Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Marioara F, Ciuculescu"'
Autor:
Erica B, Esrick, Leslie E, Lehmann, Alessandra, Biffi, Maureen, Achebe, Christian, Brendel, Marioara F, Ciuculescu, Heather, Daley, Brenda, MacKinnon, Emily, Morris, Amy, Federico, Daniela, Abriss, Kari, Boardman, Radia, Khelladi, Kit, Shaw, Helene, Negre, Olivier, Negre, Sarah, Nikiforow, Jerome, Ritz, Sung-Yun, Pai, Wendy B, London, Colleen, Dansereau, Matthew M, Heeney, Myriam, Armant, John P, Manis, David A, Williams
Publikováno v:
The New England journal of medicine. 384(3)
Sickle cell disease is characterized by hemolytic anemia, pain, and progressive organ damage. A high level of erythrocyte fetal hemoglobin (HbF) comprising α- and γ-globins may ameliorate these manifestations by mitigating sickle hemoglobin polymer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a54e613c2a9b45852cee621477397c3b
https://pubmed.ncbi.nlm.nih.gov/33471981
https://pubmed.ncbi.nlm.nih.gov/33471981
Autor:
Akihisa Mino, Christian Brendel, David A. Williams, Marioara F. Ciuculescu, Chad E. Harris, Alan B. Cantor, Anja Troeger
Publikováno v:
Small GTPases. 9:260-273
RhoH is a haematopoietic -specific, GTPase-deficient Rho GTPase that plays an essential role in T lymphocyte development and haematopoietic cell migration. RhoH is known to interact with ZAP70 in T cell receptor (TCR) signaling and antagonize Rac GTP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625c4ffc1459172b03dae29795bf0bf3
https://doi.org/10.1080/21541248.2016.1220780
https://doi.org/10.1080/21541248.2016.1220780
Autor:
David R. Williams, Olivier Negre, Erica B. Esrick, Sarah Nikiforow, Christian Brendel, Shanna Richard, Daniela Abriss, Jerome Ritz, Myriam Armant, Maureen Achebe, John P. Manis, Stephen Braunewell, Lauryn Christiansen, Matthew M. Heeney, Marioara F. Ciuculescu, Helene Negre, Heather Daley, Leslie Lehmann, Alessandra Biffi, Renee Maxwell, Stephanie Patriarca, Brenda Mackinnon, Colleen Dansereau
Publikováno v:
Blood. 132:1023-1023
Autologous gene therapy (GT) for beta-hemoglobinopathies has demonstrated encouraging early safety and efficacy using addition of a sickling-resistant globin gene to stem cells. Another therapeutic strategy for sickle cell disease (SCD) is erythroid-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da743e43882d46ca58e635b263536838
https://doi.org/10.1182/blood-2018-99-116733
https://doi.org/10.1182/blood-2018-99-116733
Autor:
Shin-Young Park, Leslie E. Silberstein, David A. Williams, Ronald Mathieu, Kimberly J. Canty, Marioara F. Ciuculescu
Publikováno v:
Blood. 125(20)
Hematopoietic stem cells (HSCs) are localized within specialized microenvironments throughout the BM. Nestin-expressing (Nestin(+)) mesenchymal stromal cells (MSCs) are important in the perivascular space. Rac is critical for MSC cell shape in vitro,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8b62e8cfd5755069b11e51e3dc1475
https://pubmed.ncbi.nlm.nih.gov/25824687
https://pubmed.ncbi.nlm.nih.gov/25824687
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1185
Genetic modification of cells using retroviral vectors is the method of choice when the cell population is difficult to transfect and/or requires persistent transgene expression in progeny cells. There are innumerable potential applications for these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4c87fcb302af416f89b1166fe6349a8
https://pubmed.ncbi.nlm.nih.gov/25062637
https://pubmed.ncbi.nlm.nih.gov/25062637
Publikováno v:
Methods in Molecular Biology ISBN: 9781493911325
Genetic modification of cells using retroviral vectors is the method of choice when the cell population is difficult to transfect and/or requires persistent transgene expression in progeny cells. There are innumerable potential applications for these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31507f9fcb3ddde49a15bce298956fe3
https://doi.org/10.1007/978-1-4939-1133-2_20
https://doi.org/10.1007/978-1-4939-1133-2_20
