Extract from the Marine Seaweed Padina pavonica Protects Mitochondrial Biomembranes from Damage by Amyloidogenic Peptides

Autor: Mario Caruana, Angelique Camilleri, Maria Ylenia Farrugia, Stephanie Ghio, Michaela Jakubíčková, Ruben J. Cauchi, Neville Vassallo

Publikováno v: Molecules, Vol 26, Iss 5, p 1444 (2021)

The identification of compounds which protect the double-membrane of mitochondrial organelles from disruption by toxic confomers of amyloid proteins may offer a therapeutic strategy to combat human neurodegenerative diseases. Here, we exploited an ex

Externí odkaz: https://doaj.org/article/2c5a4fb5ff9b4b7b932d8ad13f24f47b

EP.WE.859Pain management in critical limb ischaemia patients: a clinical audit

Autor: Mohamed Elahwal, Anja Imsirovic, Genevive Almond, Mario Caruana, Rahul Bagga

Publikováno v: British Journal of Surgery. 108

Aims Critical Limb Ischaemia (CLI) patients often present with ischaemic rest pain and uncontrolled pain can impact on quality of life. To improve pain control, a set a of trust-wide guidelines were developed to standardise pain management for CLI pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efa270275b54802ad2c80f8f68311e70
https://doi.org/10.1093/bjs/znab308.103

Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin

Autor: Frits Kamp, Stephanie Ghio, Felix Schmidt, Angelique Camilleri, Mario Caruana, Ruben J. Cauchi, Neville Vassallo, Andrei Leonov, Christian Griesinger, Daniel Weckbecker, Sergey Ryazanov, Armin Giese

Publikováno v: Biochimica et biophysica acta. Biomembranes. 1862(2)

Misfolding and aggregate formation by the tau protein has been closely related with neurotoxicity in a large group of human neurodegenerative disorders, which includes Alzheimer's disease. Here, we investigate the membrane-active properties of tau ol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1d3096e3aa4e2b640ddecfe34839ec
https://pubmed.ncbi.nlm.nih.gov/31521630

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

Autor: Roland Benz, Martin Fuhrman, Hope Y Agbemenyah, Joon Lee, Lalit Kaurani, Gregor Eichele, Markus Zweckstetter, Gaurav Jain, Nasrollah Rezaei-Ghaleh, Andre Fischer, Alan L. Gillman, Gayane Grigorian, Ratnesh Lal, Sergey Ryazanov, Mario Caruana, Armin Giese, Christian Griesinger, Martin Korte, Eva Benito, Angelique Camilleri, Andrei Leonov, Neville Vassallo, Jens Wagner, Fernando Teran Arce, Hendrik Urbanke, Ana Martinez Hernandez, Anja Schneider, Petra Wilken

Publikováno v: EMBO Molecular Medicine
EMBO molecular medicine 10(1), 32-47 (2018). doi:10.15252/emmm.201707825
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 32-47 (2018)
EMBO molecular medicine
EMBO molecular medicine, vol 10, iss 1

Alzheimer’s disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136f4a325e014173319325e91132fab8

Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro

Autor: Tobias Högen, Neville Vassallo, Frits Kamp, Charles Scerri, Johanna Neuner, Mario Caruana, Armin Giese, Felix Schmidt

Publikováno v: Biochimica et biophysica acta. 1818(11)

Cumulative evidence now suggests that the abnormal aggregation of the protein α-synuclein (αS) is a critical factor in triggering neurodegeneration in Parkinson's disease (PD). In particular, a fundamental pathogenetic mechanism appears to involve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310e0b3e71596e5f865b8100bec6f57a
https://pubmed.ncbi.nlm.nih.gov/22634381