Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Mario Ost"'
Autor:
Raquel Fernando, Anastasia V. Shindyapina, Mario Ost, Didac Santesmasses, Yan Hu, Alexander Tyshkovskiy, Sun Hee Yim, Jürgen Weiss, Vadim N. Gladyshev, Tilman Grune, José Pedro Castro
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Skeletal muscle aging is characterized by the loss of muscle mass, strength and function, mainly attributed to the atrophy of glycolytic fibers. Underlying mechanisms driving the skeletal muscle functional impairment are yet to be elucidated
Externí odkaz:
https://doaj.org/article/b1e477911453427b854cf104b5383a76
Autor:
Carla Igual Gil, Alina Löser, Kristina Lossow, Maria Schwarz, Daniela Weber, Tilman Grune, Anna P. Kipp, Susanne Klaus, Mario Ost
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Mitochondria play multifaceted roles in cellular function, and impairments across domains of mitochondrial biology are known to promote cellular integrated stress response (ISR) pathways as well as systemic metabolic adaptations. However, the tempora
Externí odkaz:
https://doaj.org/article/ad4838a411464622ab2d1947f5180c17
Autor:
Julia Münzker, Nadine Haase, Andreas Till, Robert Sucher, Sven-Bastiaan Haange, Linda Nemetschke, Thorsten Gnad, Elisabeth Jäger, Jiesi Chen, Sjaak J. Riede, Rima Chakaroun, Lucas Massier, Peter Kovacs, Mario Ost, Ulrike Rolle-Kampczyk, Nico Jehmlich, Juliane Weiner, John T. Heiker, Nora Klöting, Gudrun Seeger, Markus Morawski, Verena Keitel, Alexander Pfeifer, Martin von Bergen, Joerg Heeren, Ute Krügel, Wiebke K. Fenske
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-20 (2022)
Abstract Background Bariatric surgery remains the most effective therapy for adiposity reduction and remission of type 2 diabetes. Although different bariatric procedures associate with pronounced shifts in the gut microbiota, their functional role i
Externí odkaz:
https://doaj.org/article/6a766a44ecdc4c6c87577142da2ab281
Autor:
Jinit Masania, Patrick Wijten, Susanne Keipert, Mario Ost, Susanne Klaus, Naila Rabbani, Paul J. Thornalley
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102574- (2023)
Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health. This may be achieved by decreasing protein glycation by the reactiv
Externí odkaz:
https://doaj.org/article/215eeef27ff74f348faed50c016129ea
Autor:
Verena Coleman, Piangkwan Sa-Nguanmoo, Jeannette Koenig, Tim J. Schulz, Tilman Grune, Susanne Klaus, Anna P. Kipp, Mario Ost
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Mitochondrial dysfunction is usually associated with various metabolic disorders and ageing. However, salutary effects in response to mild mitochondrial perturbations have been reported in multiple organisms, whereas molecular regulators of
Externí odkaz:
https://doaj.org/article/ddd25ebf61ac4caa96259ace3a1b59f0
Autor:
Li Meng, Verena Coleman, Yu Zhao, Mario Ost, Anja Voigt, Annelies Bunschoten, Jaap Keijer, Katja Teerds, Susanne Klaus
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3557 (2021)
In the present investigation, we examined whether a change in whole body energy fluxes could affect ovarian follicular development, employing mice ectopically expressing uncoupling protein 1 in skeletal muscle (UCP1-TG). Female UCP1-TG and wild-type
Externí odkaz:
https://doaj.org/article/8e390087867c4c308c21255334da29c7
Autor:
Theresa Wolfram, Maria Schwarz, Michaela Reuß, Kristina Lossow, Mario Ost, Susanne Klaus, Tanja Schwerdtle, Anna P. Kipp
Publikováno v:
Antioxidants, Vol 9, Iss 11, p 1117 (2020)
N-acetylcysteine (NAC) is a frequently prescribed drug and known for its metal chelating capability. However, to date it is not well characterized whether NAC intake affects the homeostasis of essential trace elements. As a precursor of glutathione (
Externí odkaz:
https://doaj.org/article/8b59e770847b425da75ce9f64c7c04bb
Autor:
Mario Ost, Verena Coleman, Anja Voigt, Evert M. van Schothorst, Susanne Keipert, Inge van der Stelt, Sebastian Ringel, Antonia Graja, Thomas Ambrosi, Anna P. Kipp, Martin Jastroch, Tim J. Schulz, Jaap Keijer, Susanne Klaus
Publikováno v:
Molecular Metabolism, Vol 5, Iss 2, Pp 79-90 (2016)
Objective: Fibroblast growth factor 21 (FGF21) was recently discovered as stress-induced myokine during mitochondrial disease and proposed as key metabolic mediator of the integrated stress response (ISR) presumably causing systemic metabolic improve
Externí odkaz:
https://doaj.org/article/a4330a183a0148b6b0e46081c972ffba
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94689 (2014)
Transgenic (UCP1-TG) mice with ectopic expression of UCP1 in skeletal muscle (SM) show a phenotype of increased energy expenditure, improved glucose tolerance and increase substrate metabolism in SM. To investigate the potential role of skeletal musc
Externí odkaz:
https://doaj.org/article/24b0d152b79240fa918f56eb861ce3cb
Autor:
Erin E. Grundy, Lauren C. Shaw, Loretta Wang, Abigail V. Lee, James Castro Argueta, Daniel J. Powell, Mario Ostrowski, R. Brad Jones, C. Russell Y. Cruz, Heather Gordish-Dressman, Nicole P. Chappell, Catherine M. Bollard, Katherine B. Chiappinelli
Publikováno v:
Mobile DNA, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Transposable elements (TEs) are often expressed at higher levels in tumor cells than normal cells, implicating these genomic regions as an untapped pool of tumor-associated antigens. In ovarian cancer (OC), protein from the TE ERV-K is frequ
Externí odkaz:
https://doaj.org/article/ae60226c036b4df8a06919f4dc2441a1