Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Mario R. Mautino"'
Autor:
Asha Nayak-Kapoor, Zhonglin Hao, Ramses Sadek, Robin Dobbins, Lisa Marshall, Nicholas N. Vahanian, W. Jay Ramsey, Eugene Kennedy, Mario R. Mautino, Charles J. Link, Ray S. Lin, Stephanie Royer-Joo, Xiaorong Liang, Laurent Salphati, Kari M. Morrissey, Sami Mahrus, Bruce McCall, Andrea Pirzkall, David H. Munn, John E. Janik, Samir N. Khleif
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-12 (2018)
Abstract Background Indoleamine-2,3-dioxygenase 1 (IDO1) catalyzes the oxidation of tryptophan into kynurenine and is partially responsible for acquired immune tolerance associated with cancer. The IDO1 small molecule inhibitor navoximod (GDC-0919, N
Externí odkaz:
https://doaj.org/article/fa3f41ad888d41f5a1c759f8b6fa21b2
Autor:
Nicholas N. Vahanian, Lucía M Mautino, Benjamin L. Turner, Clarissa Van Allen, James Adams, Mario R. Mautino, Erik L. Brincks, Lifu Wang, Charles J. Link, Agnieszka Marcinowicz, Sanjeev Kumar, Jiyuan Ke, Michael Essmann
Publikováno v:
Oncotarget
Indoximod has shaped our understanding of the biology of IDO1 in the control of immune responses, though its mechanism of action has been poorly understood. Previous studies demonstrated that indoximod creates a tryptophan (Trp) sufficiency signal th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5cce8b75b47251d0d6f4b5994a750f
https://doi.org/10.18632/oncotarget.27646
https://doi.org/10.18632/oncotarget.27646
Autor:
Wen Liu, Amy Gustafson, Firoz Jaipuri, Erica VanderPorten, Leanne Goon, Yamin Zhang, Guosheng Wu, Zuhui Zhang, Antonio G. DiPasquale, Xiaokai Li, Angela J. Oh, Lewis J. Gazzard, Seth F. Harris, Jesse Waldo, Roheeth Kumar Pavana, Yichin Liu, Venkata Velvadapu, Cheng Shao, Yuen Po-Wai, Mario R. Mautino, Zhonghua Pei, Hank La, Hima Potturi, Georgette Castanedo, Benjamin D. Sellers, Kevin DeMent, Sanjeev Kumar, Richard Pastor, Rohan Mendonca, Brendan T. Parr
Publikováno v:
ACS Med Chem Lett
[Image: see text] A class of imidazoisoindole (III) heme-binding indoleamine-2,3-dioxygenase (IDO1) inhibitors were optimized via structure-based drug design into a series of tryptophan-2,3-dioxygenase (TDO)-selective inhibitors. Kynurenine pathway m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701dd22f186bad66eefde1770830d8d6
https://doi.org/10.1021/acsmedchemlett.0c00004
https://doi.org/10.1021/acsmedchemlett.0c00004
Autor:
James Adams, Richard P. Metz, Angela J. Oh, Firoz Jaipuri, Mario R. Mautino, Agnieszka Marcinowicz, Clarissa Van Allen, Xiaoxia Zhang, Kesharwani Tanay, Jesse Waldo, Seth F. Harris, Sanjeev Kumar
Publikováno v:
Journal of Medicinal Chemistry. 62:6705-6733
A novel class of 5-substituted 5H-imidazo[5,1-a]isoindoles are described as potent inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1). A structure-based drug design approach was used to elaborate the 5H-imidazo[5,1-a]isoindole core and to improve pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56875c7c15f56666fae9647d4e37884f
https://doi.org/10.1021/acs.jmedchem.9b00662
https://doi.org/10.1021/acs.jmedchem.9b00662
Autor:
Sanjeev Kumar, Charles J. Link, Clarissa Van Allen, Firoz Jaipuri, Hima Potturi, Agnieszka Marcinowicz, Hong Zhuang, Jesse Waldo, Mario R. Mautino, James Adams, Erik L. Brincks, Nicholas N. Vahanian
Publikováno v:
European journal of medicinal chemistry. 198
A series of different prodrugs of indoximod, including estesrs and peptide amides were synthesized with the aim of improving its oral bioavailability in humans. The pharmacokinetics of prodrugs that were stable in buffers, plasma and simulated gastri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7ce0bb7c042623aab89d62e46b3bef
