Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mario Malfavon"'
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3
Externí odkaz:
https://doaj.org/article/c0dcaba8ffc04890ade94c8b75b21509
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a16cb8fb950d46f9ab274a050ec42452
Autor:
Anaamika Campeau, Robert H. Mills, Marie Blanchette, Kaja Bajc, Mario Malfavon, Roeben N. Munji, Liwen Deng, Bryan Hancock, Kathryn A. Patras, Joshua Olson, Victor Nizet, Richard Daneman, Kelly Doran, David J. Gonzalez
Publikováno v:
mSystems, Vol 5, Iss 4 (2020)
ABSTRACT Group B Streptococcus (GBS) remains the leading cause of neonatal meningitis, a disease associated with high rates of adverse neurological sequelae. The in vivo relationship between GBS and brain tissues remains poorly characterized, partly
Externí odkaz:
https://doaj.org/article/6937f2e3052a4afdbe7d31c35a75fdc5
Autor:
Caila A. Pilo, Timothy R. Baffi, Alexandr P. Kornev, Maya T. Kunkel, Mario Malfavon, Dong-Hui Chen, Leigh-Ana Rossitto, Daniel X. Chen, Liang-Chin Huang, Cheryl Longman, Natarajan Kannan, Wendy H. Raskind, David J. Gonzalez, Susan S. Taylor, George Gorrie, Alexandra C. Newton
Publikováno v:
Sci Signal
Science signaling, vol 15, iss 753
Science signaling, vol 15, iss 753
Spinocerebellar ataxia type 14 (SCA14) is a neurodegenerative disease caused by germline variants in the diacylglycerol (DAG)/Ca 2+ -regulated protein kinase Cγ (PKCγ), leading to Purkinje cell degeneration and progressive cerebellar dysfunction. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fd68095d74e8cad973b0705b004708
https://doi.org/10.1126/scisignal.abk1147
https://doi.org/10.1126/scisignal.abk1147
Autor:
Robert H. Mills, Parambir S. Dulai, Yoshiki Vázquez-Baeza, Consuelo Sauceda, Noëmie Daniel, Romana R. Gerner, Lakshmi E. Batachari, Mario Malfavon, Qiyun Zhu, Kelly Weldon, Greg Humphrey, Marvic Carrillo-Terrazas, Lindsay DeRight Goldasich, MacKenzie Bryant, Manuela Raffatellu, Robert A. Quinn, Andrew T. Gewirtz, Benoit Chassaing, Hiutung Chu, William J. Sandborn, Pieter C. Dorrestein, Rob Knight, David J. Gonzalez
Publikováno v:
Nature microbiology, vol 7, iss 2
Ulcerative colitis (UC) is driven by disruptions in host-microbiota homoeostasis, but current treatments exclusively target host inflammatory pathways. To understand how host-microbiota interactions become disrupted in UC, we collected and analysed s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d462ea892b86b809f0ce89c942c6623e
https://pubmed.ncbi.nlm.nih.gov/35087228
https://pubmed.ncbi.nlm.nih.gov/35087228
Autor:
Caila A. Pilo, Timothy R. Baffi, Alexandr P. Kornev, Maya T. Kunkel, Mario Malfavon, Dong-Hui Chen, Liang-Chin Huang, Cheryl Longman, Natarajan Kannan, Wendy Raskind, David J. Gonzalez, Susan S. Taylor, George Gorrie, Alexandra C. Newton
Spinocerebellar ataxia type 14 (SCA14) is a neurodegenerative disease caused by germline variants in the diacylglycerol (DG)/Ca2+-regulated protein kinase C gamma (PKCγ), leading to Purkinje cell degeneration and progressive cerebellar dysfunction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0968ce8ab5dd66554e01a82800d9ec5
https://doi.org/10.1101/2021.06.24.449810
https://doi.org/10.1101/2021.06.24.449810
Autor:
Victor Nizet, Robert H. Mills, Roeben N. Munji, Mario Malfavon, Richard Daneman, Anaamika Campeau, Kelly S. Doran, Liwen Deng, Joshua Olson, Kaja Bajc, Marie Blanchette, David Gonzalez, Bryan Hancock, Kathryn A. Patras
Publikováno v:
mSystems, Vol 5, Iss 4 (2020)
mSystems
mSystems, Vol 5, Iss 4, p e00368-20 (2020)
mSystems, vol 5, iss 4
mSystems
mSystems, Vol 5, Iss 4, p e00368-20 (2020)
mSystems, vol 5, iss 4
Group B Streptococcus (GBS) meningitis remains a major cause of poor health outcomes very early in life. Both the host-pathogen relationship leading to disease and the massive host response to infection contributing to these poor outcomes are orchest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86eb20edabf675a4cad625349ac46649
https://journals.asm.org/doi/10.1128/mSystems.00368-20
https://journals.asm.org/doi/10.1128/mSystems.00368-20
Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes
Autor:
Frédéric Gachon, Mario Malfavon, Geoffrey Weiner, Koji L. Foreman, Clare R. Quirk, Sara Elmsaouri, Stefan Leutgeb, Tongcheng Qian, Caterina P. Profaci, Richard Daneman, Tamara C. Chan, Eric V. Shusta, Meghan Rossi, Michael R. Gorman, Robert S. Pulido, Marie Blanchette, Benjamin D. Weger, Aaron Deng, Roeben N. Munji
Publikováno v:
Neuron
Neuron, vol 108, iss 5
Neuron, vol 108, iss 5
The blood vessels in the central nervous system (CNS) have a series of unique properties, termed the blood-brain barrier (BBB), which stringently regulate the entry of molecules into the brain, thus maintaining proper brain homeostasis. We sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84db7d1da78cfc5b1019bbb88567f3ce
https://pubmed.ncbi.nlm.nih.gov/32979312
https://pubmed.ncbi.nlm.nih.gov/32979312