Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Mario Schubert"'
Autor:
Stephan R. Künzel, Erik Klapproth, Nick Zimmermann, Susanne Kämmerer, Mario Schubert, Karolina Künzel, Maximilian Hoffmann, Stephan Drukewitz, Anne Vehlow, Jiri Eitler, Marieke Arriens, Jessica Thiel, Romy Kronstein-Wiedemann, Maximiliane Tietze, Stefan Beissert, Bertold Renner, Ali El-Armouche, Claudia Günther
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Radiation-induced morphea (RIM) is a rare complication of radiotherapy presenting as inflammatory fibrosis, most commonly reported in breast cancer patients. As underlying disease mechanisms are not well understood, targeted therapies are la
Externí odkaz:
https://doaj.org/article/ca14d9c2e1744a85acf698b849bb68f5
Autor:
Janos Wasternack, Hendrik V. Schröder, J. Felix Witte, Mihkel Ilisson, Henrik Hupatz, Julian F. Hille, Marius Gaedke, Arto M. Valkonen, Sebastian Sobottka, Alexander Krappe, Mario Schubert, Beate Paulus, Kari Rissanen, Biprajit Sarkar, Siegfried Eigler, Ute Resch-Genger, Christoph A. Schalley
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract In nature, molecular environments in proteins can sterically protect and stabilize reactive species such as organic radicals through non-covalent interactions. Here, we report a near-infrared fluorescent rotaxane in which the stabilization o
Externí odkaz:
https://doaj.org/article/232d32d3b189456694ae2f1096b1f121
Autor:
Juliane Hannemann, Katrin Wasser, Yoana Mileva, Fiona Kleinsang, Mario Schubert, Edzard Schwedhelm, Kaomei Guan, Rolf Wachter, Rainer Böger
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Background Atrial fibrillation (AF) is a stroke risk factor that often remains undetected at hospital admission. Long‐term Holter monitoring helps to identify patients with previously unrecognized AF. Asymmetric (ADMA) and symmetric dimethylarginin
Externí odkaz:
https://doaj.org/article/70f7f2dad8af4eb195e2aa580ffe32bb
Autor:
Arthur Hinterholzer, Jennifer Moises, Christof Regl, Sebastian Schwap, Erdmann Rapp, Christian G. Huber, Mario Schubert
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The α-Gal epitope consisting of the terminal trisaccharide Galα1,3Galβ1,4GlcNAc exposed on cell or protein surfaces can cause severe immune reactions, such as hypersensitivity reactions, in humans. This epitope is also called the xenotransplantati
Externí odkaz:
https://doaj.org/article/d2a62006075448058a90ce5647d9d10a
Autor:
Timm Fiebig, Johannes T. Cramer, Andrea Bethe, Petra Baruch, Ute Curth, Jana I. Führing, Falk F. R. Buettner, Ulrich Vogel, Mario Schubert, Roman Fedorov, Martina Mühlenhoff
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Neisseria meningitidis capsular polysaccharide (CPS) is a major virulence factor and vaccine formulations against Neisseria meningitidis serogroup A (NmA) contain O-acetylated CPS. Here, the authors provide mechanistic insights into CPS O-acetylation
Externí odkaz:
https://doaj.org/article/e72fba9673214d1d84ba89818eb3a079
Autor:
Christa Litschko, Insa Budde, Monika Berger, Andrea Bethe, Julia Schulze, E. Alberto Alcala Orozco, Reza Mahour, Peter Goettig, Jana Indra Führing, Thomas Rexer, Rita Gerardy-Schahn, Mario Schubert, Timm Fiebig
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Economic synthesis platforms for the production of animal vaccines could help reduce the overuse and misuse of antibiotics in animal husbandry, which contributes greatly to the increase of antibiotic resistance. Here, we describe a highly versatile,
Externí odkaz:
https://doaj.org/article/5722c046760342c281fde9f8456cbd10
Autor:
Wener Li, Michael Stauske, Xiaojing Luo, Stefan Wagner, Meike Vollrath, Carola S. Mehnert, Mario Schubert, Lukas Cyganek, Simin Chen, Sayed-Mohammad Hasheminasab, Gerald Wulf, Ali El-Armouche, Lars S. Maier, Gerd Hasenfuss, Kaomei Guan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Brugada syndrome (BrS) is one of the major causes of sudden cardiac death in young people, while the underlying mechanisms are not completely understood. Here, we investigated the pathophysiological phenotypes and mechanisms using induced pluripotent
Externí odkaz:
https://doaj.org/article/67390607ff314c6cac21aee37e21a20f
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Metabolic diseases and diabetes represent an increasing global challenge for human health care. As associated with a strongly elevated risk of developing atherosclerosis, kidney failure and death from myocardial infarction or stroke, the treatment of
Externí odkaz:
https://doaj.org/article/aa4fbc2612d84b18ac117e2bf7b9ba49
Autor:
Xiaojing Luo, Wener Li, Karolina Künzel, Sarah Henze, Lukas Cyganek, Anna Strano, Mareike S. Poetsch, Mario Schubert, Kaomei Guan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
In adult cardiomyocytes (CMs), the type 2 ryanodine receptor (RYR2) is an indispensable Ca2+ release channel that ensures the integrity of excitation-contraction coupling, which is fundamental for every heartbeat. However, the role and importance of
Externí odkaz:
https://doaj.org/article/f553e500221045f0aa217679c387b205
Autor:
Wener Li, Xiaojing Luo, Mareike S. Poetsch, Reinhard Oertel, Kapil Nichani, Martin Schneider, Anna Strano, Marcel Hasse, Robert-Patrick Steiner, Lukas Cyganek, Karina Hettwer, Steffen Uhlig, Kirsten Simon, Kaomei Guan, Mario Schubert
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 220 (2022)
Adverse effects of drug combinations and their underlying mechanisms are highly relevant for safety evaluation, but often not fully studied. Hydroxychloroquine (HCQ) and azithromycin (AZM) were used as a combination therapy in the treatment of COVID-
Externí odkaz:
https://doaj.org/article/b58f02bdcb5c4b80bfbe8c19116f2fa7