Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mario Sanches"'
Autor:
Nina E. Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O’Toole, Elizabeth Whalen, Peter W. Y. Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E. Atkinson, Jason Baardsnes, Liam J. Worrall, Duncan Browman, Emma E. Smith, Priya Baichoo, Chi Wing Cheng, Joy Guedia, Sohyeong Kang, Abhishek Mukhopadhyay, Lisa Newhook, Anders Ohrn, Prajwal Raghunatha, Matteo Zago-Schmitt, Joseph D. Schrag, Joel Smith, Patricia Zwierzchowski, Joshua M. Scurll, Vincent Fung, Sonia Black, Natalie C. J. Strynadka, Michael R. Gold, Leonard G. Presta, Gordon Ng, Surjit Dixit
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cyt
Externí odkaz:
https://doaj.org/article/8a871ad93e594eeba832492229b1329b
Autor:
Mario Sanches, Igor D’Angelo, Maria Jaramillo, Jason Baardsnes, John Zwaagstra, Joe Schrag, Ian Schoenhofen, Mauro Acchione, Sam Lawn, Grant Wickman, Nina Weisser, David K. Y. Poon, Gordon Ng, Surjit Dixit
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
As biologics have become a mainstay in the development of novel therapies, protein engineering tools to expand on their structural advantages, namely specificity, affinity, and valency are of interest. Antibodies have dominated this field as the pref
Externí odkaz:
https://doaj.org/article/a5ed50a220974d43b325471bef850d35
Autor:
Fabiano Tófoli de Araújo, Victor M Bolanos-Garcia, Cristiane T Pereira, Mario Sanches, Elisa E Oshiro, Rita C C Ferreira, Dimitri Y Chigardze, João Alexandre Gonçalves Barbosa, Luís Carlos de Souza Ferreira, Celso E Benedetti, Tom L Blundell, Andrea Balan
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80083 (2013)
BACKGROUND: The uptake of sulphur-containing compounds plays a pivotal role in the physiology of bacteria that live in aerobic soils where organosulfur compounds such as sulphonates and sulphate esters represent more than 95% of the available sulphur
Externí odkaz:
https://doaj.org/article/6fc4a2b0c5fc4ae0992738c42902d533
Autor:
Mario Sanches Matilde Junior
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
Um dos maiores problemas encontrados em terapias anti-retrovirais contra AIDS é a emergência de variantes virais que exibem resistência aos fármacos disponíveis e subtiposvirais naturalmente mais suscetíveis ao desenvolvimento de falha terapêu
Akademický článek
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Publikováno v:
Revista Bioética, Vol 32 (2024)
Resumo Este artigo apresenta uma análise crítica da obra de Tristram Engelhardt, com foco no princípio da permissão. Argumenta-se que, em contextos de intensas desigualdades sociais e negação de direitos, a aplicação da ética de procedimento
Externí odkaz:
https://doaj.org/article/3389aa3246c240588e425cc56af6c9c2
Autor:
Grant Wickman, Sam Lawn, Joe Schrag, Gordon Yiu Kon Ng, Nina E. Weisser, David Kai Yuen Poon, Mario Sanches, Maria L. Jaramillo, Jason Baardsnes, Mauro Acchione, Igor Edmondo Paolo D'angelo, John C. Zwaagstra, Ian Schoenhofen, Surjit Bhimarao Dixit
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
As biologics have become a mainstay in the development of novel therapies, protein engineering tools to expand on their structural advantages, namely specificity, affinity, and valency are of interest. Antibodies have dominated this field as the pref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9914dffa3f6bcd78d30b1982a9e2e0f
https://doi.org/10.1080/19420862.2020.1802188
https://doi.org/10.1080/19420862.2020.1802188
Publikováno v:
Tetsu-to-Hagane. 98:48-54
Slag as by-product of Cu making has been produced in large amounts in Chile, and around 5 million tons of slag are estimated to be disposed every year and 40 to 45 million tons have been accumulated. Typical Chilean Cu slag contains about 0.3 mass% M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f65907e940c77f839765d6f5c0049c3
https://doi.org/10.2355/tetsutohagane.98.48
https://doi.org/10.2355/tetsutohagane.98.48
Autor:
Anne-Claude Gingras, Lucien C.D. Gibson, Brett Larsen, Mario Sanches, Ian C. Scott, Stephen Tate, Laurence Pelletier, Frank Sicheri, Marilyn Goudreault, Derek F. Ceccarelli, George S. Baillie, W. Brent Derry, Michelle J. Kean
Publikováno v:
Journal of Biological Chemistry. 286:25065-25075
Cerebral cavernous malformations (CCMs) are alterations in brain capillary architecture that can result in neurological deficits, seizures, or stroke. We recently demonstrated that CCM3, a protein mutated in familial CCMs, resides predominantly withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc416fc02b8c1bbbda0628def262838e
https://doi.org/10.1074/jbc.m110.214486
https://doi.org/10.1074/jbc.m110.214486
Autor:
Michael Prakesch, Rima Al-awar, Kenneth Lee, Lynn Lehmann, Gennadiy Poda, Danka Vuga, David Chiovitti, Colleen Schweitzer, Marella D. Canny, Julie L. Lucas, John B. Patterson, Nero Thevakumaran, Andras Toro, Nicole M. Duffy, Qingping Zeng, Igor Kurinov, Daniel Durocher, David Uehling, Victor Tam, Brian J. Wilson, Manisha Talukdar, Mario Sanches, Frank Sicheri
Publikováno v:
Nature communications
Endoplasmic reticulum (ER) stress activates the unfolded protein response and its dysfunction is linked to multiple diseases. The stress transducer IRE1α is a transmembrane kinase endoribonuclease (RNase) that cleaves mRNA substrates to re-establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a763c3a28c964003e2743b791e1302b
https://pubmed.ncbi.nlm.nih.gov/25164867
https://pubmed.ncbi.nlm.nih.gov/25164867