Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mario L. Suva"'
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Background Multiple glioblastoma studies have described a mesenchymal (MES) state, with each study defining the MES program by distinct sets of genes and highlighting distinct functional associations, including both immune activation and sup
Externí odkaz:
https://doaj.org/article/1a59b0d2cf944f71900d88104d2b915b
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/01df8602e3354becb65aef2a80d047ef
Autor:
Zachary J. Reitman, Brenton R. Paolella, Guillaume Bergthold, Kristine Pelton, Sarah Becker, Robert Jones, Claire E. Sinai, Hayley Malkin, Ying Huang, Leslie Grimmet, Zachary T. Herbert, Yu Sun, Jessica L. Weatherbee, John A. Alberta, John F. Daley, Orit Rozenblatt-Rosen, Alexandra L. Condurat, Kenin Qian, Prasidda Khadka, Rosalind A. Segal, Daphne Haas-Kogan, Mariella G. Filbin, Mario L. Suva, Aviv Regev, Charles D. Stiles, Mark W. Kieran, Liliana Goumnerova, Keith L. Ligon, Alex K. Shalek, Pratiti Bandopadhayay, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.
Externí odkaz:
https://doaj.org/article/751f4dad2db84b0f893ba0445a18b1bd
Autor:
Tobias Kessler, Ling Hai, Dirk C Hoffmann, Henriette Mandelbaum, Ruifan Xie, Jakob Ito, Erik Jung, Sophie Weil, Philipp Sievers, Varun Venkataramani, Daniel Dominguez Azorin, Kathi Ernst, Denise Reibold, Rainer Will, Mario L Suva, Christel Herold-Mende, Felix Sahm, Frank Winkler, Matthias Schlesner, Wolfgang Wick
Publikováno v:
WFNOS 2022 Abstract Book.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ec0833c056fda94724e62d7fb8db7c6
https://doi.org/10.14791/btrt.2022.10.f-1285
https://doi.org/10.14791/btrt.2022.10.f-1285
Autor:
Avishai Gavish, Michael Tyler, Dor Simkin, Daniel Kovarsky, L. Nicolas Gonzalez Castro, Debdatta Halder, Rony Chanoch-Myers, Julie Laffy, Michael Mints, Alissa R. Greenwald, Adi Wider, Rotem Tal, Avishay Spitzer, Toshiro Hara, Amit Tirosh, Sidharth V. Puram, Mario L. Suva, Itay Tirosh
Each tumor contains malignant cells that differ in genotype, phenotype, and in their interactions with the tumor micro-environment (TME). This results in distinct integrated cellular states that govern intra-tumor heterogeneity (ITH), a central chall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::595e5c5dba013591faff1a41a7e1f77f
https://doi.org/10.1101/2021.12.19.473368
https://doi.org/10.1101/2021.12.19.473368
Autor:
Ling Hai, Dirk C. Hoffmann, Robin J. Wagener, Daniel D. Azorin, David Hausmann, Ruifan Xie, Magnus-Carsten Huppertz, Julien Hiblot, Philipp Sievers, Sophie Heuer, Jakob Ito, Gina Cebulla, Alexandros Kourtesakis, Leon D. Kaulen, Miriam Ratliff, Henriette Mandelbaum, Erik Jung, Ammar Jabali, Sandra Horschitz, Kati J. Ernst, Denise Reibold, Uwe Warnken, Varun Venkataramani, Rainer Will, Mario L. Suvà, Christel Herold-Mende, Felix Sahm, Frank Winkler, Matthias Schlesner, Wolfgang Wick, Tobias Kessler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. However, the determination of TM-interconnectivity in individual tumors is challenging and the impact on patie
Externí odkaz:
https://doaj.org/article/9132ac5efdf949f4b787da50b96b4fa0
Autor:
J. Bryan Iorgulescu, Neil Ruthen, Ryuhjin Ahn, Eleni Panagioti, Prafulla C. Gokhale, Martha Neagu, Maria C. Speranza, Benjamin K. Eschle, Kara M. Soroko, Raziye Piranlioglu, Meenal Datta, Shanmugarajan Krishnan, Kathleen B. Yates, Gregory J. Baker, Rakesh K. Jain, Mario L. Suvà, Donna Neuberg, Forest M. White, E. Antonio Chiocca, Gordon J. Freeman, Arlene H. Sharpe, Catherine J. Wu, David A. Reardon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct differences in their responses to immunotherapy.MethodsTo decipher the cell-intri
Externí odkaz:
https://doaj.org/article/0d4ef411871943b490bc6d2c4f558fb2
Autor:
Grant L. Lin, Surya Nagaraja, Mariella G. Filbin, Mario L. Suvà, Hannes Vogel, Michelle Monje
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-12 (2018)
Abstract Diffuse intrinsic pontine glioma (DIPG) is a universally fatal malignancy of the childhood central nervous system, with a median overall survival of 9–11 months. We have previously shown that primary DIPG tissue contains numerous tumor-ass
Externí odkaz:
https://doaj.org/article/ede1960be8874634b6ebe911f534393b
Autor:
Esther Rheinbay, Mario L. Suvà, Shawn M. Gillespie, Hiroaki Wakimoto, Anoop P. Patel, Mohammad Shahid, Ozgur Oksuz, Samuel D. Rabkin, Robert L. Martuza, Miguel N. Rivera, David N. Louis, Simon Kasif, Andrew S. Chi, Bradley E. Bernstein
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1567-1579 (2013)
Glioblastoma (GBM) is thought to be driven by a subpopulation of cancer stem cells (CSCs) that self-renew and recapitulate tumor heterogeneity yet remain poorly understood. Here, we present a comparative analysis of chromatin state in GBM CSCs that r
Externí odkaz:
https://doaj.org/article/61ad20f8b8db4ae4a36b359023e2d865