Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Mario G Pavez Giani"'
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Akademický článek
Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells
Autor: Mario G. Pavez-Giani, Lukas Cyganek
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Around one third of patients with mitochondrial disorders develop a kind of cardiomyopathy. In these cases, severity is quite variable ranging from asymptomatic status to severe manifestations including heart failure, arrhythmias, and sudden cardiac
Externí odkaz: https://doaj.org/article/122e0eaeeadd4940965b8e12a44a9f7f
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2
The erythropoietin receptor expressed in skeletal muscle is essential for mitochondrial biogenesis and physiological exercise
Autor: Alexander H. Maass, Kirsten T Nijholt, Willem P. T. Ruifrok, B. Daan Westenbrink, Belend Mahmoud, Herman H W Silljé, Salva R. Yurista, Rudolf A. de Boer, Dirk J. van Veldhuisen, Mario G. Pavez-Giani, Wiek H. van Gilst, L. M. G. Meems, Anouk H G Wolters
Publikováno v: Pflugers Archiv
Pflügers Archiv : European Journal of Physiology. SPRINGER
Erythropoietin (EPO) is a haematopoietic hormone that regulates erythropoiesis, but the EPO-receptor (EpoR) is also expressed in non-haematopoietic tissues. Stimulation of the EpoR in cardiac and skeletal muscle provides protection from various forms
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371e6f2e3e5fb3b86f7a3650108578b2
https://doi.org/10.1007/s00424-021-02577-4
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3
Micronutrient deficiencies in heart failure: mitochondrial dysfunction as a common pathophysiological mechanism?
Autor: Nils Bomer, Mario G. Pavez‐Giani, Niels Grote Beverborg, John G. F. Cleland, Dirk J. Veldhuisen, Peter van der Meer
Heart failure is a devastating clinical syndrome, but current therapies are unable to abolish the disease burden. New strategies to treat or prevent heart failure are urgently needed. Over the past decades, a clear relationship has been established b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878b9f8244c8e30c347ea46602efe62b
https://eprints.gla.ac.uk/263404/1/263404.pdf
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4
Selenoprotein dio2 is a regulator of mitochondrial function, morphology and uprmt in human cardiomyocytes
Autor: Eugene Berezikov, Annet N. Linders, Herman H W Silljé, Peter van der Meer, Warner S. Simonides, Frederik E. Deiman, B. Daan Westenbrink, Mario G. Pavez-Giani, Nils Bomer, Martijn F Hoes, Silke U. Oberdorf-Maass, Christiane L.J. Baierl, Rudolf A. de Boer
Publikováno v: Bomer, N, Pavez-giani, M G, Deiman, F E, Linders, A N, Hoes, M F, Baierl, C L J, Oberdorf-maass, S U, de Boer, R A, Silljé, H H W, Berezikov, E, Simonides, W S, Westenbrink, B D & van der Meer, P 2021, ' Selenoprotein dio2 is a regulator of mitochondrial function, morphology and uprmt in human cardiomyocytes ', International Journal of Molecular Sciences, vol. 22, no. 21, 11906 . https://doi.org/10.3390/ijms222111906
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, 22(21):11906. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 22(21):11906. MDPI AG
International Journal of Molecular Sciences, Vol 22, Iss 11906, p 11906 (2021)
Members of the fetal-gene-program may act as regulatory components to impede deleterious events occurring with cardiac remodeling, and constitute potential novel therapeutic heart failure (HF) targets. Mitochondrial energy derangements occur both dur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f72cfa7c338770407ee75ff06bb0628
https://research.vumc.nl/en/publications/d31b9c3e-7ffb-4dff-895c-e03d9b035c1b
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5
ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ
Autor: Harmen G Booij, Mario G. Pavez-Giani, Salva R. Yurista, B. Daan Westenbrink, Silke U. Oberdorf-Maass, Joan Heller Brown, Nils Bomer, Hendrik Milting, Shigeki Miyamoto, Rudolf A. de Boer, Peter van der Meer, Herman W H Sillje, Paula Giraldo, Pablo I Sánchez-Aguilera, Kirsten T Nijholt
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4427, p 4427 (2021)
International Journal of Molecular Sciences, 22(9), 1-20. MDPI AG
ATPase inhibitory factor-1 (IF1) preserves cellular ATP under conditions of respiratory collapse, yet the function of IF1 under normal respiring conditions is unresolved. We tested the hypothesis that IF1 promotes mitochondrial dysfunction and pathol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddb032f79f13e2d3881ee104d2020c2
http://europepmc.org/articles/PMC8122940
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7
Gain-of-function mutation in ubiquitin ligase KLHL24 causes desmin degradation and dilatation in hiPSC-derived engineered heart tissues
Autor: Herman H W Silljé, Maria C. Bolling, Mario G. Pavez-Giani, Pedro H. Romero-Herrera, Mathilde C.S.C. Vermeer, Adam W. Feinberg, Jacqueline M. Bliley, Peter van der Meer, Maarten P. van den Berg, Duco Kramer, Karla F. Arevalo Gomez, Gilles F. H. Diercks, B. Daan Westenbrink
Publikováno v: JCI The Journal of Clinical Investigation
J Clin Invest
The Journal of Clinical Investigation, 131(17):140615. AMER SOC CLINICAL INVESTIGATION INC
The start codon c.1A>G mutation in KLHL24, encoding ubiquitin ligase KLHL24, results in the loss of 28 N-terminal amino acids (KLHL24-Delta N28) by skipping the initial start codon. In skin, KLHL24-Delta N28 leads to gain of function, excessively tar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a819c703333960b279e2354c3411542f
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8
DIO2 Is a Regulator of Mitochondrial Function, Morphology and UPR mt in Human Cardiomyocytes
Autor: Warner S. Simonides, Frederik E. Deiman, Annet N. Linders, Rudolf A. de Boer, B. Daan Westenbrink, Herman H W Silljé, Mario G. Pavez-Giani, Silke U. Oberdorf-Maass, Martijn F Hoes, Peter van der Meer, Eugene Berezikov, Christiane L.J. Baierl, Nils Bomer
Publikováno v: SSRN Electronic Journal.
Objectives: To elucidate the role of DIO2, member of the fetal-gene-program, in PSC-derived human cardiomyocytes and on mitochondrial dynamics and energetics, specifically. Background: Members of the fetal-gene-program may act as regulatory component
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8219739225e49fffd1302f9bcd5433fc
https://doi.org/10.2139/ssrn.3891284
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9
Sodium-glucose co-transporter 2 inhibition with empagliflozin improves cardiac function in non-diabetic rats with left ventricular dysfunction after myocardial infarction
Autor: Mario G Pavez Giani, Jan-Luuk Hillebrands, Silke U. Oberdorf-Maass, Dirk J. van Veldhuisen, Harry van Goor, Herman H W Silljé, Salva R. Yurista, Rudolf A. de Boer, Elisabeth-Maria Schouten, B. Daan Westenbrink
Publikováno v: European Journal of Heart Failure, 21(7), 862-873. Wiley
AIMS: Sodium-glucose co-transporter 2 (SGLT2) inhibition reduces heart failure hospitalizations in patients with diabetes, irrespective of glycaemic control. We examined the effect of SGLT2 inhibition with empagliflozin (EMPA) on cardiac function in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf8d7c03bf9e36dd5e27ef425701b6b
https://pubmed.ncbi.nlm.nih.gov/31112012
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