Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Mario Mellado"'
Autor:
Eva M García-Cuesta, Pablo Martínez, Karthik Selvaraju, Gabriel Ulltjärn, Adrián Miguel Gómez Pozo, Gianluca D'Agostino, Sofia Gardeta, Adriana Quijada-Freire, Patricia Blanco Gabella, Carlos Roca, Daniel del Hoyo, Rodrigo Jiménez-Saiz, Alfonso García-Rubia, Blanca Soler Palacios, Pilar Lucas, Rosa Ayala-Bueno, Noelia Santander Acerete, Yolanda Carrasco, Carlos Oscar Sorzano, Ana Martinez, Nuria E Campillo, Lasse D Jensen, Jose Miguel Rodriguez Frade, César Santiago, Mario Mellado
Publikováno v:
eLife, Vol 13 (2024)
CXCR4 is a ubiquitously expressed chemokine receptor that regulates leukocyte trafficking and arrest in both homeostatic and pathological states. It also participates in organogenesis, HIV-1 infection, and tumor development. Despite the potential the
Externí odkaz:
https://doaj.org/article/f6355c90de494368a3bd46842c4d4614
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Heterozygous autosomal dominant mutations in the CXCR4 gene cause WHIM syndrome, a severe combined immunodeficiency disorder. The mutations primarily affect the C-terminal region of the CXCR4 chemokine receptor, specifically several potential phospho
Externí odkaz:
https://doaj.org/article/9795c5e1c7c34211b47b530839a2735b
Autor:
Blanca Soler Palacios, Ricardo Villares, Pilar Lucas, José Miguel Rodríguez-Frade, Ana Cayuela, Jonathan G. Piccirillo, Manuel Lombardía, David Delgado Gestoso, Miguel Fernández-García, Cristina Risco, Coral Barbas, Fernando Corrales, Carlos Oscar S. Sorzano, Nuria Martínez-Martín, José Javier Conesa, Francisco J. Iborra, Mario Mellado
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMacrophages are a heterogeneous population of innate immune cells that support tissue homeostasis through their involvement in tissue development and repair, and pathogen defense. Emerging data reveal that metabolism may control macrophag
Externí odkaz:
https://doaj.org/article/e00655a008f84d658709283a0e506648
Autor:
Ana Cayuela López, Eva M. García-Cuesta, Sofía R. Gardeta, José Miguel Rodríguez-Frade, Mario Mellado, José Antonio Gómez-Pedrero, Carlos Oscar S. Sorzano
Publikováno v:
Biological Imaging, Vol 3 (2023)
Current live-cell imaging techniques make possible the observation of live events and the acquisition of large datasets to characterize the different parameters of the visualized events. They provide new insights into the dynamics of biological proce
Externí odkaz:
https://doaj.org/article/cee7317c1ce34e1ba465d057fc7ec1ac
Autor:
Sofía R. Gardeta, Eva M. García-Cuesta, Gianluca D’Agostino, Blanca Soler Palacios, Adriana Quijada-Freire, Pilar Lucas, Jorge Bernardino de la Serna, Carolina Gonzalez-Riano, Coral Barbas, José Miguel Rodríguez-Frade, Mario Mellado
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Sphingolipids, ceramides and cholesterol are integral components of cellular membranes, and they also play important roles in signal transduction by regulating the dynamics of membrane receptors through their effects on membrane fluidity. Here, we co
Externí odkaz:
https://doaj.org/article/1b767aed2e974daa8551aaf33e88c4cf
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/01f4a225819a4c15985b3167d72ded3c
Autor:
Amalia Lamana, Ricardo Villares, Iria V. Seoane, Nuria Andrés, Pilar Lucas, Paul Emery, Edward M. Vital, Ana Triguero-Martínez, Ana Marquez, Ana M. Ortiz, Robin Maxime, Carmen Martínez, Javier Martín, Rosa P. Gomariz, Frederique Ponchel, Isidoro González-Álvaro, Mario Mellado
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by an autoimmune response in the joints and an exacerbation of cytokine responses. A minority of patients with RA experience spontaneous remission, but most will show moderate/
Externí odkaz:
https://doaj.org/article/4143ce71baa54562bc1f3ffd66bc1924
Autor:
Jorge Bernardino de la Serna, Mario Mellado, Michael L. Dustin, Maria F. Garcia-Parajo, Dimitrios Morikis
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
Externí odkaz:
https://doaj.org/article/42ff4718136c45b7bf791f48c900bfdc
Autor:
Manuel Olazábal-Morán, Miriam Sánchez-Ortega, Laura Martínez-Muñoz, Carmen Hernández, Manuel S. Rodríguez, Mario Mellado, Ana C. Carrera
Publikováno v:
Cells, Vol 10, Iss 11, p 2803 (2021)
3-Poly-phosphoinositides (PIP3) regulate cell survival, division, and migration. Both PI3-kinase (phosphoinositide-3-kinase) and PTEN (phosphatase and tensin-homolog in chromosome 10) control PIP3 levels, but the mechanisms connecting PI3-kinase and
Externí odkaz:
https://doaj.org/article/ffa2fdd3b6c6481f85c696403eaaae8b
Autor:
Eva M. García-Cuesta, César A. Santiago, Jesús Vallejo-Díaz, Yasmina Juarranz, José Miguel Rodríguez-Frade, Mario Mellado
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Chemokine receptors are members of the G protein-coupled receptor superfamily. These receptors are intimately involved in cell movement, and thus play a critical role in several physiological and pathological situations that require the precise regul
Externí odkaz:
https://doaj.org/article/378725793a7f4f3c894745c8c99118be