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Akademický článek

THE ROLE OF GABAB REGULATORY PROTEIN KCTD16 IN PAIN MODULATION

Autor: Daniel Vasconcelos, Mario Heles, Pavel Adamek, Jiří Paleček

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S723- (2023)

Externí odkaz: https://doaj.org/article/4114d8d59fee4e168e2fb48dcfe372f2

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Akademický článek

Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn

Autor: Mario Heles, Petra Mrozkova, Dominika Sulcova, Pavel Adamek, Diana Spicarova, Jiri Palecek

Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-11 (2021)

Abstract Background Opioid analgesics remain widely used for pain treatment despite the related serious side effects. Some of those, such as opioid tolerance and opioid-induced hyperalgesia may be at least partially due to modulation of opioid recept

Externí odkaz: https://doaj.org/article/283da2c846314e67b4b0e0c8da04c39f

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Dual PI3Kδ/γ Inhibitor Duvelisib Prevents Development of Neuropathic Pain in Model of Paclitaxel-Induced Peripheral Neuropathy

Autor: Pavel Adamek, Mario Heles, Anirban Bhattacharyya, Monica Pontearso, Jakub Slepicka, Jiri Palecek

Publikováno v: J Neurosci

The development of painful paclitaxel-induced peripheral neuropathy (PIPN) represents a major dose-limiting side effect of paclitaxel chemotherapy. Here we report a promising effect of duvelisib (Copiktra), a novel FDA-approved PI3Kδ/γ isoform-spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a159783ae93c30ebb89cb939f6269574
https://doi.org/10.1523/jneurosci.1324-21.2021

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Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn

Autor: Dominika Sulcova, Mario Heles, Pavel Adamek, Jiri Palecek, Petra Mrozkova, Diana Spicarova

Publikováno v: Journal of neuroinflammation, Vol. 18, no.1, p. 279 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-11 (2021)

Background Opioid analgesics remain widely used for pain treatment despite the related serious side effects. Some of those, such as opioid tolerance and opioid-induced hyperalgesia may be at least partially due to modulation of opioid receptors (OR)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f35c8dc085bd7a24db4e7045cf0b53
https://hdl.handle.net/2078.1/270613

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Mechanical allodynia and enhanced responses to capsaicin are mediated by PI3K in a paclitaxel model of peripheral neuropathy

Autor: Mario Heles, Jiri Palecek, Pavel Adamek

Publikováno v: Neuropharmacology. 146

Paclitaxel chemotherapy treatment often leads to neuropathic pain resistant to available analgesic treatments. Recently spinal Toll-like receptor 4 (TLR4) and the transient receptor potential cation channel subfamily V member 1 (TRPV1) were identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2e86f122f1e06a2608542c64913012
https://pubmed.ncbi.nlm.nih.gov/30471295

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PI3K inhibition reduces mechanical allodynia and sensitization of spinal TRPV1 receptors in a model of paclitaxel-induced painful neuropathy

Autor: Jiri Palecek, Pavel Adamek, Mario Heles

Publikováno v: IBRO Reports. 6:S294

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f03557ed2ae52df4a57be974fd2aee5
https://doi.org/10.1016/j.ibror.2019.07.910

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