Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Mario Monshouwer"'
Autor:
Loeckie De Zwart, Jan Snoeys, Frank Jacobs, Lilian Y. Li, Italo Poggesi, Peter Verboven, Ivo Goris, Ellen Scheers, Inneke Wynant, Mario Monshouwer, Rao N. V. S. Mamidi
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1107-1118 (2021)
Abstract Erdafitinib is a potent oral pan‐fibroblast growth factor receptor inhibitor being developed as oncology drug for patients with alterations in the fibroblast growth factor receptor pathway. Erdafitinib binds preferentially to α1‐acid gl
Externí odkaz:
https://doaj.org/article/8775373d94c14cc6bf4c7d8ef15cfec3
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background Cutaneous adverse drug reactions (CADR) associated with oncology therapy involve 45–100% of patients receiving kinase inhibitors. Such adverse reactions may include skin inflammation, infection, pruritus and dryness, symptoms th
Externí odkaz:
https://doaj.org/article/92101855f9264dff9ae6227bd4a8a7cc
Autor:
Ruben Boon, Manoj Kumar, Tine Tricot, Ilaria Elia, Laura Ordovas, Frank Jacobs, Jennifer One, Jonathan De Smedt, Guy Eelen, Matthew Bird, Philip Roelandt, Ginevra Doglioni, Kim Vriens, Matteo Rossi, Marta Aguirre Vazquez, Thomas Vanwelden, François Chesnais, Adil El Taghdouini, Mustapha Najimi, Etienne Sokal, David Cassiman, Jan Snoeys, Mario Monshouwer, Wei-Shou Hu, Christian Lange, Peter Carmeliet, Sarah-Maria Fendt, Catherine M. Verfaillie
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Hepatocytes grown in a dish are immature and do not metabolize compounds as a real liver would. Here, the authors supply stem cell-derived hepatocytes with amino acids at a higher concentration than nutritionally necessary, changing the metabolism of
Externí odkaz:
https://doaj.org/article/0a789642bd074590a245141b427513bf
Publikováno v:
JID Innovations, Vol 1, Iss 2, Pp 100009- (2021)
EGFR inhibitors used in oncology therapy modify the keratinocyte differentiation processes, impairing proper skin barrier formation and leading to cutaneous adverse drug reactions. To uncover the molecular signatures associated with cutaneous adverse
Externí odkaz:
https://doaj.org/article/19c458bef6b84fc38a63ef0db8e0d9b8
Autor:
Frank Jacobs, Loeckie de Zwart, I. Goris, Mario Monshouwer, Rao N.V.S. Mamidi, Lilian Y. Li, Italo Poggesi, Jan Snoeys, Peter Verboven, Ellen Scheers, Inneke Wynant
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1107-1118 (2021)
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1107-1118 (2021)
Erdafitinib is a potent oral pan‐fibroblast growth factor receptor inhibitor being developed as oncology drug for patients with alterations in the fibroblast growth factor receptor pathway. Erdafitinib binds preferentially to α1‐acid glycoprotei
Autor:
Stephanie Kourula, Merel Derksen, Ferran Jardi, Sophie Jonkers, Marjolein van Heerden, Peter Verboven, Veronique Theuns, Stijn Van Asten, Tinne Huybrechts, Annett Kunze, Ewa Frazer-Mendelewska, Ka Wai Lai, René Overmeer, Jamie Lee Roos, Robert G.J. Vries, Sylvia F. Boj, Mario Monshouwer, Farzin Pourfarzad, Jan Snoeys
Publikováno v:
European Journal of Pharmaceutical Sciences. :106481
Autor:
Thomas K van der Made, Jan Snoeys, Lieve Dillen, Ils Pijpers, Daniel Scotcher, Aleksandra Galetin, Sophie Jonkers, Mario Monshouwer, Amin Rostami-Hodjegan, Frank Jacobs, Annett Kunze, Kathleen Steemans, An Tuytelaars, Marie-Emilie Willemin
Publikováno v:
Willemin, M, Van Der Made, T K, Pijpers, I, Dillen, L, Kunze, A, Jonkers, S, Steemans, K, Tuytelaars, A, Jacobs, F, Monshouwer, M, Scotcher, D, Rostami-hodjegan, A, Galetin, A & Snoeys, J 2021, ' Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions ', Clinical Pharmacokinetics . https://doi.org/10.1007/s40262-021-01004-2
BackgroundEndogenous biomarkers are promising tools to assess transporter-mediated drug–drug interactions early in humans.MethodsWe evaluated on a common and validated in vitro system the selectivity of 4-pyridoxic acid (PDA), homovanillic acid (HV
Autor:
Khetam Alhilali, Jan Snoeys, Arun Tailor, Andrew Gibson, Mario Monshouwer, B. Kevin Park, Dean J. Naisbitt, Zaid Al-Attar, Xiaoli Meng
Publikováno v:
TOXICOLOGICAL SCIENCES
Telaprevir, a protease inhibitor, was used alongside PEGylated interferon-α and ribavirin to treat hepatitis C viral infections. The triple regimen proved successful; however, the appearance of severe skin reactions alongside competition from newer
Autor:
Nora Freyer, Selina Greuel, Fanny Knöspel, Nadja Strahl, Leila Amini, Frank Jacobs, Mario Monshouwer, Katrin Zeilinger
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 8, p 1724 (2017)
The derivation of hepatocytes from human induced pluripotent stem cells (hiPSC) is of great interest for applications in pharmacological research. However, full maturation of hiPSC-derived hepatocytes has not yet been achieved in vitro. To improve he
Externí odkaz:
https://doaj.org/article/a6fc41c4d933483dac994739f15e7140
Autor:
Barbara Birk, Jonathan Crozier, Catrina Stirling, Rob Taalman, Vikas Kumar, Magdalini Sachana, Alicia Paini, Boris P. Müller, Irene Manou, Mario Monshouwer, Federica De Gaetano, Alfonso Lostia, Hans Bender, Bruno Hubesch, Charles Laroche, Kirsty Reid, Iain Gardner, Renate Weissenhorn, Gianni Dal Negro, Timothy Rowan, Paul Benndorf, Ursula G. Sauer, A. Irizar, Leon van Aerts, Christian Desaintes, Katrin Schutte, David John, M. Aggarwal
Publikováno v:
Regulatory Toxicology and Pharmacology
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum Toxicokinetics and Read-Across to provide an overview on research activities to develop in vitro toxicokinetics methods and physiologically-based