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pro vyhledávání: '"Mario Paolo Valenti"'
Autor:
Anne-Françoise Rochat, Claire-Anne Siegrist, Karen Lingnau, Else Marie Agger, Arun T. Kamath, Paul-Henri Lambert, Mario Paolo Valenti, Alexander von Gabain, Peter Andersen
Publikováno v:
European Journal of Immunology, Vol. 38, No 5 (2008) pp. 1247-56
Vaccine efficacy largely depends upon DC targeting and activation. The most potent TLR soluble ligands induce diffuse DC activation, which may be associated with marked pro-inflammatory responses and possibly adverse effects. This raises the concern
Autor:
Karen Lingnau, Claire-Anne Siegrist, Else Marie Agger, Arun T. Kamath, Peter Andersen, Anne-Françoise Rochat, Paul-Henri Lambert, Mario Paolo Valenti
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3683 (2008)
PLoS ONE
PLOS ONE, Vol. 3, No 11 (2008) P. e3683
PLoS ONE
PLOS ONE, Vol. 3, No 11 (2008) P. e3683
BACKGROUND: With the exception of some live vaccines, e.g. BCG, subunit vaccines formulated with "classical" adjuvants do not induce similar responses in neonates as in adults. The usual neonatal profile is characterized by lower levels of TH1-associ