Výsledky vyhledávání - "Mario Loriga"

Synthesis and antiviral activity of new phenylimidazopyridines and N-benzylidenequinolinamines derived by molecular simplification of phenylimidazo[4,5-g]quinolines

Autor: Irene Briguglio, Gabriele Giliberti, Giuseppina Sanna, Sandra Piras, Pamela Farci, Mario Loriga, Giuseppe Paglietti, Cristina Ibba, Roberta Loddo, Paolo La Colla, Paola Corona, Antonio Carta

Publikováno v: European Journal of Medicinal Chemistry. 84:8-16

Continuing our program of research concerning the antiviral activity of a wide series of new angular and linear azolo bicyclic and tricyclic derivatives, now we have simplified and modified the 4-chloro-2-(4-nitrophenyl)-3H-imidazo[4,5-g]quinoline 1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8123806e99964f84223375bfcb93c57a
https://doi.org/10.1016/j.ejmech.2014.07.011

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2-Arylbenzimidazoles as Antiviral and Antiproliferative Agents-Part 2

Autor: Paola Corona, Bernardetta Busonera, Roberta Loddo, Paolo La Colla, Antonio Carta, Gabriella Vitale, Mario Loriga, Giuseppe Paglietti, Esther Marongiu, David Collu

Publikováno v: Medicinal Chemistry. 5:507-516

In prosecution of an anti-Flaviviridae project a new series of variously substituted 2-diphenyl-benzimidazoles were synthesized and tested in vitro for antiviral and antiproliferative activities. Compounds were tested in cell-based assays against vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d89dd0a9fa19cf2e3a7fe07951c3fe
https://doi.org/10.2174/157340609790170542

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Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: Evaluation of in vitro anti-cancer and anti-folate activities

Autor: Paola Corona, Mario Loriga, Giuseppe Paglietti, Stefania Ferrari, M. Paola Costi

Publikováno v: European Journal of Medicinal Chemistry. 43:189-203

Several diamino quinoxalines were designed, synthesized and evaluated as anti-tumor agents. Two compounds showed the most potent cytotoxic activities against the leukemia CCRF-CEM cell line (GI(50)0.01microM) and the ovarian cancer cell line OVCAR-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0f1c7710fa7c329fc1cf48fcf18399
https://doi.org/10.1016/j.ejmech.2007.03.035

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4-Substituted anilino imidazo[1,2-a] and triazolo[4,3-a]quinoxalines. Synthesis and evaluation of in vitro biological activity

Autor: Giuseppe Paglietti, Paolo La Colla, Giuseppina Sanna, Gabriella Vitale, Gabriella Collu, Paola Corona, Mario Loriga, Roberta Loddo

Publikováno v: European Journal of Medicinal Chemistry. 41:1102-1107

Fifteen imidazo[1,2-a] and [1,2,4]triazolo[4,3-a]quinoxalines were prepared. These compounds bear at position 4 various substituents related to the moieties present in classical and non-classical antifolic agents. And we evaluated in vitro antimicrob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f00d6adc6dae4eb19575d335d83331
https://doi.org/10.1016/j.ejmech.2006.05.015

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Novel 3-benzoyl-2-piperazinylquinoxaline derivatives as potential antitumor agents

Autor: Stefania Ferrari, Mario Loriga, M. Paola Costi, Giuseppe Paglietti, Antonio Carta, Sandra Piras

Publikováno v: Journal of Heterocyclic Chemistry. 43:541-548

A series of new benzoylquinoxaline derivatives (7-26) was synthesized and evaluated for antitumor activity against a panel of 60 human cell lines at the NCI of Bethesda. Among the compounds which have passed the preliminary screening, compound 23 exh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fc3db4b63ec84b52e93a4e06dfa0d3
https://doi.org/10.1002/jhet.5570430304

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Synthesis of Variously Substituted 3-Phenoxymethyl Quinoxalin-2-Ones and Quinoxalines Capable to Potentiate In Vitro the Antiproliferative Activity of Anticancer Drugs in Multi-Drug Resistant Cell Lines