https://pubmed.ncbi.nlm.nih.gov/32422549
https://pubmed.ncbi.nlm.nih.gov/32422549
Autor:
Sanjeev, Kumar, Jesse P, Waldo, Firoz A, Jaipuri, Agnieszka, Marcinowicz, Clarissa, Van Allen, James, Adams, Tanay, Kesharwani, Xiaoxia, Zhang, Richard, Metz, Angela J, Oh, Seth F, Harris, Mario R, Mautino
Publikováno v:
Journal of medicinal chemistry. 62(14)
A novel class of 5-substituted 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41b14e03b0f0c50f4128353b3cb174d1
https://pubmed.ncbi.nlm.nih.gov/31264862
https://pubmed.ncbi.nlm.nih.gov/31264862
Autor:
David Noyes, Scott J. Antonia, Richard Lush, Anthony Neuger, Mario R. Mautino, Hatem Soliman, Hyo S. Han, Alberto Chiappori, John D. Roberts, Charles J. Link, Howard Streicher, Nicholas N. Vahanian, Fatema Khambati, Daniel M. Sullivan, Roohi Ismail-Khan, Susan Minton
Publikováno v:
Oncotarget
// hatem h. soliman 1 , susan e. minton 1 , hyo sook han 1 , roohi ismail-khan 1 , anthony neuger 1 , fatema khambati 1 , david noyes 1 , richard lush 1 , alberto a. chiappori 1 , john d. roberts 2 , charles link 3 , nicholas n. vahanian 3 , mario ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad73c6f42d75345e0f1f2e399cf3d39
https://doi.org/10.18632/oncotarget.8216
https://doi.org/10.18632/oncotarget.8216
Autor:
Mario R. Mautino, Ray S. Lin, John Edward Janik, Eugene P. Kennedy, Andrea Pirzkall, Charles J. Link, Xiaorong Liang, David H. Munn, Sami Mahrus, Bruce McCall, Nicholas N. Vahanian, Laurent Salphati, Zhonglin Hao, Stephanie Royer-Joo, Asha Nayak-Kapoor, Samir N. Khleif, Lisa Marshall, Ramses F. Sadek, W. Jay Ramsey, Kari M. Morrissey, Robin Dobbins
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-12 (2018)
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-12 (2018)
Background Indoleamine-2,3-dioxygenase 1 (IDO1) catalyzes the oxidation of tryptophan into kynurenine and is partially responsible for acquired immune tolerance associated with cancer. The IDO1 small molecule inhibitor navoximod (GDC-0919, NLG-919) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fc28cc7c59c4759fd428fd7ccd9573
https://doi.org/10.1186/s40425-018-0351-9
https://doi.org/10.1186/s40425-018-0351-9
Autor:
Richard P. Metz, George C. Prendergast, Andrew L. Mellor, Tracy L. McGaha, Mario R. Mautino, Lei Huang, Henrique Lemos
Publikováno v:
Immunological Reviews. 249:135-157
Enhanced amino acid catabolism is a common response to inflammation, but the immunologic significance of altered amino acid consumption remains unclear. The finding that tryptophan catabolism helped maintain fetal tolerance during pregnancy provided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217621b4d917ece56a7826b8c76915b5
https://doi.org/10.1111/j.1600-065x.2012.01149.x
https://doi.org/10.1111/j.1600-065x.2012.01149.x
Autor:
James Adams, Charles J. Link, Agnieszka Marcinowicz, Jiyuan Ke, Erik L. Brincks, Mario R. Mautino, Nicholas N. Vahanian, Michael Essmann, Benjamin A. Turner, Lifu Wang
Publikováno v:
Cancer Research. 78:3753-3753
The IDO pathway mediates immunosuppressive effects by metabolizing tryptophan (Trp) into kynurenine (Kyn). The depletion of Trp stimulates downstream signaling through nutrient sensors GCN2 and mTOR, while the production of Kyn stimulates signaling t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95efa09cd98cc4c384c1ecd218cb5d2d
https://doi.org/10.1158/1538-7445.am2018-3753
https://doi.org/10.1158/1538-7445.am2018-3753