Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Mario D. Aceto"'
Autor:
Ian Derrick, Louis S. Harris, Jillian Helen Broadbear, Stephen M. Husbands, John R. Traynor, James H. Woods, John W. Lewis, Humphrey A. Moynihan, Benjamin M. Greedy, Mark P. Thomas, Mario D. Aceto, Lauren C. Purington
Publikováno v:
Journal of Medicinal Chemistry
We have previously shown that cinnamoyl derivatives of 14β-amino-17-cyclopropylmethyl-7,8-dihydronormorphinone and 7α-aminomethyl-6,14-endoethanonororipavine have pronounced pseudoirreversible μ opioid receptor (MOR) antagonism. The present commun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140c47afdd1873bed06c891e0d2f1aa8
https://doi.org/10.1021/jm301096s
https://doi.org/10.1021/jm301096s
Autor:
Louis S. Harris, Matthew D. Metcalf, Mario D. Aceto, John R. Traynor, James H. Woods, Andrew Coop, Everette L. May
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:869-873
To investigate the effects of carboxylic ester and acid moieties as the N-substituent of opioids, a short series of racemic N-substituted normetazocines was prepared. The introduction of both groups as the normetazocine N-substituent produced compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdefd16d0ea981de32107c1477dfc993
https://doi.org/10.1016/j.bmc.2007.10.030
https://doi.org/10.1016/j.bmc.2007.10.030
Autor:
Anne-Cécile Hiebel,†,‡, Yong Sok Lee, Everette L. May, K. C. Rice, Denise Giuvelis, and Arthur E. Jacobson, Kejun Cheng, Louis S. Harris, Mario D. Aceto, Damon A. Parrish, Andrew Coop, John S. Partilla, Richard B. Rothman, Edward J. Bilsky, Christina M. Dersch, Jeffrey R. Deschamps
Publikováno v:
Journal of Medicinal Chemistry. 50:3765-3776
Both of the enantiomers of 5-(3-hydroxyphenyl)-N-phenylethylmorphan with C9alpha-methyl, C9-methylene, C9-keto, and C9alpha- and C9beta-hydroxy substituents were synthesized and pharmacologically evaluated. Three of the 10 compounds, (1R,5R,9S)-(-)-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2dcaf86f765e76e0a5945531c5ce56
https://doi.org/10.1021/jm061325e
https://doi.org/10.1021/jm061325e
Publikováno v:
European Journal of Pharmacology. 566:88-93
In the search for a selective delta-opioid receptor agonist, (−)-(1 R ,5 R ,9 R )-5,9-dimethyl-2′-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((−)-NIH 11082) and the (+)-enantiomer were synthesized and tested. (−)-NIH 11082 disp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a436f757711149c2c787ea01a88b8a9
https://doi.org/10.1016/j.ejphar.2007.03.008
https://doi.org/10.1016/j.ejphar.2007.03.008
Autor:
Edward J. Bilsky, Kenner C. Rice, Steven A. Adah, Mei-Jing Lee, Christina M. Dersch, Louis S. Harris, In Jong Kim, Arthur E. Jacobson, Andrew Coop, Tyler J. Raymond, Richard B. Rothman, Mario D. Aceto, Everette L. May, Kejun Cheng
Publikováno v:
Organic & Biomolecular Chemistry. 5:1177-1190
Enantiomeric N-phenethyl-m-hydroxyphenylmorphans with various substituents in the ortho, meta or para positions of the aromatic ring in the phenethylamine side-chain (chloro, hydroxy, methoxy, nitro, methyl), as well as a pyridylethyl and a indolylet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce34562cbff65c773331fbccc878ad4e
https://doi.org/10.1039/b618875c
https://doi.org/10.1039/b618875c
Publikováno v:
European Journal of Pharmacology. 524:89-94
JDTic, (3R)-7-hydroxy-N-{(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl}-1,2,3,4-tetrahydro-3-isoquinoline-carboxamide, is a potent and selective κ - opioid antagonist with a very long duration of action [Carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7a62bdb9944269ca586055f6cb8d29
https://doi.org/10.1016/j.ejphar.2005.09.013
https://doi.org/10.1016/j.ejphar.2005.09.013
Autor:
and Andrew Coop, Mario D. Aceto, Elisabeth Greiner, Helmut Schmidhammer, Louis S. Harris, Mariana Spetea
Publikováno v:
Journal of Medicinal Chemistry. 48:5052-5055
In a continued effort to find new substitution patterns in morphinans that would produce strong antinociception while inducing lesser side effects, 4,5-oxygen bridge-opened 6-cyano-substituted N-methylmorphinans (1-3) were synthesized. All compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0273e1d60c09b94c1e9d2ca220a8f6
https://doi.org/10.1021/jm0580205
https://doi.org/10.1021/jm0580205
Autor:
Simon W. Breeden, Claire L. Neilan, James H. Woods, Jillian Helen Broadbear, Mario D. Aceto, Stephen M. Husbands, John W. Lewis, Peter Grundt, John R. Traynor
Publikováno v:
European Journal of Pharmacology. 509:117-125
In the search for opioid agonists with delayed antagonist actions as potential treatments for substance abuse, the bridged morphinan BU74 (17-cyclopropylmethyl-3-hydroxy-[5beta,7beta,3',5']-pyrrolidino-2'[S]-phenyl-7alpha-methyl-6,14-endoetheno morph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92948a04dec738c0b22e34b975818324
https://doi.org/10.1016/j.ejphar.2004.12.035
https://doi.org/10.1016/j.ejphar.2004.12.035
Autor:
Falko Schüllner, Helmut Schmidhammer, Radu C. Moisa, Louis S. Harris, Cynthia Dörfler, Mariana Spetea, and Andrew Coop, Barbara Schraml, Mario D. Aceto, ‡ Ilona P. Berzetei-Gurske
Publikováno v:
Journal of Medicinal Chemistry. 47:3242-3247
The synthesis, biological, and pharmacological evaluation of novel derivatives of cyprodime are described. Their binding affinities at mu, delta, and kappa opioid receptors were evaluated using receptor binding assay. It was observed that the affinit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89faa7f6005acab3fdb80411d97c470e
https://doi.org/10.1021/jm031126k
https://doi.org/10.1021/jm031126k
Autor:
Mario D. Aceto, Irina Beletskaya, Olivia B Lowery, Billy R. Martin, Susan M. Scates, Christopher S. Breivogel
Publikováno v:
European Journal of Pharmacology. 459:139-150
The effects of chronic Delta(9)-tetrahydrocannabinol on cannabinoid receptor levels and receptor-G-protein coupling were investigated. Male Sprague-Dawley rats were infused continuously with low or high dose regimens of Delta(9)-tetrahydrocannabinol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea7dbdfad3f7fac2bcef3851c189a50
https://doi.org/10.1016/s0014-2999(02)02854-6
https://doi.org/10.1016/s0014-2999(02)02854-6