N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis

Autor: Juciano Gasparotto, Alice Kunzler, Mario Roberto Senger, Celeste da Silva Freitas de Souza, Salvatore Giovanni de Simone, Rafael Calixto Bortolin, Nauana Somensi, Felipe Dal-Pizzol, José Claudio Fonseca Moreira, Ana Lúcia Abreu-Silva, Kátia da Silva Calabrese, Floriano Paes Silva Jr, Daniel Pens Gelain

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 112, Iss 2, Pp 146-154

BACKGROUND Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES To investigate oxidative stress and molecular in

Externí odkaz: https://doaj.org/article/453f2fb9b84e4675b832bb713927d0ce

Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease

Autor: Pedro Ozorio Brum, Flávio Gabriel Carazza Kessler, Alana Castro Panzenhagen, Hugo C. Castro-Faria-Neto, Marlene Campos Soares, Giuliana Viegas Schirato, Walter César Góes Valente, Bogar Omar Araújo Montoya, José Cláudio Fonseca Moreira, Patrícia A. Reis, Daniel Pens Gelain, Lin Kooi Ong, Floriano P. Silva, Juciano Gasparotto, Daniel Oppermann Peixoto, Felipe Dal-Pizzol, Mario Roberto Senger, Emilio Telles de Sá Moreira

Publikováno v: The Journal of Biological Chemistry

Schistosomiasis, a neglected tropical disease caused by trematodes of the Schistosoma genus, affects over 250 million people around the world. This disease has been associated with learning and memory deficits in children, whereas reduced attention l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf79d482bbf1969a5c99fa929529ec2
http://europepmc.org/articles/PMC8361297

Hypoglycaemic activity of Bauhinia holophylla through GSK3-β inhibition and glycogenesis activation

Autor: Anne Lígia Dokkedal, Natalia Moretti Violato, João M. Rezende-Neto, Floriano P. Silva-Junior, Mario Roberto Senger, Luiz Leonardo Saldanha, Aislan Quintiliano Delgado, Henrique J. N. Morgan, José Roberto Bosqueiro, Laís Goyos Pieroni, Nathalia Ap. De Paula Camaforte, Priscilla Maria Ponce Vareda

Publikováno v: Pharmaceutical Biology, Vol 57, Iss 1, Pp 269-279 (2019)
Pharmaceutical Biology
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2019-10-04T12:36:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Context: Bauhinia L. species, including Bauhinia holophylla (Bong.) Steud.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a910852709df17148176ecdc6c7f05af
https://doi.org/10.1080/13880209.2019.1599962

Synthesis of new lophine–carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling

Autor: Laurent E. Dardenne, Floriano Paes Silva-Jr, Diogo S. Lüdtke, Cristiane Martins Cardoso de Salles, Luana Silva, Marco Antonio Ceschi, Rafael Ferreira Dantas, Aline Rigon Zimmer, Gisele Barbosa, Thaís Carine Ruaro, Mario Roberto Senger, João Paulo Bizarro Lopes, Lídia Moreira Lima, Isabella A. Guedes

Publikováno v: Medchemcomm

In this study, we synthesized nine novel hybrids derived from d-xylose, d-ribose, and d-galactose sugars connected by a methylene chain with lophine. The compounds were synthesized by a four-component reaction to afford the substituted imidazole moie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6104681a2a618eb92853a64b80bb8b3c
https://europepmc.org/articles/PMC7451069/

Dealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings

Autor: Floriano P. Silva-Junior, Bruno J. Neves, Sabrina Baptista Ferreira, Mario Roberto Senger, Carolina Horta Andrade, Tereza Cristina Santos Evangelista, Rafael Ferreira Dantas

Introduction: The timely identification biologically active chemicals, in disease relevant screening assays, is a major endeavor in drug discovery. The existence of frequent hitters (FHs) in non-related assays poses a formidable challenge in terms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ea79b9087a87f77fd40bd4c227ec89