Autor: Antonio Carta, Sandra Piras, Gabriella Collu, Mario Loriga, Paolo La Colla, Roberta Loddo, Bernardetta Busonera, Giuseppe Paglietti

Publikováno v: Medicinal Chemistry. 2:113-122

Two series of 1,6-dimethyl-3-phenoxymethylquinoxalin-2-ones and 1-benzyl-3-phenoxymethyl-7-trifluoromethylquinoxalin-2-ones, and a series of 2-benzyloxy-3-phenoxymethyl-7-trifluoromethylquinoxaline were synthesized. Their capability to restore/potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c81a11dc6606de05156dd6bb444e51b
https://doi.org/10.2174/157340606776056197

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Quinoxalin-2-ones

Autor: Mario Loriga, Antonio Carta, Leonardo Antonio Sechi, Stefania Anna Lucia Zanetti

Publikováno v: Il Farmaco. 58:1251-1255

A new series of 3-alkyl-, 3-trifluoromethyl-, 3-carboxyethyl- and 3-bromomethylquinoxaline-2-ones and 2,3-bis(bromomethyl)quinoxalines bearing Cl, CF3, morpholine on the benzo-moiety, were synthesised and submitted to a preliminary in vitro evaluatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5fc141f4df5947ac24c77f783d7c79c
https://doi.org/10.1016/s0014-827x(03)00198-8

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Quinoxaline chemistry. Part 16. 4-Substituted anilino and 4-substituted phenoxymethyl pyrrolo[1,2-a]quinoxalines and N-[4-(pyrrolo[1,2-a]quinoxalin-4-yl)amino and hydroxymethyl]benzoyl glutamates. Synthesis and evaluation of in vitro biological activity

Autor: Sergio Alleca, Paolo La Colla, Paola Corona, Mario Loriga, Valeria Mascia, Bernardetta Busonera, Giuseppe Paglietti, Roberta Loddo

Publikováno v: Il Farmaco. 58:639-650

Twenty eight pyrrolo[1,2-a]quinoxalines bearing at position 4 various substituents related to the moieties present in classical and non classical antifolic agents were prepared and evaluated in vitro for antiproliferative activity. In an in vitro scr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd16b39981a08516b44dba6366eef73
https://doi.org/10.1016/s0014-827x(03)00101-0

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Synthesis and evaluation for biological activity of 3-alkyl and 3-halogenoalkyl-quinoxalin-2-ones variously substituted. Part 4

Autor: Antonio Carta, Paolo Sanna, Mario Loriga, Roberta Loddo, Paolo La Colla, Maria Giovanna Setzu

Publikováno v: Il Farmaco. 57:19-25

A new series of 3-isopropyl-, 3-trifluoromethyl- and 3-bromomethylquinoxaline-2-ones variously substituted on the benzo-moiety were synthesized and submitted to a preliminary in vitro evaluation for antibacterial, antifungal and anti-HIV activities.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912fbcec55c044e23a2432ab8398a8a2
https://doi.org/10.1016/s0014-827x(01)01153-3

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Quinoxaline chemistry. Part 13: 3-carboxy-2-benzylamino-substituted quinoxalines and N-[4-[(3-carboxyquinoxalin-2-yl) aminomethyl]benzoyl]-l-glutamates: synthesis and evaluation of in vitro anticancer activity

Autor: Giuseppe Paglietti, Gabriella Vitale, Paola Corona, Mario Loriga

Publikováno v: Il Farmaco. 55:77-86

Among a new series of 28 3-carboxy or carbethoxy quinoxalines bearing a substituted benzylamino or N-[4-(aminomethyl)benzoyl]glutamate group on position 2 of the ring and various substituents at C-6, 7 positions, 21 were selected at the National Canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb51efe88e2f8109d42c68a9d257060a
https://doi.org/10.1016/s0014-827x(99)00119-6

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