Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mario Cocco"'
Publikováno v:
Life Science Alliance
As human B-cells differentiate, IRF4 switches occupancy and acquires CTCF colocalisation and IRF4 regulatory output diverts from cell activation to plasma cell state genes in conjunction with XBP1, whereas BLIMP1 represses activation.
The activa
The activa
The activated B-cell (ABC) to plasmablast transition is the cusp of antibody secreting cell (ASC) differentiation but is incompletely defined. We apply expression time-courses, parsimonious gene correlation network analysis, and ChIP-seq to explore t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09976896e895078c9afbfd81d27aec2
Autor:
Nicole L McDermott, Amel Saadi, Mario Cocco, Matthew Care, Ruth de Tute, Roger Owen, Gina Doody, Reuben Tooze
Publikováno v:
The Journal of Immunology. 204:153.17-153.17
Cellular adhesion plays an important role in determining homing and retention of cells to specific locations. Antibody-secreting plasma cells (PCs) depend on access to niche microenvironments for survival, but the factors that control the adhesion be
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
The unfolded protein response (UPR) and activation of XBP1 is necessary for high secretory efficiency and functional differentiation of antibody secreting cells (ASCs). The UPR additionally includes a branch in which membrane-bound transcription fact
Autor:
Ming Wang, David R. Westhead, Matthew A. Care, Jon Laye, Gina M. Doody, Ming Du, Reuben Tooze, Andrew Jack, S. Barrans, Mario Cocco, Nicholas A. Barnes, Yuanxue Huang
Publikováno v:
Nucleic Acids Research
Interferon regulatory factor 4 (IRF4) is central to the transcriptional network of activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL), an aggressive lymphoma subgroup defined by gene expression profiling. Since cofactor association modif
Autor:
Matthew A. Care, Andy C. Rawstron, Gina M. Doody, Reuben Tooze, Sophie Stephenson, Adam Davison, Mario Cocco, David R. Westhead, Darren J. Newton, Nicholas A. Barnes
Publikováno v:
The Journal of Immunology. 189:5773-5785
Plasma cells (PCs), the terminal effectors of humoral immunity, are short-lived unless supported by niche environments in which they may persist for years. No model system has linked B cell activation with niche function to allow the in vitro generat
Publikováno v:
The Journal of Immunology. 189:253-260
During cellular differentiation, mRNA transcription and translation require precise coordination. The mechanisms controlling this are not well defined. IL-21 is an important regulator of plasma cell differentiation, and it controls the master regulat
Autor:
P van Cleef, Anna Onnis, Cristiana Bellan, Lorenzo Leoncini, Joshua Nyagol, Bessie Byakika, Mario Cocco, Piero Tosi, Stefano Lazzi, G De Falco, Eleonora Leucci, H. van Krieken, A.F. van Rijk
Publikováno v:
Journal of Pathology, 216, 440-50
Journal of Pathology, 216, 4, pp. 440-50
Journal of Pathology, 216, 4, pp. 440-50
Contains fulltext : 69103.pdf (Publisher’s version ) (Closed access) The molecular feature of Burkitt lymphoma (BL) is the translocation that places c-Myc under the control of immunoglobulin gene regulatory elements. However, there is accumulating
Autor:
David Y. Mason, Margaret Jones, Mette Christiansen, Jacques J.M. van Dongen, Stephen Hamilton Dutoit, Tim Svenstrup Poulsen, Maryse Baia, Christiane Copie Bergman, Steen Hauge Matthiesen, Evi Pouliou, José Cabeçadas, Dimitra Anagnostou, Juan F. García, Mateus Crespo, Anja Mottok, J. Han van Krieken, Anke van Rijk, Juan C. Cigudosa, Lorenzo Leoncini, Martin-Leo Hansmann, Mario Cocco
Publikováno v:
Journal of Hematopathology, 1, 119-126. Springer-Verlag
Aarhus University
Journal of Hematopathology
van Rijk, A, Mason, D, Jones, M, Cabeçadas, J, Crespo, M, Cigudosa, JC, Garcia, JF, Leoncini, L, Cocco, M, Hansmann, ML, Mottok, A, Bergman, CC, Gaulard, P, Anagnostou, D, Pouliou, E, Hamilton-Dutoit, S J, Christiansen, MH, Poulsen, TS, Matthiesen, SH, van Dongen, J & van Krieken, JH 2008, ' Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approach. ', Journal of Hematopathology (Online), vol. 1, pp. 119-26 .
Aarhus University
Journal of Hematopathology
van Rijk, A, Mason, D, Jones, M, Cabeçadas, J, Crespo, M, Cigudosa, JC, Garcia, JF, Leoncini, L, Cocco, M, Hansmann, ML, Mottok, A, Bergman, CC, Gaulard, P, Anagnostou, D, Pouliou, E, Hamilton-Dutoit, S J, Christiansen, MH, Poulsen, TS, Matthiesen, SH, van Dongen, J & van Krieken, JH 2008, ' Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approach. ', Journal of Hematopathology (Online), vol. 1, pp. 119-26 .
Lymphomas originating from the lymphatic system comprise about 30 entities classified according to the World Health Organization (WHO). The histopathological diagnosis is generally considered difficult and prone to mistakes. Since non-random chromoso
Autor:
Eleonora Leucci, Joshua Nyagol, Stefano Lazzi, Rocco Cantisani, Antonicelli Giuseppina, Giovanna Cerino, Martin Owang, Cristiana Bellan, Karin Schürfeld, Lorenzo Leoncini, Valentina Costanzo, Giulia De Falco, Anna Onnis, Walter Mwanda, Susanna Mannucci, Robert Iriso, Mario Cocco, Francesco Imperatore
Endemic, sporadic and HIV-associated Burkitt lymphoma (BL) all have a B-cell phenotype and a MYC translocation, but a variable association with the Epstein-Barr virus (EBV). However, there is still no satisfactory explanation of how EBV participates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e73bad829c4411cfef3446698c5508
http://hdl.handle.net/11365/1009248
http://hdl.handle.net/11365/1009248