Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mariola Napiórkowska"'
Autor:
Mariola Napiórkowska, Pratheeba Kumaravel, Mithulya Amboo Mahentheran, Ewelina Kiernozek-Kalińska, Emilia Grosicka-Maciąg
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 1999 (2024)
A set of nine derivatives, including five brominated compounds, was synthesized and the structures of these novel compounds were confirmed using 1H and 13C NMR as well as ESI MS spectra. These compounds were tested on four different cancer cell lines
Externí odkaz:
https://doaj.org/article/b799911750004e699a0ab54134a552c1
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7123 (2022)
In this work, the investigation of type and inhibitory strength of catalase by two pairs of aminoalkanol derivatives (1,7 diEthyl- and 1,7-diMethyl-8,9-diphenyl-4-azatricyclo (5.2.1.02.6) dec-8-ene- 3,5,10-trione) has been presented. The obtained res
Externí odkaz:
https://doaj.org/article/adb78e4796be4a2d990e414bb7f79560
Autor:
Jaime R. Cabrera-Pardo, Jorge Fuentealba, Javiera Gavilán, Daniel Cajas, José Becerra, Mariola Napiórkowska
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disorder that slowly destroys memory. The precise mechanism of AD is still not entirely understood and remains under discussion; it is believed to be a multifactorial dis
Externí odkaz:
https://doaj.org/article/5e057d0f9123405dab9f92cf16fcd2a7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 270 (2021)
Two aminoalkanol derivatives of 1,7-diEthyl-8,9-diphenyl-4azatricyclo (5.2.1.02.6) dec-8-ene-3,5,10-trione and two derivatives of 1,7-diMethyl-8,9-diphenyl-4-azatricyclo (5.2.1.02.6) dec-8-ene-3,5,10-trione were evaluated in vitro for their inhibitio
Externí odkaz:
https://doaj.org/article/9363475762e94894b73041bde9fc77c5
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11761 (2021)
Background: Acid phosphatase and its regulation are important objects of biological and clinical research and play an important role in the development and treatment of prostate and bone diseases. The newly patented aminoalkanol (4-[2-hydroxy-3-(prop
Externí odkaz:
https://doaj.org/article/970d311e8827494d8d4a1046d3c958f7
Autor:
Marcin Cieślak, Mariola Napiórkowska, Julia Kaźmierczak-Barańska, Karolina Królewska-Golińska, Anna Hawrył, Iwona Wybrańska, Barbara Nawrot
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4318 (2021)
Based on previously identified dicarboximides with significant anticancer and immunomodulatory activities, a series of 26 new derivatives were designed and synthesized by the Diels–Alder reaction between appropriate diene and maleimide or hydroxyma
Externí odkaz:
https://doaj.org/article/1d7532d8de3d4321ad554ee1388a9d5e
Autor:
Błażej Grodner, Mariola Napiórkowska
Publikováno v:
Molecules, Vol 26, Iss 4, p 993 (2021)
In this study, a complex consisting of 2-hydroxypropyl-β-cyclodextrin and 5,10,15,20-tetrakis (4-hydroxyphenyl) porphyrin, (named dual chiral-achiral selector complex) was used for the determination of two novel potential anticancer agents of (I) an
Externí odkaz:
https://doaj.org/article/91edf5fa61e34527947f9d0ff4d1117f
Autor:
Daniel Szulczyk, Anna Bielenica, Piotr Roszkowski, Michał A. Dobrowolski, Wioletta Olejarz, Mariola Napiórkowska, Marta Struga
Publikováno v:
Molecules, Vol 25, Iss 12, p 2816 (2020)
Seven novel derivatives of bis(2-aminoethyl)amine were synthesized. For compounds 1 and 7 single crystals were isolated and X-ray diffraction experiments were done. Lipophilicity and drug likeness were calculated in the initial stage of research. All
Externí odkaz:
https://doaj.org/article/4abedbf8bbf04d8d9998c98bb7e95482
Autor:
Marcin Cieślak, Julia Kaźmierczak-Barańska, Karolina Królewska-Golińska, Mariola Napiórkowska, Iga Stukan, Urszula Wojda, Barbara Nawrot
Publikováno v:
Biomolecules, Vol 9, Iss 9, p 446 (2019)
We identified novel dicarboximides that were selectively cytotoxic towards human leukemia cells. Using chemical and biological methods, we characterized the biological activity, identified cellular protein targets and defined the mechanism of action
Externí odkaz:
https://doaj.org/article/fbc68bbab05b4cfc9d48c259115ea71c
Autor:
Mariola Napiórkowska, Marcin Cieślak, Julia Kaźmierczak-Barańska, Karolina Królewska-Golińska, Barbara Nawrot
Publikováno v:
Molecules, Vol 24, Iss 8, p 1529 (2019)
The results of our previous research indicated that some derivatives of benzofurans, particularly halogeno-derivatives, are selectively toxic towards human leukemia cells. Continuing our work with this group of compounds we here report new data on th
Externí odkaz:
https://doaj.org/article/0f23eb1df3084dbea540081b273f67a3