Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Mario Jolicoeur"'
Autor:
Jorgelindo da Veiga Moreira, Nancy Nleme, Laurent Schwartz, Kim Leclerc-Desaulniers, Euridice Carmona, Anne-Marie Mes-Masson, Mario Jolicoeur
Publikováno v:
Cancers, Vol 16, Iss 2, p 355 (2024)
Ovarian cancer remains a significant challenge, especially in platinum-resistant cases where treatment options are limited. In this study, we investigated the potential of methylene blue (MB) as a metabolic therapy and complementary treatment approac
Externí odkaz:
https://doaj.org/article/f15e79cc4c834be5b3df5d4babc27e61
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Yarrowia lipolytica is a non-conventional yeast with promising industrial potentials for lipids and citrate production. It is also widely used for studying mitochondrial respiration due to a respiratory chain like those of mammalian cells. I
Externí odkaz:
https://doaj.org/article/097d84ab3eec4670915c217ffef3477a
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-13 (2019)
Abstract Background Microalgae have been proposed as potential platform to produce lipid-derived products, such as biofuels. Knowledge on the intracellular carbon flow distribution may identify key metabolic processes during lipid synthesis thus refi
Externí odkaz:
https://doaj.org/article/88e798454033432fb4e44ae00122a28e
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
The occurrence of mitochondrial respiration has allowed evolution toward more complex and advanced life forms. However, its dysfunction is now also seen as the most probable cause of one of the biggest scourges in human health, cancer. Conventional c
Externí odkaz:
https://doaj.org/article/827ff2da8fea4f7e814cfc9f92ea4254
Autor:
Léa Montégut, Pablo César Martínez-Basilio, Jorgelindo da Veiga Moreira, Laurent Schwartz, Mario Jolicoeur
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231770 (2020)
The Warburg effect, a hallmark of cancer, has recently been identified as a metabolic limitation of Chinese Hamster Ovary (CHO) cells, the primary platform for the production of monoclonal antibodies (mAb). Metabolic engineering approaches, including
Externí odkaz:
https://doaj.org/article/df37f8523903424282e60b3bb1d0d04f
Autor:
Jorgelindo da Veiga Moreira, Lenny De Staercke, Pablo César Martínez-Basilio, Sandrine Gauthier-Thibodeau, Léa Montégut, Laurent Schwartz, Mario Jolicoeur
Publikováno v:
Metabolites, Vol 11, Iss 6, p 344 (2021)
Tumor cells are known to favor a glycolytic metabolism over oxidative phosphorylation (OxPhos), which takes place in mitochondria, to produce the energy and building blocks essential for cell maintenance and cell growth. This phenotypic property of t
Externí odkaz:
https://doaj.org/article/dccd2ddf97ef430a8313c92cab2c5c23
Publikováno v:
AIMS Bioengineering, Vol 3, Iss 3, Pp 319-336 (2016)
HEK293 cells are gaining in interest for the production of recombinant proteins. However, further understanding and engineering of cell metabolism are still needed to improve protein titers. The importance of G6PDH has already been studied regarding
Externí odkaz:
https://doaj.org/article/aa417435e5ae43048ba3e9ea88ed147d
Autor:
Manon Bardyn, Jingkui Chen, Michaël Dussiot, David Crettaz, Lucas Schmid, Emmanuel Längst, Pascal Amireault, Jean-Daniel Tissot, Mario Jolicoeur, Michel Prudent
Publikováno v:
Metabolites, Vol 10, Iss 6, p 226 (2020)
After blood donation, the red blood cells (RBCs) for transfusion are generally isolated by centrifugation and then filtrated and supplemented with additive solution. The consecutive changes of the extracellular environment participate to the occurren
Externí odkaz:
https://doaj.org/article/f02268a1d1a942a49446c21d6a1f1c9d
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171440 (2017)
We present a method for computing thermodynamically feasible elementary flux modes (tEFMs) using equilibrium constants without need of internal metabolite concentrations. The method is compared with the method based on a binary distinction between re
Externí odkaz:
https://doaj.org/article/2cf2cd42618b475cbc90c4cc76e42a08
Autor:
Mario Jolicoeur
Publikováno v:
AIMS Bioengineering, Vol 1, Iss 1, Pp 1-12 (2014)
In the context of the launching of this new journal, we propose a forum to the community of researchers interested and involved in, or even simply questioning the why, what, how, and when of modeling cell or cell culture behavior. To start the discus
Externí odkaz:
https://doaj.org/article/44f31e1f96d443a5ad95d768640c9571