Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Mario Guzzi"'
Autor:
Sherry X. Lu, Eric M. Parker, Mario Guzzi, Robert A. Hodgson, Xiaoping Zhang, Michael W. Miller, Andrew Stamford, Carina J. Bleickardt, Geoffrey B. Varty, Jack D. Scott, Deborra Mullins
Publikováno v:
European Journal of Pharmacology. 730:157-163
Overactivity of the hypothalamic-pituitary-adrenal (HPA) axis has been linked to affective disorders such as anxiety and depression. Dampening HPA activity has, therefore, been considered as a possible means of treating affective disorders. Given the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63790802699346bcb765c3bc76a8cd9
https://doi.org/10.1016/j.ejphar.2014.02.027
https://doi.org/10.1016/j.ejphar.2014.02.027
Autor:
R. Woscholski, Emanuele Grilli, E. Gatti, Giovanni Isella, Pengki Li, Hanan Dery, Christoph Lange, Dhara Trivedi, Sangam Chatterjee, F. Ciccacci, Yang Song, Fabio Pezzoli, Stefano Cecchi, Mario Guzzi, Anna Giorgioni, Federico Bottegoni, N. S. Köster, Alberto Ferrari
Publikováno v:
ECS Transactions. 50:831-836
Ge is emerging as an interesting material for spintronic applications. We demonstrate that in SiGe heterostructures strain and quantum confinement effects can be used to tailor spin related properties enhancing the spin polarization of injected carri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5a737c97e41c4fee3b1f038f54bc785
https://doi.org/10.1149/05009.0831ecst
https://doi.org/10.1149/05009.0831ecst
Autor:
Jennifer Smotryski, Shu-Wei Yang, William J. Greenlee, Mario Guzzi, Robert A. Hodgson, Kallol Basu, Zheng Tan, Deen Tulshian, Xiaoping Zhang, William T. McElroy, Carina J. Bleickardt, Ginny D. Ho, Deborra Mullins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1335-1339
A series of pyrazoloquinolines, possessing (hetero)arylhydroxymethyl substituents at the quinoline C-4 position were evaluated as PDE10A inhibitors. Among these, methylpyrimidyl analogue 15 was identified as having good rodent and monkey exposure, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfb811a45d35d050707752b9289d337
https://doi.org/10.1016/j.bmcl.2011.12.080
https://doi.org/10.1016/j.bmcl.2011.12.080
Autor:
Mario Guzzi, William J. Greenlee, Xiaoping Zhang, Ginny D. Ho, Shu-Wei Yang, Deen Tulshian, William T. McElroy, Alan Hruza, Jennifer Smotryski, Li Xiao, Tze-Ming Chan, Robert A. Hodgson, Zheng Tan, Diane Rindgen, Deborra Mullins, Carina J. Bleickardt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:235-239
A series of pyrazoloquinoline analogs have been synthesized and shown to bind to PDE10 with high affinity. From the SAR study and our lead optimization efforts, compounds 16 and 27 were found to possess potent oral antipsychotic activity in the MK-80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5db5dabe9226af950d41e122ae77673
https://doi.org/10.1016/j.bmcl.2011.11.023
https://doi.org/10.1016/j.bmcl.2011.11.023
Autor:
R. Bednar, Xiaoping Zhang, Sophie Parmentier-Batteur, Jason M. Uslaner, C. Gambone, G. Xu, Mario Guzzi, Peter H. Hutson, W. Le-Mair, P.E. Sanderson, Robert Mazzola, Nancy A. Sachs, Brian C. Magliaro, Lynn A. Hyde, Deborra Mullins, Michael J. Marino, Antonella Converso, Sean M. Smith, B.K. Eschle, Donnie Eddins, Jeffrey A. Vivian, H. Sloan, Diane Rindgen, E.N. Finger, A. Wang, Zachary A. Turnbull
Publikováno v:
Neuropharmacology. 61:665-676
Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving cognitive dysfunction in Alzheimer’s disease. PF-04447943, (6-[(3 S ,4 S )-4-methyl-1-(pyrimid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa52ce166292113db2ec4badc538492
