Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mario Vieweger"'
Autor:
Sijin Guo, Mario Vieweger, Kaiming Zhang, Hongran Yin, Hongzhi Wang, Xin Li, Shanshan Li, Shuiying Hu, Alex Sparreboom, B. Mark Evers, Yizhou Dong, Wah Chiu, Peixuan Guo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Although paclitaxel is widely used as a chemotherapy, it suffers from poor solubility and toxicity issues. Here, the authors develop thermostable RNA nanoparticles and report the RNA-paclitaxel complex to display improved stability, drug loading capa
Externí odkaz:
https://doaj.org/article/db868a87fc9b4ea6a3135743c4926948
Publikováno v:
RNA Nanotechnology and Therapeutics ISBN: 9781003001560
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d13ad65dfcddf8968a94c9cfa6683fc0
https://doi.org/10.1201/9781003001560-22
https://doi.org/10.1201/9781003001560-22
Publikováno v:
Nanoscale
Chemical dendrimers have been shown to be a promising drug delivery platform due to their advantageous properties such as monodispersity, multivalency and branched structure. Taking advantage of self-assembly and its intrinsic negative charge, we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b748fb4aa7ba4d30182b978cd7d98c7d
https://doi.org/10.1039/d0nr02614j
https://doi.org/10.1039/d0nr02614j
Publikováno v:
ACS Nano
Rubber is a fascinating material in both industry and daily life. The development of elastomeric material in nanotechnology is imperative due to its economic and technological potential. By virtue of their distinctive physicochemical properties, nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572438f69c0e5228d9f477c910c86417
https://pubmed.ncbi.nlm.nih.gov/32902260
https://pubmed.ncbi.nlm.nih.gov/32902260
Autor:
Yizhou Dong, Wah Chiu, B. Mark Evers, Alex Sparreboom, Mario Vieweger, Shuiying Hu, Hongran Yin, Sijin Guo, Kaiming Zhang, Peixuan Guo, Xin Li, Hongzhi Wang, Shanshan Li
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Paclitaxel is widely used in cancer treatments, but poor water-solubility and toxicity raise serious concerns. Here we report an RNA four-way junction nanoparticle with ultra-thermodynamic stability to solubilize and load paclitaxel for targeted canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5e24aa274d01d4b1efc7f59357ce02
https://doi.org/10.1038/s41467-020-14780-5
https://doi.org/10.1038/s41467-020-14780-5
Autor:
Daniel W. Binzel, Jingyuan Li, Janice Ortega, Emil F. Khisamutdinov, Peixuan Guo, Mario Vieweger
Publikováno v:
ResearcherID
RNA nanotechnology is rapidly emerging. Due to advantageous pharmacokinetics and favorable in vivo biodistribution, RNA nanoparticles have shown promise in targeted delivery of therapeutics. RNA nanotechnology applies bottom-up assembly, thus elucida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba74261a65aef725e70fd9fe3a9e035d
https://doi.org/10.1261/rna.057646.116
https://doi.org/10.1261/rna.057646.116
Publikováno v:
Biophysical Journal. 109:2625-2636
Metabolite-dependent conformational switching in RNA riboswitches is now widely accepted as a critical regulatory mechanism for gene expression in bacterial systems. More recently, similar gene regulation mechanisms have been found to be important fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeaf19acc90125fae6767f2c9746b878
https://doi.org/10.1016/j.bpj.2015.10.006
https://doi.org/10.1016/j.bpj.2015.10.006
Autor:
Mario Vieweger, David J. Nesbitt
Structural RNA domains are widely involved in the regulation of biological functions, such as gene expression, gene modification, and gene repair. Activity of these dynamic regions depends sensitively on the global fold of the RNA, in particular, on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930b691a6a44034f9059549006f976fa
https://europepmc.org/articles/PMC5937115/
https://europepmc.org/articles/PMC5937115/
Publikováno v:
Expert Opinion on Drug Delivery. 13:23-36
Multidrug resistance and the appearance of incurable diseases inspire the quest for potent therapeutics.We review a new methodology in designing potent drugs by targeting multi-subunit homomeric biological motors, machines or complexes with Z1 and K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd14ae90c6691edd4316c20debb77018
https://doi.org/10.1517/17425247.2015.1082544
https://doi.org/10.1517/17425247.2015.1082544
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 276
RNA can serve as powerful building blocks for bottom-up fabrication of nanostructures for biotechnological and biomedical applications. In addition to current self-assembly strategies utilizing base pairing, motif piling and tertiary interactions, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247ccb89641040225fbac60960463f16
https://pubmed.ncbi.nlm.nih.gov/29454064
https://pubmed.ncbi.nlm.nih.gov/29454064