Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Mario Ezquerra"'
Autor:
Viviana Torres, Jesica Pérez‐Montesino, Rubén Fernández‐Santiago, Manel Fernández, Ana Camara, Yaroslau Compta, María‐José Martí, Àlex Guerra Beltran, José Rios, Francesc Valldeoriola, Mario Ezquerra
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 8, Pp 2222-2229 (2024)
Abstract Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. In this retrospective study, we analyzed a cohort of Parkinson's disease patients
Externí odkaz:
https://doaj.org/article/bf0de04c7cda432a871f493d306981d5
Autor:
Marta Soto, Manel Fernández, Paloma Bravo, Sara Lahoz, Alicia Garrido, Antonio Sánchez-Rodríguez, María Rivera-Sánchez, María Sierra, Paula Melón, Ana Roig-García, Anna Naito, Bradford Casey, Jordi Camps, Eduardo Tolosa, María-José Martí, Jon Infante, Mario Ezquerra, Rubén Fernández-Santiago
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract The LRRK2 G2019S pathogenic mutation causes LRRK2-associated Parkinson’s disease (L2PD) with incomplete penetrance. LRRK2 non-manifesting carriers (L2NMC) are at PD high risk but predicting pheno-conversion is challenging given the lack of
Externí odkaz:
https://doaj.org/article/fc4ea8c201b04435b88fd67d9335edac
Autor:
Neus Rabaneda-Lombarte, José Manuel Vidal-Taboada, Tony Valente, Mario Ezquerra, Rubén Fernández-Santiago, María José Martí, Yaroslau Compta, Josep Saura, Carme Solà
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Neuroinflammation, in which activated microglia are involved, appears to contribute to the development of Parkinson’s disease (PD). However, the role of microglial activation and the mechanisms governing this process remain uncertain. We f
Externí odkaz:
https://doaj.org/article/7e5408867cbe439e9212674961acdaa6
Autor:
Rubén Fernández-Santiago, Anna Esteve-Codina, Manel Fernández, Francesc Valldeoriola, Almudena Sanchez-Gómez, Esteban Muñoz, Yaroslau Compta, Eduardo Tolosa, Mario Ezquerra, María J. Martí
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract Type-2 diabetes (T2D) and glucose metabolic imbalances have been linked to neurodegenerative diseases, including Parkinson’s disease (PD). To detect potential effects of different glucose levels on gene expression, by RNA-seq we analyzed t
Externí odkaz:
https://doaj.org/article/7246e0b9640e48e58c03a535ba5224ab
Autor:
Estela Pérez-Santamarina, Pedro García-Ruiz, Dolores Martínez-Rubio, Mario Ezquerra, Irene Pla-Navarro, Jorge Puente, María José Martí, Francesc Palau, Janet Hoenicka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Parkinson’s disease (PD) is characterized by cerebral dopamine depletion that causes motor and cognitive deficits. The dopamine-related gene ANKK1 has been associated with neuropsychiatric disorders with a dopaminergic deficiency in the st
Externí odkaz:
https://doaj.org/article/b94e1e211a1843e58d9c48db44c76a82
Autor:
Petar Podlesniy, Margalida Puigròs, Núria Serra, Rubén Fernández-Santiago, Mario Ezquerra, Eduardo Tolosa, Ramon Trullas
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 554-567 (2019)
Background: Both idiopathic and familial Parkinson's disease are associated with mitochondrial dysfunction. Mitochondria have their own mitochondrial DNA (mtDNA) and previous studies have reported that the release of mtDNA is a biomarker of Parkinson
Externí odkaz:
https://doaj.org/article/11e26aeb99bd42769428bedd0a4c838f
Autor:
Estela Pérez‑Santamarina, Pedro García‑Ruiz, Dolores Martínez‑Rubio, Mario Ezquerra, Irene Pla‑Navarro, Jorge Puente, María José Martí, Francesc Palau, Janet Hoenicka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/714fa5d0d0674e93a64ec2eacb44e8b3
Autor:
Diana Luz Juárez-Flores, Ingrid González-Casacuberta, Mario Ezquerra, María Bañó, Francesc Carmona-Pontaque, Marc Catalán-García, Mariona Guitart-Mampel, Juan José Rivero, Ester Tobias, Jose Cesar Milisenda, Eduard Tolosa, Maria Jose Marti, Ruben Fernández-Santiago, Francesc Cardellach, Constanza Morén, Glòria Garrabou
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-13 (2018)
Abstract Background Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models
Externí odkaz:
https://doaj.org/article/3b6607831b0d40529dfd25c7ca31b6a1
Autor:
Diana Luz Juárez-Flores, Mario Ezquerra, ïngrid Gonzàlez-Casacuberta, Aida Ormazabal, Constanza Morén, Eduardo Tolosa, Raquel Fucho, Mariona Guitart-Mampel, Mercedes Casado, Francesc Valldeoriola, Joan de la Torre-Lara, Esteban Muñoz, Ester Tobías, Yaroslau Compta, Francesc Josep García-García, Carmen García-Ruiz, Jose Carlos Fernandez-Checa, Maria José Martí, Josep Maria Grau, Francesc Cardellach, Rafael Artuch, Rubén Fernández-Santiago, Glòria Garrabou
Publikováno v:
Antioxidants, Vol 9, Iss 11, p 1063 (2020)
Idiopathic Parkinson’s disease (iPD) and type 2 diabetes mellitus (T2DM) are chronic, multisystemic, and degenerative diseases associated with aging, with eventual epidemiological co-morbidity and overlap in molecular basis. This study aims to expl
Externí odkaz:
https://doaj.org/article/16b6809826044832a91b3dac74fed192
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Epigenetic mechanisms play a role in human disease but their involvement in pathologies from the central nervous system has been hampered by the complexity of the brain together with its unique cellular architecture and diversity. Until recently, dis
Externí odkaz:
https://doaj.org/article/e8fd0a7838de48a48f857551dd325404