Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Mario Halic"'
Autor:
Harsh Nagpal, Ahmad Ali-Ahmad, Yasuhiro Hirano, Wei Cai, Mario Halic, Tatsuo Fukagawa, Nikolina Sekulić, Beat Fierz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A. Contacting CENP-A nucleosomes, the constitutive centromere associated network (CCAN) and the kinetochore assemble, connecting the centromere to spindle
Externí odkaz:
https://doaj.org/article/61ccb81d61444f478e9b161118cbf73a
Autor:
Luka Bacic, Guillaume Gaullier, Anton Sabantsev, Laura C Lehmann, Klaus Brackmann, Despoina Dimakou, Mario Halic, Graeme Hewitt, Simon J Boulton, Sebastian Deindl
Publikováno v:
eLife, Vol 10 (2021)
The chromatin remodeler ALC1 is recruited to and activated by DNA damage-induced poly(ADP-ribose) (PAR) chains deposited by PARP1/PARP2/HPF1 upon detection of DNA lesions. ALC1 has emerged as a candidate drug target for cancer therapy as its loss con
Externí odkaz:
https://doaj.org/article/f3f3bd2076484817a1cc27acc9027411
Autor:
Silvija Bilokapic, Mario Halic
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Set2 methyltransferase catalyzes the lysine 36 methylation of histone H3 (H3K36me) and the enzyme is mutated in many cancers. The authors provide mechanistic insights into how Set2 methylates nucleosomes by determining the 3.8 Å cryo-EM structure of
Externí odkaz:
https://doaj.org/article/0672ca4ad221431ba246d83969a70d64
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Abstract Nucleosomes, the basic unit of chromatin, are repetitively spaced along DNA and regulate genome expression and maintenance. The long linear chromatin molecule is extensively condensed to fit DNA inside the nucleus. How distant nucleosomes in
Externí odkaz:
https://doaj.org/article/f602bcecdea24fc09731f8793c1cc913
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nucleosomes are dynamic and can move along DNA in an uncatalyzed manner but little is known about the mechanisms of histone octamer translocation. Here the authors present cryo-EM structures of nucleosomes in differently organized histone octamer and
Externí odkaz:
https://doaj.org/article/4b6d6997c4ab43a8a267659de1b41813
Autor:
Paola Pisacane, Mario Halic
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
While RNA interference is a highly conserved mechanism of gene regulation, how Argonaute-bound small RNAs are targeted for degradation is not well understood. Here the authors show that Cid14 and Cid16 target Argonaute-bound small RNAs for degradatio
Externí odkaz:
https://doaj.org/article/b354a2a9d2b54d4498ba1ed17e081328
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189040 (2017)
H1 linker histones are small basic proteins that have a key role in the formation and maintenance of higher-order chromatin structures. Additionally, many examples have shown that linker histones play an important role in gene regulation, modulated b
Externí odkaz:
https://doaj.org/article/45feeb4d765645768c05798c8d7b8779
Publikováno v:
Nature.
Pioneer transcription factors have the ability to access DNA in compacted chromatin1. Multiple transcription factors can bind together to a regulatory element in a cooperative way, and cooperation between the pioneer transcription factors OCT4 (also
Autor:
Cornelia Broenner, Pablo Monteagudo, Stefan Canzar, Parastou Kohvaei, Haris Amedi, Mario Halic
Publikováno v:
Nucleic acids research. 50(10)
Heterochromatic silencing is thought to occur through a combination of transcriptional silencing and RNA degradation, but the relative contribution of each pathway is not known. In this study, we analyzed RNA Polymerase II (RNA Pol II) occupancy and
Publikováno v:
Nature. 585:609-613
Breaks in DNA strands recruit the protein PARP1 and its paralogue PARP2 to modify histones and other substrates through the addition of mono- and poly(ADP-ribose) (PAR)1,2,3,4,5. In the DNA damage responses, this post-translational modification occur