https://doi.org/10.1016/j.neuropharm.2011.05.009
https://doi.org/10.1016/j.neuropharm.2011.05.009
Autor:
Fabio Pezzoli, Emanuele Grilli, Mario Guzzi, D. Colombo, L Miglio, F. Gramm, R. Gatti, Francesca Bragheri, A. Trita, Vittorio Degiorgio, H. von Känel, M. Döbeli, Elisabeth Müller, Giovanni Isella, Daniel Chrastina, Emiliano Bonera, Ilaria Cristiani
Publikováno v:
Optics Communications. 282:4716-4722
Silicon-rich SiGe alloys represent a promising platform for the development of large-area single-mode optical waveguides to be integrated in silicon-based optical circuits. We find that SiGe layers epitaxially grown on Si successfully guide radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aeb48e77ab429f570bf27825fcc3e29
https://doi.org/10.1016/j.optcom.2009.09.026
https://doi.org/10.1016/j.optcom.2009.09.026
Autor:
Tony Priestley, Vaccaro Henry A, Andrew Stamford, Deborra E Mullins, Michael W. Miller, Tin-Yau Chan, Robert A. Hodgson, Scott Jack D, William J. Greenlee, Liwu Hong, Mario Guzzi, Sarah W. Li, Eric M. Parker, Geoffrey B. Varty, Jay Weinstein, Sue-Ing Lin, Mckittrick Brian A
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6018-6022
Vasopressin 1b (V1b) antagonists have been postulated as possible treatments for depression and anxiety. A novel series of potent and selective V1b antagonists has been identified starting from an in-house screen hit. The incorporation of a sulfonami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1a83509d9b8d8b7220d92453c7462a
https://doi.org/10.1016/j.bmcl.2009.09.050
https://doi.org/10.1016/j.bmcl.2009.09.050
Autor:
E. Wintersberger, Fabio Pezzoli, Emiliano Bonera, J. Stangl, Emanuele Grilli, G. Bauer, Stefano Sanguinetti, Mario Guzzi, H. von Känel, Giovanni Isella, Daniel Chrastina
Publikováno v:
Materials Science in Semiconductor Processing. 11:279-284
A procedure for the quantitative measurement of composition and strain in epitaxial Si 1 - x Ge x / Si heterostructures by means of Raman spectroscopy for any Ge concentration is presented. The calibration of the parameters of this procedure involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45635e4cab4d7d67610ff6e8e9e50a53
https://doi.org/10.1016/j.mssp.2008.09.012
https://doi.org/10.1016/j.mssp.2008.09.012
Autor:
Pond Annamarie, Geoffrey B. Varty, Mario Guzzi, Deborra E Mullins, Guy A. Higgins, Robert A. Hodgson, Donald H. Guthrie, Eric M. Parker, Sherry X. Lu
Publikováno v:
Pharmacology Biochemistry and Behavior. 86:431-440
Vasopressin and corticotropin releasing factor (CRF) are both critical regulators of an animal's stress response and have been linked to anxiety and depression. As such, antagonists of the CRF1 and V1b receptor subtypes are being developed as potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5dd602b3618e8ef24105b25717776a
https://doi.org/10.1016/j.pbb.2006.12.021
https://doi.org/10.1016/j.pbb.2006.12.021
Autor:
Stefano Sanguinetti, Emanuele Poliani, Mario Guzzi, Massimo Gurioli, Emanuele Grilli, Marco Abbarchi, N. Koguchi, M. Bonfanti
Publikováno v:
physica status solidi c. 3:3819-3822
We present a detailed study of the temperature dependence of the single quantum dot emission lineshape in strain free, GaAs/AlGaAs quantum dots. In particular, we analyze the emission lineshape in terms of linewidth, peak energy and sidebands. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f526225895bfe508061e837d6927fc46
https://doi.org/10.1002/pssc.200671542
https://doi.org/10.1002/pssc.200671542