)
Doxorubicin (DOX), daunorubicin (DRB), epidoxorubicin (EDOX) and their analogues with a 3′-NH2 group in daunosamine form a covalent bond with a 2-NH2 group of guanine via a methylene group from formaldehyde (CH2O). It is assumed that a Schiff base
Publikováno v:
Acta biochimica Polonica. 40(1)