Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mario Tanguay"'
Publikováno v:
AAPS Open, Vol 4, Iss 1, Pp 1-6 (2018)
Abstract Fingolimod is an oral agent approved for the treatment of relapsing forms of multiple sclerosis (MS), which has demonstrated efficacy in Phase III trials in patients with relapsing-remitting MS (RRMS). The present study was designed to asses
Externí odkaz:
https://doaj.org/article/95f3551078a8484a957739a7f06216e7
Publikováno v:
Therapeutic Innovation & Regulatory Science. 54:128-138
A 505(b)(2) application is a type of US new drug application (NDA) that contains full reports of investigations of safety and effectiveness, but where at least some of the information required for approval comes from studies not conducted by or for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7ec8a52417423700ea4ca7021d14a7
https://doi.org/10.1007/s43441-019-00036-y
https://doi.org/10.1007/s43441-019-00036-y
Autor:
Robert M. Berman, Sonja Hartmann, Victoria Wirtz, Richard Larouche, Irfan Qureshi, Matt S. Anderson, Meghan Lovegren, Vlad Coric, Mario Tanguay
Publikováno v:
Clinical Pharmacology in Drug Development. 9:476-485
Orally administered riluzole extends survival in patients with amyotrophic lateral sclerosis, although it has significant shortcomings (eg, adverse events, dysphagic patients) that limit its utility. BHV-0223 is a Zydis-based orally disintegrating fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997c410413990e836b9a5e863c186db4
https://doi.org/10.1002/cpdd.747
https://doi.org/10.1002/cpdd.747
Publikováno v:
Clinical Pharmacology in Drug Development
A new formulation of levothyroxine sodium has been developed in the form of an oral solution contained in unit‐dose ampules. A study has been conducted to compare the bioavailability of levothyroxine sodium oral solution and levothyroxine sodium so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38ebb39b5ff021cd36a87d88e42063d
https://doi.org/10.1002/cpdd.608
https://doi.org/10.1002/cpdd.608
Publikováno v:
British Journal of Clinical Pharmacology. 83:1240-1251
Aims The aim of this paper is to investigate the role of drug concentration samplings in the modelling of the dose-response relationship. Methods Using an initial PK/PD model, a reference dataset was simulated. PK and PD samples were extracted to cre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::323ff191360009415661f1caea6b1707
https://doi.org/10.1111/bcp.13225
https://doi.org/10.1111/bcp.13225
Publikováno v:
AAPS Open, Vol 4, Iss 1, Pp 1-6 (2018)
Fingolimod is an oral agent approved for the treatment of relapsing forms of multiple sclerosis (MS), which has demonstrated efficacy in Phase III trials in patients with relapsing-remitting MS (RRMS). The present study was designed to assess bioequi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7e7fff48f11a7149b98cc498486a67
https://doi.org/10.1186/s41120-018-0023-3
https://doi.org/10.1186/s41120-018-0023-3
Modeling Testosterone Circadian Rhythm in Hypogonadal Males: Effect of Age and Circannual Variations
Autor:
Olivier Barrière, Mario Tanguay, Julie Desrochers, Fahima Nekka, Pierre-Olivier Tremblay, Mario González-Sales
Publikováno v:
The AAPS Journal
The objective of this study was to characterize the baseline circadian rhythm of testosterone levels in hypogonadal men. A total of 859 baseline profiles of testosterone from hypogonadal men were included in this analysis. The circadian rhythm of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335a4d192dba25f3da3da2b51bbf2155
http://europepmc.org/articles/PMC4706275
http://europepmc.org/articles/PMC4706275
Autor:
Vincent Pichette, Olivier Barrière, Pierre-Olivier Tremblay, Raphaël Vlavonou, Mario Tanguay, Eric Shink, Richard Larouche, Marc M. Perreault
Publikováno v:
The Journal of Clinical Pharmacology. 54:584-592
The pharmacokinetics of baclofen is well delineated in subjects with normal kidney function (KF); however, pharmacokinetics data in patients with chronic kidney disease (CKD) are not and dosage recommendations remain empirical. The effects of CKD on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccd785f3338878490c7b30cc3a153b3d
https://doi.org/10.1002/jcph.247
https://doi.org/10.1002/jcph.247
Autor:
Richard Larouche, François Vallée, Audrey Lainesse, Mario Tanguay, Augusto Filipe, Susana Almeida
Publikováno v:
Arzneimittelforschung. 54:757-762
An open-label, randomised, cross-over single dose study, using 2 periods x 2 sequences, with a minimum washout period of 21 days, was conducted in order to assess the comparative bioavailability of two formulations of terbinafine (CAS 78628-80-5) 250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12d0e545d830da8a560231aa61e1f4d0
https://doi.org/10.1055/s-0031-1297033
https://doi.org/10.1055/s-0031-1297033
Autor:
Benôıt Girard, Susana Almeida, Mario Tanguay, Augusto Filipe, Ana Almeida, Stéphanie Gagnon, Aitor Mirapeix
Publikováno v:
Arzneimittelforschung. 55:218-222
This study was conducted in order to assess the bioequivalence of two different coated tablet formulations containing 5 mg finasteride (CAS 98319-26-7). Twenty-six healthy volunteers were enrolled in an open, randomised, crossover single dose study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6f94db60fa8b86164eab10fd751110
https://doi.org/10.1055/s-0031-1296848
https://doi.org/10.1055/s-0031-1296848