Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mario D'Addario"'
Publikováno v:
Gene. 379:51-61
Cell stressors such as physical forces can activate Sp1-dependent genes but the regulatory mechanisms are not defined. We determined if the stress-induced MAP kinase, p38, can phosphorylate Sp1 and thereby regulate the Sp1 target gene FLNA. We used R
Publikováno v:
Journal of Biological Chemistry. 277:47541-47550
Connective tissue cells in mechanically active environments survive applied physical forces by modifying actin cytoskeletal structures that stabilize cell membranes. In fibroblasts, tensile forces induce the expression of filamin-A, a mechanoprotecti
Autor:
Christopher A. McCulloch, Jennie Fan, Mario D'Addario, Pamela D. Arora, Bernhard Ganss, Richard P. Ellen
Publikováno v:
Journal of Biological Chemistry. 276:31969-31977
Cells in mechanically active environments can activate cytoprotective mechanisms to maintain membrane integrity in the face of potentially lethal applied forces. Cytoprotection may be mediated by expression of membrane-associated cytoskeletal protein
Autor:
Emanuela Vaccher, Jingwu Xu, Ali Ahmad, Mario D'Addario, José Menezes, Riccardo Dolcetti, Laurent Knafo, U. Prasad, James F. Jones
Publikováno v:
The Journal of Immunology. 164:2815-2822
Anti-latent membrane protein-1 (LMP-1) is an EBV-encoded type III integral membrane protein with oncogenic potential that is expressed most consistently in various EBV-associated malignancies. Unlike many other EBV proteins, LMP-1 Abs have rarely bee
Autor:
Mario D'Addario, Jean Gosselin, R C Gallo, D V Ablashi, Louis Flamand, J Hiscott, José Menezes
Publikováno v:
Journal of Virology. 65:5105-5110
The human herpesvirus 6 (HHV-6) is known to interact intimately with cells of the immune system. Here we report that HHV-6 is a potent inducer of interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) in cultures of peripheral blo
Autor:
Louis Flamand, Daniel Oth, Gilles Lamoureux, Mario D'Addario, Jean Gosselin, José Menezes, John Hiscott
Publikováno v:
European Journal of Immunology. 21:203-208
Tumor necrosis factor-α (TNF-α), which is produced mainly by monocyte/macrophage cells, has diverse physiological functions on lymphoid cells. Moreover, it has been shown that TNF-α exhibits antiviral activities. Here we report that Epstein-Barr v
Publikováno v:
The Journal of biological chemistry. 278(52)
Mechanical loading of connective tissues induces the expression of extracellular matrix and cytoskeletal genes that are involved in matrix remodeling. These processes depend in part on force transmission through beta1 integrins and actin filaments, b
Autor:
Tiina Kainulainen, Christopher A. McCulloch, Mario D'Addario, Yuanyi Feng, Alexandra Pender, Predrag Lekic
Publikováno v:
The Journal of biological chemistry. 277(24)
Cells in mechanically challenged environments must cope with high amplitude forces to maintain cell viability and tissue homeostasis. Currently, force-induced cell death and the identity of mechanoprotective factors are not defined. We examined death
Publikováno v:
Journal of molecular biology. 308(3)
Epstein-Barr virus (EBV) is a ubiquitous and highly immunotropic gamma herpesvirus that infects more than 90 % of humans worldwide. Its pathogenicity leads to a number of diseases including tumors that result from EBV's ability to readily transform B
Publikováno v:
Journal of molecular biology. 298(5)
Epstein-Barr virus (EBV) is a human herpesvirus that interacts with various immunocompetent cells that carry the EBV receptor (CD21/CR2). EBV binds to CR2 through its major envelope glycoprotein 350 (gp350). Previously we had demonstrated that EBV an