Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mario Perkovic"'
Autor:
Christin Schmidt, Erik Haefner, Julia Gerbeth, Tim Beissert, Ugur Sahin, Mario Perkovic, Barbara S. Schnierle
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 743-754 (2022)
The arthritogenic alphavirus, chikungunya virus (CHIKV), is now present in almost 100 countries worldwide. Further spread is very likely, which raises public health concerns. CHIKV infections cause fever and arthralgia, which can be debilitating and
Externí odkaz:
https://doaj.org/article/3eab765183b54a88a514b3e5df52a8ac
Autor:
Christin Schmidt, Florian D. Hastert, Julia Gerbeth, Tim Beissert, Ugur Sahin, Mario Perkovic, Barbara S. Schnierle
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1374 (2022)
Alphaviruses such as the human pathogenic chikungunya virus (CHIKV) and Ross River virus (RRV) can cause explosive outbreaks raising public health concerns. However, no vaccine or specific antiviral treatment is yet available. We recently established
Externí odkaz:
https://doaj.org/article/1248d33fb49a4a7cb963048bb93ccafe
Publikováno v:
Viruses, Vol 13, Iss 7, p 1191 (2021)
Alphaviruses have a single-stranded, positive-sense RNA genome that contains two open reading frames encoding either the non-structural or the structural genes. Upon infection, the genomic RNA is translated into the non-structural proteins (nsPs). Ns
Externí odkaz:
https://doaj.org/article/ee608a9b748e42309e595b92a6f12701
Autor:
Mario Perkovic, Stefanie Gawletta, Tina Hempel, Silke Brill, Evelin Nett, Ugur Sahin, Tim Beissert
Publikováno v:
Molecular Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0346b160c1ae8f591fbf158217f734c8
https://doi.org/10.1016/j.ymthe.2023.01.019
https://doi.org/10.1016/j.ymthe.2023.01.019
Autor:
Mario Perkovic, Silke Brill, Tina Hempel, Erik Haefner, Tim Beissert, Özlem Türeci, René Becker, Stephanie Erbar, Kerstin C. Walzer, Annette B. Vogel, Ugur Sahin
Publikováno v:
Mol Ther
Here, we present a potent RNA vaccine approach based on a novel bipartite vector system using trans-amplifying RNA (taRNA). The vector cassette encoding the vaccine antigen originates from an alphaviral self-amplifying RNA (saRNA), from which the rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842ba511c356f2236fb9595eca9e338d
https://doi.org/10.1016/j.ymthe.2019.09.009
https://doi.org/10.1016/j.ymthe.2019.09.009
Publikováno v:
Viruses, Vol 13, Iss 1191, p 1191 (2021)
Viruses
Volume 13
Issue 7
Viruses, 13(7):1191
Viruses
Volume 13
Issue 7
Viruses, 13(7):1191
Alphaviruses have a single-stranded, positive-sense RNA genome that contains two open reading frames encoding either the non-structural or the structural genes. Upon infection, the genomic RNA is translated into the non-structural proteins (nsPs). Ns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11bd0420a01b038760f66b5a374266a
https://www.mdpi.com/1999-4915/13/7/1191
https://www.mdpi.com/1999-4915/13/7/1191
Autor:
Zeli Zhang, Mario Perkovic, Dieter Häussinger, Dirk Lindemann, Carsten Münk, Anucha Sangwiman, Kannan Balakrishnan, Qinyong Gu
Publikováno v:
Virology. 554
The family of human APOBEC3 (A3) restriction factors is formed by seven different proteins, A3A-D and A3F-H. Among these A3s, A3B harbors strong restriction activity against several retroviruses, such as SIV, and MLV. How lentiviruses and other retro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428397a88554d486c268820c8d557ac1
https://pubmed.ncbi.nlm.nih.gov/33333348
https://pubmed.ncbi.nlm.nih.gov/33333348
Autor:
Tim Beissert, Ekaterina Kinnear, Lena Wicke, Mario Perkovic, Kerstin C. Reuter, David C. Busse, Annette B. Vogel, Laura Lambert, Heinrich Haas, Ugur Sahin, John S. Tregoning, Stephen T. Reece, Stephanie Erbar
Publikováno v:
Molecular Therapy
New vaccine platforms are needed to address the time gap between pathogen emergence and vaccine licensure. RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95b4a78cdecceaeec3cb623a0519c11
http://hdl.handle.net/10044/1/56396
http://hdl.handle.net/10044/1/56396
Autor:
Stephanie Erbar, Lars Koste, Sebastian Kreiter, Abderraouf Selmi, Tim Beissert, Mario Perkovic, Mustafa Diken, Ugur Sahin, Kerstin C. Walzer, Özlem Türeci
Publikováno v:
Human Gene Therapy
Among nucleic acid–based delivery platforms, self-amplifying RNA (saRNA) vectors are of increasing interest for applications such as transient expression of recombinant proteins and vaccination. saRNA is safe and, due to its capability to amplify i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f5c34f3a75538fea8d3a7a7d249202
https://pubmed.ncbi.nlm.nih.gov/28877647
https://pubmed.ncbi.nlm.nih.gov/28877647
Autor:
Christoph Wigge, Victor-Valentin Hodirnau, Ulrike Endesfelder, Anja Seybert, Sebastian Malkusch, Margot P. Scheffer, Erin M. Schuman, Mike Heilemann, Michael Kunz, Mario Perkovic, Zhou Yu, Achilleas S. Frangakis, Stefanie Bunse
Publikováno v:
J. Struct. Biol.
Correlative microscopy incorporates the specificity of fluorescent protein labeling into high-resolution electron micrographs. Several approaches exist for correlative microscopy, most of which have used the green fluorescent protein (GFP) as the lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4da2d801908674ef90f4880392fd699