Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Mario T. Philipp"'
Publikováno v:
Pathogens, Vol 12, Iss 1, p 132 (2023)
The blacklegged tick, Ixodes scapularis, is the predominant vector of Borrelia burgdorferi, the agent of Lyme disease in the USA. Natural hosts of I. scapularis such as Peromyscus leucopus are repeatedly infested by these ticks without acquiring tick
Externí odkaz:
https://doaj.org/article/fe9144a3b7884ad9b0f0463793697ee7
Autor:
Amanda R. Burmeister, M. Brittany Johnson, Vinita S. Chauhan, Megan J. Moerdyk-Schauwecker, Ada D. Young, Ian D. Cooley, Alejandra N. Martinez, Geeta Ramesh, Mario T. Philipp, Ian Marriott
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract Background The tachykinin substance P (SP) is recognized to exacerbate inflammation at peripheral sites via its target receptor, neurokinin 1 receptor (NK-1R), expressed by leukocytes. More recently, SP/NK-1R interactions have been associate
Externí odkaz:
https://doaj.org/article/96049e4fe6d543dd8914c0da8333e541
Autor:
Geetha Parthasarathy, Mario T. Philipp
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract Background In previous studies, human oligodendrocytes were demonstrated to undergo apoptosis in the presence of Borrelia burgdorferi under an inflammatory milieu. Subsequently, we determined that the MEK/ERK pathway played a significant rol
Externí odkaz:
https://doaj.org/article/63a69e0caada46238c0fea98073a2bef
Multi-platform Approach for Microbial Biomarker Identification Using Borrelia burgdorferi as a Model
Autor:
Kathryn J. Pflughoeft, Michael Mash, Nicole R. Hasenkampf, Mary B. Jacobs, Amanda C. Tardo, D. Mitchell Magee, Lusheng Song, Joshua LaBaer, Mario T. Philipp, Monica E. Embers, David P. AuCoin
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
The identification of microbial biomarkers is critical for the diagnosis of a disease early during infection. However, the identification of reliable biomarkers is often hampered by a low concentration of microbes or biomarkers within host fluids or
Externí odkaz:
https://doaj.org/article/4a4842e7774b4d27897bba84fc03c345
Publikováno v:
Mediators of Inflammation, Vol 2013 (2013)
Cytokines and chemokines are proteins that coordinate the immune response throughout the body. The dysregulation of cytokines and chemokines is a central feature in the development of neuroinflammation, neurodegeneration, and demyelination both in th
Externí odkaz:
https://doaj.org/article/c53777fb8aab4c56b104c13abd8767aa
Publikováno v:
Mediators of Inflammation, Vol 2013 (2013)
Externí odkaz:
https://doaj.org/article/82398e22d62e4b7681ee750acfa44f52
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
In this article we review the apoptotic mechanisms most frequently encountered in bacterial infections of the central nervous system (CNS). We focus specifically on apoptosis of neural cells (neurons and glia), and provide first an overview of the ph
Externí odkaz:
https://doaj.org/article/f0a9d01eb5434fbdb8910f13b3d2934e
Autor:
Monica E. Embers, Stephen W. Barthold, Juan T. Borda, Lisa Bowers, Lara Doyle, Emir Hodzic, Mary B. Jacobs, Nicole R. Hasenkampf, Dale S. Martin, Sukanya Narasimhan, Kathrine M. Phillippi-Falkenstein, Jeanette E. Purcell, Marion S. Ratterree, Mario T. Philipp
Publikováno v:
PLoS ONE, Vol 7, Iss 4 (2012)
Externí odkaz:
https://doaj.org/article/6fe2c3af0ca041d386656b487fde723b
Publikováno v:
Journal of Neurology and Neuromedicine. 1:29-36
This review addresses the role that substance P (SP) and its preferred receptor neurokinin-1 (NK1R) play in neuroinflammation associated with select bacterial, viral, parasitic, and neurodegenerative diseases of the central nervous system. The SP/NK1
Autor:
Vinita S. Chauhan, Alejandra N. Martinez, Ian D. Cooley, Mario T. Philipp, Ada D. Young, Geeta Ramesh, Ian Marriott, M. Brittany Johnson, Amanda R. Burmeister, Megan Moerdyk-Schauwecker
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-11 (2017)
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-11 (2017)
Background The tachykinin substance P (SP) is recognized to exacerbate inflammation at peripheral sites via its target receptor, neurokinin 1 receptor (NK-1R), expressed by leukocytes. More recently, SP/NK-1R interactions have been associated with se